Results 11 to 20 of about 122,840 (307)
Osteoblast Differentiation at a Glance [PDF]
Medical Science Monitor Basic Research, 2016 Ossification is a tightly regulated process, performed by specialized cells called osteoblasts. Dysregulation of this process may cause inadequate or excessive mineralization of bones or ectopic calcification, all of which have grave consequences for human health.
Rutkovskiy, Arkady +2 more
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Frontiers in Cell and Developmental Biology, 2021 Receptor activator of NF-κB ligand (RANKL)-binding peptides inhibit bone resorption and were recently shown to activate bone formation. The stimulatory mechanism underlying bone formation associated with these peptides was explained as RANKL-reverse ...
Fatma Rashed +8 more
doaj +1 more source
Fibronectin regulates calvarial osteoblast differentiation [PDF]
Journal of Cell Science, 1996 ABSTRACT The secretion of fibronectin by differentiating osteoblasts and its accumulation at sites of osteogenesis suggest that fibronectin participates in bone formation. To test this directly, we determined whether fibronectin-cell interactions regulate progressive differentiation of cultured fetal rat calvarial osteoblasts.
A M, Moursi +6 more
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Regulation of osteoblast differentiation mediated by BMP, Notch, and CCN3/NOV
Japanese Dental Science Review, 2008 Osteoblasts originate from common progenitors, which are capable of differentiating into other mesenchymal cell lineages such as chondrocytes, myoblasts and adipocytes.
Akira Yamaguchi +4 more
doaj +1 more source
Protein palmitoylation regulates osteoblast differentiation through BMP-induced osterix expression. [PDF]
PLoS ONE, 2009 Osteoporosis is one of the most common diseases and can be treated by either anti-resorption drugs, anabolic drugs, or both. To search for anabolic drug targets for osteoporosis therapy, it is crucial to understand the biology of bone forming cells ...
Wai Fook Leong +3 more
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Myocyte enhancer factor 2C: an osteoblast transcription factor identified by DMSO enhanced mineralization [PDF]
, 2011 Free to read on publisher website Rapid mineralization of cultured osteoblasts could be a useful characteristic in stem-cell mediated therapies for fracture and other orthopaedic problems. Dimethyl sulfoxide (DMSO) is a small amphipathic solvent molecule
Bacic-Welsh, Desa +6 more
core +2 more sources
p38 MAPK Signaling in Osteoblast Differentiation [PDF]
Frontiers in Cell and Developmental Biology, 2016 The skeleton is a highly dynamic tissue whose structure relies on the balance between bone deposition and resorption. This equilibrium, which depends on osteoblast and osteoclast functions, is controlled by multiple factors that can be modulated post-translationally.
Rodríguez Carballo, Edgardo +2 more
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SLC38A2 provides proline and alanine to regulate postnatal bone mass accrual in mice
Frontiers in Physiology, 2022 Amino acids have recently emerged as important regulators of osteoblast differentiation and bone formation. Osteoblasts require a continuous supply of amino acids to sustain biomass production to fuel cell proliferation, osteoblast differentiation and ...
Leyao Shen +4 more
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Local origins impart conserved bone type-related differences in human osteoblast behaviour [PDF]
, 2015 Osteogenic behaviour of osteoblasts from trabecular, cortical and subchondral bone were examined to determine any bone type-selective differences in samples from both osteoarthritic (OA) and osteoporotic (OP) patients.
Clarkin, C E +6 more
core +3 more sources
Hyaluronan inhibits BMP‐induced osteoblast differentiation [PDF]
FEBS Letters, 2015 Hyaluronan (HA), one of the major structural extracellular components in cartilage, regulates cellular responses via receptors such as CD44. However, the direct effects of HA on osteoblastic differentiation has not been studied in detail. Here, we investigated the effects of HA (molecular weight: 900–1200kDa) on osteoblastic differentiation that was ...
Kaneko, Keiko +6 more
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