Results 31 to 40 of about 165,191 (338)

Magnesium-containing bioceramics stimulate exosomal miR-196a-5p secretion to promote senescent osteogenesis through targeting Hoxa7/MAPK signaling axis

Bioactive Materials, 2023
Stem cell senescence is characterized by progressive functional dysfunction and secretory phenotypic changes including decreased proliferation, dysfunction of osteogenic and angiogenic differentiation, increased secretion of the senescence-associated ...
Lei Qi, Xin Fang, Jinge Yan, Cancan Pan, Wei-Wen Ge, Jing Wang, Steve GF. Shen, Kai-Li Lin, Lei Zhang   +8 more
semanticscholar   +1 more source

Formation and Developmental Specification of the Odontogenic and Osteogenic Mesenchymes

Frontiers in Cell and Developmental Biology, 2020
Within the mandible, the odontogenic and osteogenic mesenchymes develop in a close proximity and form at about the same time. They both originate from the cranial neural crest. These two condensing ecto-mesenchymes are soon separated from each other by a
Eva Svandova, Renata Peterkova, Eva Matalova, Eva Matalova, Herve Lesot   +4 more
doaj   +1 more source

Bone mesenchymal stem cells stimulation by magnetic nanoparticles and a static magnetic field: release of exosomal miR-1260a improves osteogenesis and angiogenesis

Journal of Nanobiotechnology, 2021
Background The therapeutic potential of exosomes derived from stem cells has attracted increasing interest recently, because they can exert similar paracrine functions of stem cells and overcome the limitations of stem cells transplantation.
Di Wu, Xiao-Ting Chang, Jingjing Tian, Lin Kang, Yuanhao Wu, Jie-Ying Liu, Xiangdong Wu, Yue Huang, Bo Gao, Hai Wang, G. Qiu, Zhi-Hong Wu   +11 more
semanticscholar   +1 more source

ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta [PDF]

, 2008
Osteogenesis imperfecta is an inherited disorder characterized by increased bone fragility, fractures, and osteoporosis, and most cases are caused by mutations affecting the type I collagen genes.
Ralston, Stuart H., Thomas S Lisse, Eckhard Wolf, Quintanilla-Martinez Leticia, de Angelis Martin Hrabé, Fuchs Helmut, Lisse Thomas S, Gabriele Hoelzlwimmer, Hrabě de Angelis, M., Martin Hrabé de Angelis, Hölzlwimmer, G., Abe, Koichiro, Rathkolb, Birgit, de Angelis, Martin Hrabe, Hans, Wolfgang, Rathkolb, B., Quintanilla-Martinez, Leticia, Ralston, Stuart H, Koichiro Abe, Abe, K., Wolf Eckhard, Przemeck, G.K.H., Hans Wolfgang, Hoelzlwimmer, Gabriele, Przemeck Gerhard K. H, Fuchs, H., Abe Koichiro, Hoelzlwimmer Gabriele, Hrabé de Angelis, Martin, Wolf, E., Miep Helfrich, Lisse, Thomas S, Quintanilla-Martinez, L., Thiele, F., Ralston, S.H., Helmut Fuchs, Gerhard K H Przemeck, Helfrich, M., Helfrich, Miep, Przemeck, Gerhard K. H., Lisse, Thomas S., Thiele, Frank, Frank Thiele, Helfrich Miep, Stuart H Ralston, Wolfgang Hans, Hans, W., Przemeck, Gerhard K H, Thiele Frank, Rathkolb Birgit, Ralston Stuart H, Lisse, T.S., Birgit Rathkolb, Fuchs, Helmut, Wolf, Eckhard, Leticia Quintanilla-Martinez, Lisse, T.S. ; Thiele, F. ; Fuchs, H. ; Hans, W. ; Przemeck, G.K.H. ; Abe, K. ; Rathkolb, B. ; Quintanilla-Martinez, L. ; Hölzlwimmer, G. ; Helfrich, M. ; Wolf, E. ; Ralston, S.H. ; Hrabé de Angelis, M.   +56 more
core   +2 more sources

Orchestration of energy metabolism and osteogenesis by Mg2+ facilitates low-dose BMP-2-driven regeneration

Bioactive Materials, 2022
The clinical application of bone morphogenetic protein-2 (BMP-2) is limited by several factors, including ineffectiveness at low doses and severe adverse effects at high doses.
Si-Han Lin, S. Yin, Junfeng Shi, Guang-Zheng Yang, Xutao Wen, Wen-Jie Zhang, Ming-Liang Zhou, Xin-Quan Jiang   +7 more
semanticscholar   +1 more source

Mechanotransduction in osteogenesis

Bone & Joint Research, 2020
Bone is one of the most highly adaptive tissues in the body, possessing the capability to alter its morphology and function in response to stimuli in its surrounding environment. The ability of bone to sense and convert external mechanical stimuli into a biochemical response, which ultimately alters the phenotype and function of the cell, is described ...
Stewart, S, Darwood, A, Masouros, S, Higgins, C, Ramasamy, A   +4 more
openaire   +3 more sources

Regulation and Role of Transcription Factors in Osteogenesis

International Journal of Molecular Sciences, 2021
Bone is a dynamic tissue constantly responding to environmental changes such as nutritional and mechanical stress. Bone homeostasis in adult life is maintained through bone remodeling, a controlled and balanced process between bone-resorbing osteoclasts ...
W. C. Chan, Z. Tan, Michael K T To, D. Chan   +3 more
semanticscholar   +1 more source

Studies in Osteogenesis [PDF]

Acta Orthopaedica Scandinavica, 1950
(1950). Studies in Osteogenesis. Acta Orthopaedica Scandinavica: Vol. 19, No. 4, pp. 419-432.
H, WILLESTAEDT, G, LEVANDER, L, HULT
openaire   +2 more sources

Microfluidic device for enhancement and analysis of osteoblast differentiation in three-dimensional cell cultures

Journal of Biological Engineering, 2023
Three-dimensional (3D) cell cultures are to date the gold standard in biomedical research fields due to their enhanced biological functions compared to conventional two-dimensional (2D) cultures. 3D cell spheroids, as well as organoids, are better suited
Michael Killinger, Adéla Kratochvilová, Eva Ingeborg Reihs, Eva Matalová, Karel Klepárník, Mario Rothbauer   +5 more
doaj   +1 more source

Osteogenesis imperfecta [PDF]

The Lancet, 2016
Osteogenesis imperfecta is a phenotypically and molecularly heterogeneous group of inherited connective tissue disorders that share similar skeletal abnormalities causing bone fragility and deformity. Previously, the disorder was thought to be an autosomal dominant bone dysplasia caused by defects in type I collagen, but in the past 10 years ...
FORLINO, ANTONELLA, Marini, Joan C.
openaire   +3 more sources