MACF1 Mediates the Impairment of Mechanical Unloading on Osteoblast Differentiation via F-Actin/ERK/Runx2 Axis [PDF]
CellsDecreased osteoblast differentiation contributes to bone loss induced by mechanical unloading. However, the underlying mechanism is still unclear. We previously found that microtubule actin crosslinking factor 1 (MACF1), a key cytoskeletal protein, plays
Lifang Hu +7 more
doaj +2 more sources
Molecules, 2016 Bone homeostasis is tightly regulated to balance bone formation and bone resorption. Many anabolic drugs are used as bone-targeted therapeutic agents for the promotion of osteoblast-mediated bone formation or inhibition of osteoclast-mediated bone ...
Hye-Min Kim +9 more
doaj +3 more sources
Pannexin 3-mediated adenosine triphosphate release from pre-osteoblasts promotes osteoblast differentiation through P2X4 receptor activation [PDF]
Frontiers in PhysiologyIncreased pre-osteoblast cell density within bone resorption areas is a key factor in promoting osteoblast differentiation; however, the molecular mechanisms underlying this process remain poorly understood. In this study, we investigated the role of ATP
Hiroaki Kito +5 more
doaj +2 more sources
Limitations of bone formation in oral implantology: inhibition of osteoblast functions by gingival tissues [PDF]
, 2010 PhDClinical observation suggest that bone formation is influenced by the environmental niche where it takes place and specifically that soft connective tissues may inhibit the bone healing process.
Al-Masri, Maher
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Transcriptional program of osteoblast differentiation : coordinated activation of Notch, Wnt, and TGF-[beta] signaling pathways in MC3T3 cell line [PDF]
, 2005 In order to examine the early events in osteoblast differentiation, three different model systems for osteoblast differentiation were compared: mouse pre-osteoblastic cell line MC3T3; mouse myoblastic cell line C2C12 and primary mouse calvarial ...
Zamurovic, Natasa
core +1 more source
Frontiers in Pharmacology, 2022 Osteoblast dysfunction, induced by high glucose (HG), negatively impacts bone homeostasis and contributes to the pathology of diabetic osteoporosis (DOP).
Yue Xuan +14 more
doaj +1 more source
The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice [PDF]
, 2010 Nearly every extracellular ligand that has been found to play a role in regulating bone biology acts, at least in part, through MAPK pathways. Nevertheless, much remains to be learned about the contribution of MAPKs to osteoblast biology in vivo. Here we
Zhai, Bo +33 more
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Repression of osteoblast maturation by ERRα accounts for bone loss induced by estrogen deficiency. [PDF]
PLoS ONE, 2013 ERRα is an orphan member of the nuclear receptor family, the complete inactivation of which confers resistance to bone loss induced by ageing and estrogen withdrawal to female mice in correlation with increased bone formation in vivo.
Marlène Gallet +14 more
doaj +1 more source
Biology Open, 2019 Impaired osteoblast differentiation may result in bone metabolic diseases such as osteoporosis. It was reported recently that hedgehog (Hh) signaling and autophagy are two important regulators of bone differentiation.
Zhanying Hu, Bo Chen, Qiong Zhao
doaj +1 more source
Primary human osteoblast cultures
, 2011 Osteoblast cultures can be used to investigate the mechanisms of bone formation, to probe the cellular and molecular basis of bone disease, and to screen for potential therapeutic agents that affect bone formation.
Dillon, Jane P. +6 more
core +5 more sources