Results 31 to 40 of about 85,126 (267)
Frontiers in Molecular Biosciences, 2022 Background: The available therapeutic options of bone defects, fracture nonunion, and osteoporosis remain limited, which are closely related to the osteogenic differentiation of bone marrow–derived mesenchymal stem cells (BMSCs).
Lingtong Sun +8 more
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AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs [PDF]
Bone Research, 2017 AbstractAFF1 and AFF4 belong to the AFF (AF4/FMR2) family of proteins, which function as scaffolding proteins linking two different transcription elongation factors, positive elongation factor b (P-TEFb) and ELL1/2, in super elongation complexes (SECs). Both AFF1 and AFF4 regulate gene transcription through elongation and chromatin remodeling. However,
Zhou, Chen-chen +9 more
openaire +2 more sources
Stem Cell Research & Therapy, 2022 Background Circular RNAs (circRNAs) are a new type of stable noncoding RNA and have been proven to play a crucial role in osteoporosis. This study explored the role and mechanism of hsa_circ_0001485 in osteogenic differentiation.
Shan-Chuang Chen +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Long noncoding RNA (lncRNA) is a noncoding RNA with a length of more than 200 bases. It plays an important role in the occurrence and development of diseases. Research on lncRNAs has received increasing attention.
Haitao Wang +4 more
doaj +1 more source
Proliferation and Osteogenic Differentiation of hMSCs on Biomineralized Collagen [PDF]
Frontiers in Bioengineering and Biotechnology, 2020 Biomineralized collagen with intrafibrillar calcium phosphate mineral provides an excellent mimic of the composition and structure of the extracellular matrix of bone, from nano- to micro-scale. Scaffolds prepared from this material have the potential to become the next-generation of synthetic bone graft substitutes, as their unique properties make ...
Pereira, Daniel de Melo +3 more
openaire +4 more sources
Cellular Physiology and Biochemistry, 2014 Background/Aims: The aim of this study was to analyze the effect of BMP2 on osteogenic differentiation of human adipose tissue-derived stromal cells (hADSCs).
Sun Young Lee +5 more
doaj +1 more source
Frontiers in Endocrinology, 2021 The osteogenic differentiation capacity of senescent bone marrow mesenchymal stem cells (MSCs) is reduced. p53 not only regulates cellular senescence but also functions as a negative regulator in bone formation.
Chao Xia +5 more
doaj +1 more source
Vitamin D and Osteogenic Differentiation in the Artery Wall [PDF]
Clinical Journal of the American Society of Nephrology, 2008 Vascular calcification is widespread, particularly in patients with chronic kidney disease, who receive, among other treatments, active vitamin D supplements. Emerging evidence indicates that vascular calcification is a regulated process that resembles embryonic endochondral osteogenesis, involving osteoblastic differentiation of vascular smooth muscle
Jeffrey J, Hsu +2 more
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Stem Cell Research & Therapy, 2020 Background Osteogenic differentiation of bone mesenchymal stem cells (BMSCs) is regulated by numerous signaling pathways. Dopamine (DA), a neurotransmitter, has previously been demonstrated to induce new bone formation by stimulating the receptors on ...
Chen-Xi Wang +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source