Results 1 to 10 of about 71,796 (264)

Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation.

PLoS Genetics, 2010
Excessive accumulation of bone marrow adipocytes observed in senile osteoporosis or age-related osteopenia is caused by the unbalanced differentiation of MSCs into bone marrow adipocytes or osteoblasts. Several transcription factors are known to regulate
Yoshimi Tokuzawa, Ken Yagi, Yzumi Yamashita, Yutaka Nakachi, Itoshi Nikaido, Hidemasa Bono, Yuichi Ninomiya, Yukiko Kanesaki-Yatsuka, Masumi Akita, Hiromi Motegi, Shigeharu Wakana, Tetsuo Noda, Fred Sablitzky, Shigeki Arai, Riki Kurokawa, Toru Fukuda, Takenobu Katagiri, Christian Schönbach, Tatsuo Suda, Yosuke Mizuno, Yasushi Okazaki   +20 more
doaj   +2 more sources

Dual Inhibition of GSK3 and JAK by BIO Suppresses Osteoblast Differentiation and Mineralization of Human Mesenchymal Cells [PDF]

Current Issues in Molecular Biology
Glycogen synthase kinase-3 (GSK3) inhibition is a commonly used approach to promote osteogenic differentiation through activation of Wnt signaling. However, 6-bromoindirubin-3′-oxime (BIO), which is commonly used for GSK3 inhibition, also targets JAK ...
Nihal Almuraikhi, Latifa Alkhamees, Sumaiya Tareen, Manikandan Muthurangan   +3 more
doaj   +2 more sources

Priming of mouse pre-osteoblasts with Interleukin-3 attenuates TNF-α-induced-inhibition of osteoblast differentiation [PDF]

BMC Musculoskeletal Disorders
Background In inflammatory bone loss disorders, such as rheumatoid arthritis and post-menopausal osteoporosis, TNF-α is an important effector cytokine that promotes osteoclastogenesis and inhibits osteoblastogenesis.
Vikrant Piprode, Shubhanath Behera, Juilee Karhade, Suhas T. Mhaske, Mohan R. Wani   +4 more
doaj   +2 more sources

SP7 inhibits osteoblast differentiation at a late stage in mice. [PDF]

PLoS ONE, 2012
RUNX2 and SP7 are essential transcription factors for osteoblast differentiation at an early stage. Although RUNX2 inhibits osteoblast differentiation at a late stage, the function of SP7 at the late stage of osteoblast differentiation is not fully ...
Carolina A Yoshida, Hisato Komori, Zenjiro Maruyama, Toshihiro Miyazaki, Keishi Kawasaki, Tatsuya Furuichi, Ryo Fukuyama, Masako Mori, Kei Yamana, Kouhei Nakamura, Wenguang Liu, Satoru Toyosawa, Takeshi Moriishi, Hiroshi Kawaguchi, Kenji Takada, Toshihisa Komori   +15 more
doaj   +3 more sources

miR-452-3p inhibited osteoblast differentiation by targeting Smad4 [PDF]

PeerJ, 2021
Osteoblast differentiation is a complex process that is essential for normal bone formation. A growing number of studies have shown that microRNAs (miRNAs) are key regulators in a variety of physiological and pathological processes, including ...
Ming Wu, Hongyan Wang, Dece Kong, Jin Shao, Chao Song, Tieyi Yang, Yan Zhang   +6 more
doaj   +2 more sources

Neural Cell Adhesion Molecule Regulates Osteoblastic Differentiation Through Wnt/β-Catenin and PI3K-Akt Signaling Pathways in MC3T3-E1 Cells

Frontiers in Endocrinology, 2021
Neural cell adhesion molecule (NCAM) is involved in cell multi-directional differentiation, but its role in osteoblast differentiation is still poorly understood.
Bin-Feng Cheng, Xiao Feng, Yao-Xin Gao, Shao-Qin Jian, Shi-Rao Liu, Mian Wang, Yun-Fei Xie, Lei Wang, Zhi-Wei Feng, Hai-Jie Yang, Hai-Jie Yang   +10 more
doaj   +1 more source

Osteoblast Differentiation at a Glance [PDF]

Medical Science Monitor Basic Research, 2016
Ossification is a tightly regulated process, performed by specialized cells called osteoblasts. Dysregulation of this process may cause inadequate or excessive mineralization of bones or ectopic calcification, all of which have grave consequences for human health.
Rutkovskiy, Arkady, Stensløkken, Kåre-Olav, Vaage, Ingvar Jarle   +2 more
openaire   +2 more sources

BMP-2 Induced Expression of Alx3 That Is a Positive Regulator of Osteoblast Differentiation. [PDF]

PLoS ONE, 2013
Bone morphogenetic proteins (BMPs) regulate many aspects of skeletal development, including osteoblast and chondrocyte differentiation, cartilage and bone formation, and cranial and limb development.
Takashi Matsumoto, Atsushi Yamada, Ryo Aizawa, Dai Suzuki, Masayuki Tsukasaki, Wataru Suzuki, Mutsuko Nakayama, Koutaro Maki, Matsuo Yamamoto, Kazuyoshi Baba, Ryutaro Kamijo   +10 more
doaj   +1 more source

Probiotic Propionibacterium freudenreichii MJ2 Enhances Osteoblast Differentiation and Mineralization by Increasing the OPG/RANKL Ratio

Microorganisms, 2021
Osteoblast differentiation is important for the development of bone and the maintenance of bone density. Propionibacterium freudenreichii is a probiotic with an anti-inflammatory property.
Jiah Yeom, Seongho Ma, Young-Hee Lim
doaj   +1 more source

Constitutive activation of Gli2 impairs bone formation in postnatal growing mice. [PDF]

PLoS ONE, 2013
Indian hedgehog (Ihh) signaling is indispensable for osteoblast differentiation during endochondral bone development in the mouse embryo.
Kyu Sang Joeng, Fanxin Long
doaj   +1 more source