Results 11 to 20 of about 892,989 (253)
Protein palmitoylation regulates osteoblast differentiation through BMP-induced osterix expression. [PDF]
PLoS ONE, 2009 Osteoporosis is one of the most common diseases and can be treated by either anti-resorption drugs, anabolic drugs, or both. To search for anabolic drug targets for osteoporosis therapy, it is crucial to understand the biology of bone forming cells ...
Wai Fook Leong +3 more
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Molecules, 2016 Bone homeostasis is tightly regulated to balance bone formation and bone resorption. Many anabolic drugs are used as bone-targeted therapeutic agents for the promotion of osteoblast-mediated bone formation or inhibition of osteoclast-mediated bone ...
Hye-Min Kim +9 more
doaj +3 more sources
Limitations of bone formation in oral implantology: inhibition of osteoblast functions by gingival tissues [PDF]
, 2010 PhDClinical observation suggest that bone formation is influenced by the environmental niche where it takes place and specifically that soft connective tissues may inhibit the bone healing process.
Al-Masri, Maher
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Frontiers in Cell and Developmental Biology, 2021 Receptor activator of NF-κB ligand (RANKL)-binding peptides inhibit bone resorption and were recently shown to activate bone formation. The stimulatory mechanism underlying bone formation associated with these peptides was explained as RANKL-reverse ...
Fatma Rashed +8 more
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Regulation of osteoblast differentiation mediated by BMP, Notch, and CCN3/NOV
Japanese Dental Science Review, 2008 Osteoblasts originate from common progenitors, which are capable of differentiating into other mesenchymal cell lineages such as chondrocytes, myoblasts and adipocytes.
Akira Yamaguchi +4 more
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Transcriptional program of osteoblast differentiation : coordinated activation of Notch, Wnt, and TGF-[beta] signaling pathways in MC3T3 cell line [PDF]
, 2005 In order to examine the early events in osteoblast differentiation, three different model systems for osteoblast differentiation were compared: mouse pre-osteoblastic cell line MC3T3; mouse myoblastic cell line C2C12 and primary mouse calvarial ...
Zamurovic, Natasa
core +1 more source
SLC38A2 provides proline and alanine to regulate postnatal bone mass accrual in mice
Frontiers in Physiology, 2022 Amino acids have recently emerged as important regulators of osteoblast differentiation and bone formation. Osteoblasts require a continuous supply of amino acids to sustain biomass production to fuel cell proliferation, osteoblast differentiation and ...
Leyao Shen +4 more
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E3 Ubiquitin Ligase-Mediated Regulation of Osteoblast Differentiation and Bone Formation
Frontiers in Cell and Developmental Biology, 2021 The ubiquitin–proteasome system (UPS) is an essential pathway that regulates the homeostasis and function of intracellular proteins and is a crucial protein-degradation system in osteoblast differentiation and bone formation.
Jianlin Shen +11 more
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Biology Open, 2019 Impaired osteoblast differentiation may result in bone metabolic diseases such as osteoporosis. It was reported recently that hedgehog (Hh) signaling and autophagy are two important regulators of bone differentiation.
Zhanying Hu, Bo Chen, Qiong Zhao
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BMC Musculoskeletal Disorders, 2020 Background The differentiation of human stromal (mesenchymal) stem cells (hMSCs) is a critical procedure for the development of osteoblast. SNHG14 is a newly discovered lncRNA that has been barely studied.
Mingchang Du +5 more
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