Results 31 to 40 of about 91,170 (312)

Histone modifications centric-regulation in osteogenic differentiation [PDF]

Cell Death Discovery, 2021
AbstractHistone modification critically contributes to the epigenetic control of gene expression by changing the configuration of chromatin and modifying the access of transcription factors to gene promoters. Recently, we observed that histone acetylation and crotonylation mediated the expression of endocytosis-related genes and tumor-related immune ...
Kun Li, Jinxiang Han, Ziqiang Wang
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Induction of Osteogenic Differentiation by Hedgehog Proteins

Biochemical and Biophysical Research Communications, 1997
In this study we asked whether members of the hedgehog gene family are involved in osteogenesis. C3H10T1/2 cells and MC3T3-E1 cells expressed the putative hedgehog receptor patched (Ptc) gene. Medium conditioned by chicken embryo fibroblast cultures expressing either Indian hedgehog or Sonic hedgehog stimulated alkaline phosphatase (APase) activity in ...
T, Nakamura, T, Aikawa, M, Iwamoto-Enomoto, M, Iwamoto, Y, Higuchi, M, Pacifici, N, Kinto, A, Yamaguchi, S, Noji, K, Kurisu, T, Matsuya, P, Maurizio   +11 more
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Oral fibroblasts rescue osteogenic differentiation of mesenchymal stem cells after exposure to Zoledronic acid in a paracrine effect

Frontiers in Pharmacology, 2023
Background: Medication-related osteonecrosis of the jaw is a serious complication that develops in oncologic patients treated with Zoledronic acid. Although used for over 30 years, the influence of Zoledronic acid on bone has been thoroughly investigated,
Tal Berg, Tal Berg, Ofri Doppelt-Flikshtain, Ofri Doppelt-Flikshtain, Benjamin R. Coyac, Benjamin R. Coyac, Hadar Zigdon-Giladi, Hadar Zigdon-Giladi, Hadar Zigdon-Giladi   +8 more
doaj   +1 more source

Proliferation and Osteogenic Differentiation of hMSCs on Biomineralized Collagen [PDF]

Frontiers in Bioengineering and Biotechnology, 2020
Biomineralized collagen with intrafibrillar calcium phosphate mineral provides an excellent mimic of the composition and structure of the extracellular matrix of bone, from nano- to micro-scale. Scaffolds prepared from this material have the potential to become the next-generation of synthetic bone graft substitutes, as their unique properties make ...
Pereira, Daniel de Melo, Eischen-Loges, Maria, Birgani, Zeinab Tahmasebi, Habibovic, Pamela   +3 more
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Bioinformatics-Guided Analysis Uncovers AOX1 as an Osteogenic Differentiation-Relevant Gene of Human Mesenchymal Stem Cells

Frontiers in Molecular Biosciences, 2022
Background: The available therapeutic options of bone defects, fracture nonunion, and osteoporosis remain limited, which are closely related to the osteogenic differentiation of bone marrow–derived mesenchymal stem cells (BMSCs).
Lingtong Sun, Jianfei Ma, Juan Chen, Zhijun Pan, Zhijun Pan, Zhijun Pan, Lijun Li, Lijun Li, Lijun Li   +8 more
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Osteogenic Differentiation of Dental Follicle Stem Cells [PDF]

International Journal of Medical Sciences, 2012
Stem cells are defined as clonogenic cells capable of self-renewal and multi-lineage differentiation. A population of these cells has been identified in human Dental Follicle (DF). Dental Follicle Stem Cells (DFSCs) were found in pediatric unerupted wisdom teeth and have been shown to differentiate, under particular conditions, into various cell types ...
Mori G, Ballini A, Carbone C, Oranger A, Di Benedetto A, Rapone B, Cantore S, BRUNETTI, GIACOMINA, DI COMITE, Mariasevera, COLUCCI, Silvia Concetta, GRANO, Maria, GRASSI, Felice Roberto   +11 more
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Hsa_circ_0001485 promoted osteogenic differentiation by targeting BMPR2 to activate the TGFβ-BMP pathway

Stem Cell Research & Therapy, 2022
Background Circular RNAs (circRNAs) are a new type of stable noncoding RNA and have been proven to play a crucial role in osteoporosis. This study explored the role and mechanism of hsa_circ_0001485 in osteogenic differentiation.
Shan-Chuang Chen, Tao Jiang, Qi-Yu Liu, Zi-Tao Liu, Yu-Fei Su, Hai-Tao Su   +5 more
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LncRNA TCONS_00023297 Regulates the Balance of Osteogenic and Adipogenic Differentiation in Bone Marrow Mesenchymal Stem Cells and the Coupling Process of Osteogenesis and Angiogenesis

Frontiers in Cell and Developmental Biology, 2021
Long noncoding RNA (lncRNA) is a noncoding RNA with a length of more than 200 bases. It plays an important role in the occurrence and development of diseases. Research on lncRNAs has received increasing attention.
Haitao Wang, Peng Wei, Yi Zhang, Yuebai Li, Li Yin   +4 more
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AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs [PDF]

Bone Research, 2017
AbstractAFF1 and AFF4 belong to the AFF (AF4/FMR2) family of proteins, which function as scaffolding proteins linking two different transcription elongation factors, positive elongation factor b (P-TEFb) and ELL1/2, in super elongation complexes (SECs). Both AFF1 and AFF4 regulate gene transcription through elongation and chromatin remodeling. However,
Zhou, Chen-chen, Xiong, Qiu-chan, Zhu, Xin-xing, Du, Wen, Deng, Peng, Li, Xiao-bing, Jiang, Yi-zhou, Zou, Shu-juan, Wang, Cun-yu, Yuan, Quan   +9 more
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The p53/miR-145a Axis Promotes Cellular Senescence and Inhibits Osteogenic Differentiation by Targeting Cbfb in Mesenchymal Stem Cells

Frontiers in Endocrinology, 2021
The osteogenic differentiation capacity of senescent bone marrow mesenchymal stem cells (MSCs) is reduced. p53 not only regulates cellular senescence but also functions as a negative regulator in bone formation.
Chao Xia, Tianyuan Jiang, Yonghui Wang, Xiaoting Chen, Yan Hu, Yanhong Gao   +5 more
doaj   +1 more source