Results 31 to 40 of about 7,514 (117)

Bioinformatics-Guided Analysis Uncovers AOX1 as an Osteogenic Differentiation-Relevant Gene of Human Mesenchymal Stem Cells

Frontiers in Molecular Biosciences, 2022
Background: The available therapeutic options of bone defects, fracture nonunion, and osteoporosis remain limited, which are closely related to the osteogenic differentiation of bone marrow–derived mesenchymal stem cells (BMSCs).
Lingtong Sun, Jianfei Ma, Juan Chen, Zhijun Pan, Zhijun Pan, Zhijun Pan, Lijun Li, Lijun Li, Lijun Li   +8 more
doaj   +1 more source

AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs [PDF]

Bone Research, 2017
AbstractAFF1 and AFF4 belong to the AFF (AF4/FMR2) family of proteins, which function as scaffolding proteins linking two different transcription elongation factors, positive elongation factor b (P-TEFb) and ELL1/2, in super elongation complexes (SECs). Both AFF1 and AFF4 regulate gene transcription through elongation and chromatin remodeling. However,
Zhou, Chen-chen, Xiong, Qiu-chan, Zhu, Xin-xing, Du, Wen, Deng, Peng, Li, Xiao-bing, Jiang, Yi-zhou, Zou, Shu-juan, Wang, Cun-yu, Yuan, Quan   +9 more
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Histone modifications centric-regulation in osteogenic differentiation [PDF]

Cell Death Discovery, 2021
AbstractHistone modification critically contributes to the epigenetic control of gene expression by changing the configuration of chromatin and modifying the access of transcription factors to gene promoters. Recently, we observed that histone acetylation and crotonylation mediated the expression of endocytosis-related genes and tumor-related immune ...
Kun Li, Jinxiang Han, Ziqiang Wang
openaire   +3 more sources

LncRNA TCONS_00023297 Regulates the Balance of Osteogenic and Adipogenic Differentiation in Bone Marrow Mesenchymal Stem Cells and the Coupling Process of Osteogenesis and Angiogenesis

Frontiers in Cell and Developmental Biology, 2021
Long noncoding RNA (lncRNA) is a noncoding RNA with a length of more than 200 bases. It plays an important role in the occurrence and development of diseases. Research on lncRNAs has received increasing attention.
Haitao Wang, Peng Wei, Yi Zhang, Yuebai Li, Li Yin   +4 more
doaj   +1 more source

Hsa_circ_0001485 promoted osteogenic differentiation by targeting BMPR2 to activate the TGFβ-BMP pathway

Stem Cell Research & Therapy, 2022
Background Circular RNAs (circRNAs) are a new type of stable noncoding RNA and have been proven to play a crucial role in osteoporosis. This study explored the role and mechanism of hsa_circ_0001485 in osteogenic differentiation.
Shan-Chuang Chen, Tao Jiang, Qi-Yu Liu, Zi-Tao Liu, Yu-Fei Su, Hai-Tao Su   +5 more
doaj   +1 more source

The p53/miR-145a Axis Promotes Cellular Senescence and Inhibits Osteogenic Differentiation by Targeting Cbfb in Mesenchymal Stem Cells

Frontiers in Endocrinology, 2021
The osteogenic differentiation capacity of senescent bone marrow mesenchymal stem cells (MSCs) is reduced. p53 not only regulates cellular senescence but also functions as a negative regulator in bone formation.
Chao Xia, Tianyuan Jiang, Yonghui Wang, Xiaoting Chen, Yan Hu, Yanhong Gao   +5 more
doaj   +1 more source

BMP2 Increases Adipogenic Differentiation in the Presence of Dexamethasone, which is Inhibited by the Treatment of TNF-α in Human Adipose Tissue-Derived Stromal Cells

Cellular Physiology and Biochemistry, 2014
Background/Aims: The aim of this study was to analyze the effect of BMP2 on osteogenic differentiation of human adipose tissue-derived stromal cells (hADSCs).
Sun Young Lee, Jung Hee Lee, Jee young Kim, Yong Chan Bae, Kuen Tak Suh, Jin Sup Jung   +5 more
doaj   +1 more source

Dopamine D1 receptor-mediated activation of the ERK signaling pathway is involved in the osteogenic differentiation of bone mesenchymal stem cells

Stem Cell Research & Therapy, 2020
Background Osteogenic differentiation of bone mesenchymal stem cells (BMSCs) is regulated by numerous signaling pathways. Dopamine (DA), a neurotransmitter, has previously been demonstrated to induce new bone formation by stimulating the receptors on ...
Chen-Xi Wang, Xi-Yuan Ge, Ming-Yue Wang, Ting Ma, Yu Zhang, Ye Lin   +5 more
doaj   +1 more source

Improvement of osteogenic differentiation in umbilical cord-derived human mesenchymal stem cells through specific MiRNA inhibition

Scientific Reports
Umbilical cord-derived human mesenchymal stem cells (UC-hMSCs) are multipotent stem cells with great potential for treating bone diseases. Although they can be easily isolated from umbilical cord tissue, their osteogenic differentiation is less efficient
Ladda Meesuk, Pakpoom Kheolamai, Chairat Tantrawatpan, Jintamai Suwanprateeb, Sirikul Manochantr   +4 more
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KLF9 Promotes Osteogenic Differentiation of Dental Stem Cells by Negatively Regulating Notch1 Mediated Signaling Pathway

Frontiers in Bioscience-Landmark, 2023
Background: Human dental stem cells (DSCs) are excellent sources of cells for treating dental and craniofacial diseases. However, the mechanisms regulating DSC osteogenic differentiation are still unclear. In this study, we aimed to determine the role of
Xinyuan Zhao, Zizhao Mai, Ye Lu, Li Cui, Jinhua Yu   +4 more
doaj   +1 more source