MACF1 Mediates the Impairment of Mechanical Unloading on Osteoblast Differentiation via F-Actin/ERK/Runx2 Axis [PDF]
CellsDecreased osteoblast differentiation contributes to bone loss induced by mechanical unloading. However, the underlying mechanism is still unclear. We previously found that microtubule actin crosslinking factor 1 (MACF1), a key cytoskeletal protein, plays
Lifang Hu +7 more
doaj +2 more sources
Dual Inhibition of GSK3 and JAK by BIO Suppresses Osteoblast Differentiation and Mineralization of Human Mesenchymal Cells [PDF]
Current Issues in Molecular BiologyGlycogen synthase kinase-3 (GSK3) inhibition is a commonly used approach to promote osteogenic differentiation through activation of Wnt signaling. However, 6-bromoindirubin-3′-oxime (BIO), which is commonly used for GSK3 inhibition, also targets JAK ...
Nihal Almuraikhi +3 more
doaj +2 more sources
Priming of mouse pre-osteoblasts with Interleukin-3 attenuates TNF-α-induced-inhibition of osteoblast differentiation [PDF]
BMC Musculoskeletal DisordersBackground In inflammatory bone loss disorders, such as rheumatoid arthritis and post-menopausal osteoporosis, TNF-α is an important effector cytokine that promotes osteoclastogenesis and inhibits osteoblastogenesis.
Vikrant Piprode +4 more
doaj +2 more sources
miR-452-3p inhibited osteoblast differentiation by targeting Smad4 [PDF]
PeerJ, 2021 Osteoblast differentiation is a complex process that is essential for normal bone formation. A growing number of studies have shown that microRNAs (miRNAs) are key regulators in a variety of physiological and pathological processes, including ...
Ming Wu +6 more
doaj +2 more sources
Frontiers in Endocrinology, 2021 Neural cell adhesion molecule (NCAM) is involved in cell multi-directional differentiation, but its role in osteoblast differentiation is still poorly understood.
Bin-Feng Cheng +10 more
doaj +1 more source
BMP-2 Induced Expression of Alx3 That Is a Positive Regulator of Osteoblast Differentiation. [PDF]
PLoS ONE, 2013 Bone morphogenetic proteins (BMPs) regulate many aspects of skeletal development, including osteoblast and chondrocyte differentiation, cartilage and bone formation, and cranial and limb development.
Takashi Matsumoto +10 more
doaj +1 more source
Microorganisms, 2021 Osteoblast differentiation is important for the development of bone and the maintenance of bone density. Propionibacterium freudenreichii is a probiotic with an anti-inflammatory property.
Jiah Yeom, Seongho Ma, Young-Hee Lim
doaj +1 more source
Constitutive activation of Gli2 impairs bone formation in postnatal growing mice. [PDF]
PLoS ONE, 2013 Indian hedgehog (Ihh) signaling is indispensable for osteoblast differentiation during endochondral bone development in the mouse embryo.
Kyu Sang Joeng, Fanxin Long
doaj +1 more source
Core-binding factor beta is required for osteoblast differentiation during fibula fracture healing
Journal of Orthopaedic Surgery and Research, 2021 Background Growing evidence has implicated core-binding factor beta (Cbfb) as a contributor to osteoblast differentiation, which plays a key role in fracture healing. Herein, we aimed to assess whether Cbfb affects osteoblast differentiation after fibula
Tuanmao Guo +6 more
doaj +1 more source
MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass
eLife, 2022 MAF1, a key repressor of RNA polymerase (pol) III-mediated transcription, has been shown to promote mesoderm formation in vitro. Here, we show that MAF1 plays a critical role in regulating osteoblast differentiation and bone mass. Global deletion of MAF1
Ellen Phillips +10 more
doaj +1 more source