Results 1 to 10 of about 139,682 (311)

Icariin promotes osteogenic differentiation by upregulating alpha-enolase expression

Biochemistry and Biophysics Reports, 2023
Osteogenic differentiation is a crucial biological process for maintaining bone remodelling. Aerobic glycolysis is the main source of energy for osteogenic differentiation.
Dingbang Xie, Yunteng Xu, Wanping Cai, Junkuan Zhuo, Zaishi Zhu, Haifeng Zhang, Yimin Zhang, Xin Lan, Hui Yan   +8 more
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circ-Iqsec1 induces bone marrow-derived mesenchymal stem cell (BMSC) osteogenic differentiation through the miR-187-3p/Satb2 signaling pathway

Arthritis Research & Therapy, 2022
Background Bone marrow-derived mesenchymal stem cells (BMSCs) are general progenitor cells of osteoblasts and adipocytes and they are characterized as a fundamental mediator for bone formation.
Lixia Fan, Kaiyun Yang, Ruixuan Yu, Houde Hui, Wenliang Wu   +4 more
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Lysophosphatidic acid induces proliferation and osteogenic differentiation of human dental pulp stem cell through lysophosphatidic acid receptor 3/extracellular signal-regulated kinase signaling axis

Journal of Dental Sciences, 2023
Background/purpose: Human dental pulp stem cells (hDPSCs) possess excellent proliferative and osteogenic differentiation potentials. This study aimed to elucidate the role of lysophosphatidic acid (LPA) signaling in the proliferation and osteogenic ...
Soon Chul Heo, Bo Ram Keum, Eun Jin Seo, Jinhwan Yoon, Sanghwa Jeong, Gabor J. Tigyi, Derek Norman, Il Ho Jang, Hyung Joon Kim   +8 more
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Involvement of the long noncoding RNA H19 in osteogenic differentiation and bone regeneration

Stem Cell Research & Therapy, 2021
Osteogenic differentiation and bone regeneration are complex processes involving multiple genes and multiple steps. In this review, we summarize the effects of the long noncoding RNA (lncRNA) H19 on osteogenic differentiation.
Zimo Zhou, Mohammad Showkat Hossain, Da Liu   +2 more
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Mechanical Sensing Element PDLIM5 Promotes Osteogenesis of Human Fibroblasts by Affecting the Activity of Microfilaments

Biomolecules, 2021
Human skin fibroblasts (HSFs) approximate the multidirectional differentiation potential of mesenchymal stem cells, so they are often used in differentiation, cell cultures, and injury repair. They are an important seed source in the field of bone tissue
Xiaolan Huang, Rongmei Qu, Yan Peng, Yuchao Yang, Tingyu Fan, Bing Sun, Asmat Ullah Khan, Shutong Wu, Kuanhai Wei, Chujiang Xu, Jingxing Dai, Jun Ouyang, Shizhen Zhong   +12 more
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Probing Notch1-Dll4 signaling in regulating osteogenic differentiation of human mesenchymal stem cells using single cell nanobiosensor

Scientific Reports, 2022
Human mesenchymal stem cells (hMSCs) have great potential in cell-based therapies for tissue engineering and regenerative medicine due to their self-renewal and multipotent properties.
Yuwen Zhao, Rui Yang, Zoe Bousraou, Kiarra Richardson, Shue Wang   +4 more
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miR-637 Inhibits Osteogenic Differentiation of Human Intervertebral Disc Cartilage Endplate Stem Cells by Targeting WNT5A

Journal of Investigative Surgery, 2022
Background: Degenerative disk disease (DDD) remains the leading incentive of severe lumbago. DDD is mainly caused by degeneration of cartilage endplate (CEP).
Yunsheng Chen, Qin Chen, Mingliang Zhong, Canhua Xu, Yaohong Wu, Rongchun Chen   +5 more
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MicroRNA treatment modulates osteogenic differentiation potential of mesenchymal stem cells derived from human chorion and placenta

Scientific Reports, 2021
Mesenchymal stem cells (MSCs) are important in regenerative medicine because of their potential for multi-differentiation. Bone marrow, chorion and placenta have all been suggested as potential sources for clinical application.
Kulisara Marupanthorn, Chairat Tantrawatpan, Pakpoom Kheolamai, Duangrat Tantikanlayaporn, Sirikul Manochantr   +4 more
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Mesenchymal stem cell-derived exosomes have altered microRNA profiles and induce osteogenic differentiation depending on the stage of differentiation. [PDF]

PLoS ONE, 2018
Human mesenchymal stem cell (hMSC)-derived exosomes have shown regenerative effects, but their role in osteogenesis and the underlying mechanism are yet to be determined.
Xiaoqin Wang, Omar Omar, Forugh Vazirisani, Peter Thomsen, Karin Ekström   +4 more
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RUNX3 derived hsa_circ_0005752 accelerates the osteogenic differentiation of adipose-derived stem cells via the miR-496/MDM2-p53 pathway

Regenerative Therapy, 2021
Background: Circular RNAs (circRNAs) are non-coding RNAs that play a pivotal role in bone diseases. RUNX3 was an essential transcriptional regulator during osteogenesis.
Ming Wang, Yifan Huan, Xiyang Li, Jing Li, Guohua Lv   +4 more
doaj   +1 more source