Results 21 to 30 of about 122,840 (307)
Differential Iron Requirements for Osteoblast and Adipocyte Differentiation
JBMR Plus, 2021 ABSTRACT Bone marrow mesenchymal progenitor cells are precursors for various cell types including osteoblasts, adipocytes, and chondrocytes. The external environment and signals act to direct the pathway of differentiation. Importantly, situations such as aging and chronic kidney disease display alterations in the
Daniel F. Edwards +7 more
openaire +4 more sources
MiR-33a Controls hMSCS Osteoblast Commitment Modulating the Yap/Taz Expression Through EGFR Signaling Regulation [PDF]
, 2019 Mesenchymal stromal cells (hMSCs) display a pleiotropic function in bone regeneration. The signaling involved in osteoblast commitment is still not completely understood, and that determines the failure of current therapies being used.
Alessandro, Riccardo +9 more
core +1 more source
E3 Ubiquitin Ligase-Mediated Regulation of Osteoblast Differentiation and Bone Formation
Frontiers in Cell and Developmental Biology, 2021 The ubiquitin–proteasome system (UPS) is an essential pathway that regulates the homeostasis and function of intracellular proteins and is a crucial protein-degradation system in osteoblast differentiation and bone formation.
Jianlin Shen +11 more
doaj +1 more source
Biology Open, 2019 Impaired osteoblast differentiation may result in bone metabolic diseases such as osteoporosis. It was reported recently that hedgehog (Hh) signaling and autophagy are two important regulators of bone differentiation.
Zhanying Hu, Bo Chen, Qiong Zhao
doaj +1 more source
The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis. [PDF]
, 2018 Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs).
Li, Shengwen Calvin +6 more
core +2 more sources
Biphasic regulation of osteoblast development via the ERK MAPK–mTOR pathway
eLife, 2022 Emerging evidence supports that osteogenic differentiation of skeletal progenitors is a key determinant of overall bone formation and bone mass. Despite extensive studies showing the function of mitogen-activated protein kinases (MAPKs) in osteoblast ...
Jung-Min Kim +8 more
doaj +1 more source
FOXO1 modulates osteoblast differentiation
Bone, 2011 Forkhead box O1 (FOXO1) is upregulated during bone formation and in response to stimulation by bone morphogenetic proteins. Studies presented here examined the functional role of FOXO1 in a well defined culture system in which pre-osteoblastic cells undergo terminal differentiation in vitro. Mineralizing cultures of MC3T3-E1 cells were examined with or
Siqueira, Michelle F +8 more
openaire +4 more sources
BMC Musculoskeletal Disorders, 2020 Background The differentiation of human stromal (mesenchymal) stem cells (hMSCs) is a critical procedure for the development of osteoblast. SNHG14 is a newly discovered lncRNA that has been barely studied.
Mingchang Du +5 more
doaj +1 more source
BMC Oral Health, 2021 Background The dentin is a tissue, which is formed by odontoblasts at the pulp interface of the teeth that supports the enamel. Odontoblasts, the cranial neural crest cells are derived from ectodermal mesenchymal stem cells (MSCs) and are long and ...
Young-Bum Son +8 more
doaj +1 more source
eLife, 2022 Cellular differentiation is associated with the acquisition of a unique protein signature that is essential to attain the ultimate cellular function and activity of the differentiated cell.
Leyao Shen +5 more
doaj +1 more source