Ginsenoside Re Promotes Osteoblast Differentiation in Mouse Osteoblast Precursor MC3T3-E1 Cells and a Zebrafish Model [PDF]
Molecules, 2016 Bone homeostasis is tightly regulated to balance bone formation and bone resorption. Many anabolic drugs are used as bone-targeted therapeutic agents for the promotion of osteoblast-mediated bone formation or inhibition of osteoclast-mediated bone ...
Hye-Min Kim +9 more
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Spatially resolved osteoblast-traced transcriptomics uncovers TGF-β as a combination target with sclerostin in osteoporosis [PDF]
Bone ResearchDynamic transitions of mature osteoblasts between active and quiescent states are essential for bone homeostasis and present a promising target for osteoanabolic therapy.
Ahyoun Choi +16 more
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miR-452-3p inhibited osteoblast differentiation by targeting Smad4 [PDF]
PeerJ, 2021 Osteoblast differentiation is a complex process that is essential for normal bone formation. A growing number of studies have shown that microRNAs (miRNAs) are key regulators in a variety of physiological and pathological processes, including ...
Ming Wu +6 more
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SLC38A2 provides proline and alanine to regulate postnatal bone mass accrual in mice
Frontiers in Physiology, 2022 Amino acids have recently emerged as important regulators of osteoblast differentiation and bone formation. Osteoblasts require a continuous supply of amino acids to sustain biomass production to fuel cell proliferation, osteoblast differentiation and ...
Leyao Shen +4 more
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Constitutive activation of Gli2 impairs bone formation in postnatal growing mice. [PDF]
PLoS ONE, 2013 Indian hedgehog (Ihh) signaling is indispensable for osteoblast differentiation during endochondral bone development in the mouse embryo.
Kyu Sang Joeng, Fanxin Long
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Microorganisms, 2021 Osteoblast differentiation is important for the development of bone and the maintenance of bone density. Propionibacterium freudenreichii is a probiotic with an anti-inflammatory property.
Jiah Yeom, Seongho Ma, Young-Hee Lim
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BMP-2 Induced Expression of Alx3 That Is a Positive Regulator of Osteoblast Differentiation. [PDF]
PLoS ONE, 2013 Bone morphogenetic proteins (BMPs) regulate many aspects of skeletal development, including osteoblast and chondrocyte differentiation, cartilage and bone formation, and cranial and limb development.
Takashi Matsumoto +10 more
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Core-binding factor beta is required for osteoblast differentiation during fibula fracture healing
Journal of Orthopaedic Surgery and Research, 2021 Background Growing evidence has implicated core-binding factor beta (Cbfb) as a contributor to osteoblast differentiation, which plays a key role in fracture healing. Herein, we aimed to assess whether Cbfb affects osteoblast differentiation after fibula
Tuanmao Guo +6 more
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Osteoblast biology: developmental origin and interactive nature of osteoblasts
, 2021 Bone formation occurs throughout life to support growth and bone remodeling in response to mechanical forces, metabolic needs, and tissue repair upon injury. The physiological requirement for continuous bone renewal to accommodate remodeling necessitates recruitment, proliferation, and differentiation of bone-forming osteoblasts to counteract the ...
van der Eerden, Bram C.J. +1 more
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Transcriptional program of osteoblast differentiation : coordinated activation of Notch, Wnt, and TGF-[beta] signaling pathways in MC3T3 cell line [PDF]
, 2005 In order to examine the early events in osteoblast differentiation, three different model systems for osteoblast differentiation were compared: mouse pre-osteoblastic cell line MC3T3; mouse myoblastic cell line C2C12 and primary mouse calvarial ...
Zamurovic, Natasa
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