Results 41 to 50 of about 165,191 (338)
International Journal on Biological Sciences, 2022 Irisin is well-known to contribute to bone homeostasis due to its bidirectional regulation on osteogenesis and osteoclastogenesis. However, the mechanisms of irisin involved in mesenchymal stem/stromal cells (MSCs)-derived osteogenesis are still under ...
Yuan Xue +9 more
semanticscholar +1 more source
Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
Nature, 2014 The mammalian skeletal system harbours a hierarchical system of mesenchymal stem cells, osteoprogenitors and osteoblasts sustaining lifelong bone formation.
Anjali P. Kusumbe +2 more
semanticscholar +1 more source
Cell Transplantation, 2021 Dental pulp stem cells (DPSCs) are one promising cell source of mesenchymal stem cells in bone tissue engineering. However, it remains unknown that the molecules and signaling pathways involved in osteogenesis of DPSCs. Hence, this study investigated the
Xinqi Huang +6 more
doaj +1 more source
Stem cell research & therapeutics, 2020 As important players in cell-to-cell communication, exosomes (exo) are believed to play a similar role in promoting fracture healing. This study investigated whether exosomes derived from bone marrow mesenchymal stem cells (BMMSC-Exos) could improve ...
Lu Zhang +9 more
semanticscholar +1 more source
Frontiers in Endocrinology, 2022 Previous studies have revealed that melatonin could play a role in anti-osteoporosis and promoting osteogenesis. However, the effects of melatonin treatment on osteoporotic bone defect and the mechanism underlying the effects of melatonin on angiogenesis
Sheng Zheng +6 more
semanticscholar +1 more source
Materials Today Bio, 2022 Recently, strategies that focus on biofunctionalized implant surfaces to enhance bone defect healing through the synergistic regulation of osteogenesis, angiogenesis, and osteoclastogenesis have attracted increasing attention in the bone tissue ...
Min-Hao Wu +8 more
semanticscholar +1 more source
Theranostics, 2021 Rationale: Emerging evidence indicates that the growth of blood vessels and osteogenesis is tightly coordinated during bone development. However, the molecular regulators of intercellular communication in the bone microenvironment are not well studied ...
Jyotirmaya Behera +3 more
semanticscholar +1 more source
Cell communication and relevant signaling pathways in osteogenesis–angiogenesis coupling
Bone ResearchOsteogenesis is the process of bone formation mediated by the osteoblasts, participating in various bone-related physiological processes including bone development, bone homeostasis and fracture healing. It exhibits temporal and spatial interconnectivity
Shuqing Li +6 more
semanticscholar +1 more source
The Human Gut Microbiota: A Key Mediator of Osteoporosis and Osteogenesis
International Journal of Molecular Sciences, 2021 An expanding body of research asserts that the gut microbiota has a role in bone metabolism and the pathogenesis of osteoporosis. This review considers the human gut microbiota composition and its role in osteoclastogenesis and the bone healing process ...
K. Seely +4 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2021 Osteogenesis imperfecta is a genetic disorder disrupting bone development and remodeling. The primary causes of osteogenesis imperfecta are pathogenic variants of collagen and collagen processing genes.
Christopher L. Schwebach +2 more
doaj +1 more source