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Osteoporosis, or steroid-induced osteonecrosis of the hip, is accompanied by increased bone marrow adipogenesis. Such a disorder of adipogenic/osteogenic differentiation, affecting bone-marrow-derived mesenchymal stem cells (BMSCs), contributes to bone ...
Chenglong Wang +7 more
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Osteogenic differentiation is the basis of bone growth and repair related to many diseases, in which evaluating the degree and ability of osteogenic transformation is quite important and highly desirable.
Zhenyu Zheng +8 more
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Während meiner Diplomarbeit habe ich ein Protokoll für die Isolierung und Expansion von MSCs aus der Wharton-Sulze etabliert. Die daraus isolierten Zellen wurden anhand der Kriterien der International Society for Cellular Therapy charakterisiert. Hierfür wurde die Expression von mesenchymalen Antigenen mittels Durchflusszytometrie bestimmt und die ...
Martin Fröhlich
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Human mesenchymal stem cells (hMSCs) are widely used to model osteogenic differentiation in vitro, yet few studies compare the numerous available protocols.
M Eischen-Loges +8 more
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Similarity-based metric analysis approach for predicting osteogenic differentiation correlation coefficients and discovering the novel osteogenic-related gene FOXA1 in BMSCs [PDF]
Background As a powerful tool, bioinformatics analysis is playing an increasingly important role in many fields. Osteogenic differentiation is a complex biological process involving the fine regulation of numerous genes and signaling pathways.
Lingtong Sun +3 more
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Patterned Piezoelectric Scaffolds for Osteogenic Differentiation [PDF]
The morphological clues of scaffolds can determine cell behavior and, therefore, the patterning of electroactive polymers can be a suitable strategy for bone tissue engineering. In this way, this work reports on the influence of poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) electroactive micropatterned scaffolds on the proliferation and ...
Teresa Marques-Almeida +4 more
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Icariin promotes osteogenic differentiation by upregulating alpha-enolase expression
Osteogenic differentiation is a crucial biological process for maintaining bone remodelling. Aerobic glycolysis is the main source of energy for osteogenic differentiation.
Dingbang Xie +8 more
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Plant extracts are widely used as traditional medicines. Sophora flavescens Aiton-derived natural compounds exert various beneficial effects, such as anti-inflammatory, anticancer, antioxidant, and antiregenerative activities, through their bioactive compounds, including flavonoids and alkaloids.
Hyung-Mun Yun +5 more
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The Regulatory Landscape of Osteogenic Differentiation [PDF]
AbstractDifferentiation of osteoblasts from mesenchymal stem cells (MSCs) is an integral part of bone development and homeostasis, and may when improperly regulated cause disease such as bone cancer or osteoporosis. Using unbiased high-throughput methods we here characterize the landscape of global changes in gene expression, histone modifications, and
Anne-Mari, Håkelien +8 more
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Osteogenic Differentiation in Healthy and Pathological Conditions [PDF]
This review focuses on the osteogenic differentiation of mesenchymal stem cells (MSC), bone formation and turn-over in good and ill skeletal fates. The interacting molecular pathways which control bone remodeling in physiological conditions during a lifelong process are described.
VALENTI, Maria Teresa +2 more
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