Results 31 to 40 of about 942,824 (250)

E3 Ubiquitin Ligase-Mediated Regulation of Osteoblast Differentiation and Bone Formation

Frontiers in Cell and Developmental Biology, 2021
The ubiquitin–proteasome system (UPS) is an essential pathway that regulates the homeostasis and function of intracellular proteins and is a crucial protein-degradation system in osteoblast differentiation and bone formation.
Jianlin Shen, Jianlin Shen, Bowen Fu, Yanfang Li, Yanjiao Wu, Hongxun Sang, Heshi Zhang, Haibin Lin, Huan Liu, Wenhua Huang, Wenhua Huang, Wenhua Huang   +11 more
doaj   +1 more source

Hedgehog signaling regulates osteoblast differentiation in zebrafish larvae through modulation of autophagy

Biology Open, 2019
Impaired osteoblast differentiation may result in bone metabolic diseases such as osteoporosis. It was reported recently that hedgehog (Hh) signaling and autophagy are two important regulators of bone differentiation.
Zhanying Hu, Bo Chen, Qiong Zhao
doaj   +1 more source

Biphasic regulation of osteoblast development via the ERK MAPK–mTOR pathway

eLife, 2022
Emerging evidence supports that osteogenic differentiation of skeletal progenitors is a key determinant of overall bone formation and bone mass. Despite extensive studies showing the function of mitogen-activated protein kinases (MAPKs) in osteoblast ...
Jung-Min Kim, Yeon-Suk Yang, Jaehyoung Hong, Sachin Chaugule, Hyonho Chun, Marjolein CH van der Meulen, Ren Xu, Matthew B Greenblatt, Jae-hyuck Shim   +8 more
doaj   +1 more source

SNHG14 induces osteogenic differentiation of human stromal (mesenchymal) stem cells in vitro by downregulating miR-2861

BMC Musculoskeletal Disorders, 2020
Background The differentiation of human stromal (mesenchymal) stem cells (hMSCs) is a critical procedure for the development of osteoblast. SNHG14 is a newly discovered lncRNA that has been barely studied.
Mingchang Du, Bo Wu, Shiwen Fan, Ye Liu, Xu Ma, Xun Fu   +5 more
doaj   +1 more source

Evaluation of odonto/osteogenic differentiation potential from different regions derived dental tissue stem cells and effect of 17β-estradiol on efficiency

BMC Oral Health, 2021
Background The dentin is a tissue, which is formed by odontoblasts at the pulp interface of the teeth that supports the enamel. Odontoblasts, the cranial neural crest cells are derived from ectodermal mesenchymal stem cells (MSCs) and are long and ...
Young-Bum Son, Young-Hoon Kang, Hyeon-Jeong Lee, Si-Jung Jang, Dinesh Bharti, Sung-Lim Lee, Byeong-Gyun Jeon, Bong-Wook Park, Gyu-Jin Rho   +8 more
doaj   +1 more source

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice [PDF]

, 2010
Nearly every extracellular ligand that has been found to play a role in regulating bone biology acts, at least in part, through MAPK pathways. Nevertheless, much remains to be learned about the contribution of MAPKs to osteoblast biology in vivo. Here we
Zhai, Bo, Weiguo Zou, Shim, Jae-Hyuck, Hu, Dorothy, Lotinun, Sutada, Glimcher, Laurie H., Arthur, Simon; id_orcid, Michael D. Schneider, Yasuyo Sano, Min Xie, Matthew B. Greenblatt, Laurie H. Glimcher, Jae-Hyuck Shim, Roger Davis, Xie, Min, Sano, Yasuyo, Despina Sitara, Schweitzer, Michelle, Park, Jin Mo, Schneider, Michael D., Gygi, Steven, Greenblatt, Matthew B., Baron, Roland, Simon Arthur, Zou, Weiguo, Jin Mo Park, Michelle Schweitzer, Davis, Roger, Roland Baron, Sitara, Despina, Sutada Lotinun, Dorothy Hu, Bo Zhai, Steven Gygi   +33 more
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SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation

eLife, 2022
Cellular differentiation is associated with the acquisition of a unique protein signature that is essential to attain the ultimate cellular function and activity of the differentiated cell.
Leyao Shen, Yilin Yu, Yunji Zhou, Shondra M Pruett-Miller, Guo-Fang Zhang, Courtney M Karner   +5 more
doaj   +1 more source

Identification of genes involved in osteoblast differentiation with an shRNA-based approach [PDF]

, 2009
Mesenchymal stem cells (MSCs) derived from bone marrow and they can differentiate in a variety of cell types, including osteoblasts, adipocytes, chondrocytes, myoblasts, hepatocytes, and neural cells.
Cozzolino, Carmine
core   +1 more source

HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes [PDF]

, 2007
HOXA10 is necessary for embryonic patterning of skeletal elements, but its function in bone formation beyond this early developmental stage is unknown. Here we show that HOXA10 contributes to osteogenic lineage determination through activation of Runx2 ...
van Wijnen, AJ, Stein, JL, Lee, SH, Montecino, M, Montecino, Martin A., Lian, JB, Lee, Suk Hee, Stein, Janet L., Hassan, MQ, Van Wijnen, Andre J., Mandeville, Matthew, Mandeville, M, Weiner, B, Weiner, Brian, Lian, Jane B., Stein, GS, Tare, Rahul S., Tare, R., Hassan, Mohammad Q., Stein, Gary S.   +19 more
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Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo [PDF]

, 2008
Resident macrophages are an integral component of many tissues and are important in homeostasis and repair. This study examines the contribution of resident tissue macrophages to bone physiology.
Chang, M. K., Kuliwaba, J., Fazzalari, N., Maylin, E., Raggatt, Liza-Jane, Kuliwaba, Julia S., Alexander, K., Hume, D., Schroder, Kate, Maylin, Erin R., Alexander, Kylie A., Maylin, E. R., Fazzalari, Nicola L., Raggatt, L. J., Ripoll, V., Alexander, K. A., Ripoll, V. M., Schroder, K., Ripoll, Vera M, Pettit, A., Raggatt, L., Pettit, Allison R., Kuliwaba, J. S., Fazzalari, N. L., Hume, D. A., Hume, David A., Pettit, A. R., Chang, M., Chang, Ming K.   +28 more
core   +1 more source