Results 11 to 20 of about 71,796 (264)

Core-binding factor beta is required for osteoblast differentiation during fibula fracture healing

Journal of Orthopaedic Surgery and Research, 2021
Background Growing evidence has implicated core-binding factor beta (Cbfb) as a contributor to osteoblast differentiation, which plays a key role in fracture healing. Herein, we aimed to assess whether Cbfb affects osteoblast differentiation after fibula
Tuanmao Guo, Yanli Xing, Zhongning Chen, Xianhong Wang, Haiyun Zhu, Lan Yang, Yong Yan   +6 more
doaj   +1 more source

MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass

eLife, 2022
MAF1, a key repressor of RNA polymerase (pol) III-mediated transcription, has been shown to promote mesoderm formation in vitro. Here, we show that MAF1 plays a critical role in regulating osteoblast differentiation and bone mass. Global deletion of MAF1
Ellen Phillips, Naseer Ahmad, Li Sun, James Iben, Christopher J Walkey, Aleksandra Rusin, Tony Yuen, Clifford J Rosen, Ian M Willis, Mone Zaidi, Deborah L Johnson   +10 more
doaj   +1 more source

The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation

Frontiers in Cell and Developmental Biology, 2021
Receptor activator of NF-κB ligand (RANKL)-binding peptides inhibit bone resorption and were recently shown to activate bone formation. The stimulatory mechanism underlying bone formation associated with these peptides was explained as RANKL-reverse ...
Fatma Rashed, Fatma Rashed, Shingo Kamijyo, Yuri Shimizu, Yuna Hirohashi, Masud Khan, Yasutaka Sugamori, Ramachandran Murali, Kazuhiro Aoki   +8 more
doaj   +1 more source

Differential Iron Requirements for Osteoblast and Adipocyte Differentiation

JBMR Plus, 2021
ABSTRACT Bone marrow mesenchymal progenitor cells are precursors for various cell types including osteoblasts, adipocytes, and chondrocytes. The external environment and signals act to direct the pathway of differentiation. Importantly, situations such as aging and chronic kidney disease display alterations in the
Daniel F. Edwards, Christopher J. Miller, Arelis Quintana‐Martinez, Christian S. Wright, Matthew Prideaux, Gerald J. Atkins, William R. Thompson, Erica L. Clinkenbeard   +7 more
openaire   +4 more sources

Regulation of osteoblast differentiation mediated by BMP, Notch, and CCN3/NOV

Japanese Dental Science Review, 2008
Osteoblasts originate from common progenitors, which are capable of differentiating into other mesenchymal cell lineages such as chondrocytes, myoblasts and adipocytes.
Akira Yamaguchi, Kei Sakamoto, Tokutarou Minamizato, Kenichi Katsube, Shoichi Nakanishi   +4 more
doaj   +1 more source

Protein palmitoylation regulates osteoblast differentiation through BMP-induced osterix expression. [PDF]

PLoS ONE, 2009
Osteoporosis is one of the most common diseases and can be treated by either anti-resorption drugs, anabolic drugs, or both. To search for anabolic drug targets for osteoporosis therapy, it is crucial to understand the biology of bone forming cells ...
Wai Fook Leong, Tielin Zhou, Gek Liang Lim, Baojie Li   +3 more
doaj   +1 more source

SLC38A2 provides proline and alanine to regulate postnatal bone mass accrual in mice

Frontiers in Physiology, 2022
Amino acids have recently emerged as important regulators of osteoblast differentiation and bone formation. Osteoblasts require a continuous supply of amino acids to sustain biomass production to fuel cell proliferation, osteoblast differentiation and ...
Leyao Shen, Yilin Yu, Courtney M. Karner, Courtney M. Karner, Courtney M. Karner   +4 more
doaj   +1 more source

E3 Ubiquitin Ligase-Mediated Regulation of Osteoblast Differentiation and Bone Formation

Frontiers in Cell and Developmental Biology, 2021
The ubiquitin–proteasome system (UPS) is an essential pathway that regulates the homeostasis and function of intracellular proteins and is a crucial protein-degradation system in osteoblast differentiation and bone formation.
Jianlin Shen, Jianlin Shen, Bowen Fu, Yanfang Li, Yanjiao Wu, Hongxun Sang, Heshi Zhang, Haibin Lin, Huan Liu, Wenhua Huang, Wenhua Huang, Wenhua Huang   +11 more
doaj   +1 more source

p38 MAPK Signaling in Osteoblast Differentiation [PDF]

Frontiers in Cell and Developmental Biology, 2016
The skeleton is a highly dynamic tissue whose structure relies on the balance between bone deposition and resorption. This equilibrium, which depends on osteoblast and osteoclast functions, is controlled by multiple factors that can be modulated post-translationally.
Rodríguez Carballo, Edgardo, Gamez Molina, Beatriz, Ventura Pujol, Francesc   +2 more
openaire   +5 more sources

Hedgehog signaling regulates osteoblast differentiation in zebrafish larvae through modulation of autophagy

Biology Open, 2019
Impaired osteoblast differentiation may result in bone metabolic diseases such as osteoporosis. It was reported recently that hedgehog (Hh) signaling and autophagy are two important regulators of bone differentiation.
Zhanying Hu, Bo Chen, Qiong Zhao
doaj   +1 more source