Results 31 to 40 of about 71,796 (264)
Molecules and Cells: Bone provides structural support, enables movement, protects internal organs, regulates calcium and phosphorus levels, and contains bone marrow essential for hematopoiesis.
Seung Hye Lee +3 more
doaj +1 more source
Involvement of Prolyl Hydroxylase Domain Protein in the Rosiglitazone-Induced Suppression of Osteoblast Differentiation. [PDF]
PLoS ONE, 2015 Rosiglitazone is a well-known anti-diabetic drug that increases insulin sensitivity via peroxisome proliferator-activated receptor γ (PPARγ) activation, but unfortunately it causes bone loss in animals and humans.
Ju-Hee Kang +7 more
doaj +1 more source
FOXO1 modulates osteoblast differentiation
Bone, 2011 Forkhead box O1 (FOXO1) is upregulated during bone formation and in response to stimulation by bone morphogenetic proteins. Studies presented here examined the functional role of FOXO1 in a well defined culture system in which pre-osteoblastic cells undergo terminal differentiation in vitro. Mineralizing cultures of MC3T3-E1 cells were examined with or
Siqueira, Michelle F +8 more
openaire +4 more sources
Involvement of Phosphodiesterase Isozymes in Osteoblastic Differentiation [PDF]
Journal of Bone and Mineral Research, 2002 Abstract The cyclic monophosphate nucleotides (cyclic adenosine monophosphate [cAMP] and cyclic guanosine monophosphate [cGMP]) are found ubiquitously in mammalian cells and act as second messenger transducers to effect the intracellular actions of a variety of hormones, cytokines, and neurotransmitters.
Shinji, Wakabayashi +5 more
openaire +2 more sources
MoleculesFarnesoid X receptor (FXR), a nuclear receptor, is expressed in calvaria and bone marrow stromal cells and plays a role in bone homeostasis. However, the mechanism of FXR-activated osteoblast differentiation remains unclear.
Ko Fujimori +4 more
doaj +1 more source
SLC1A5 provides glutamine and asparagine necessary for bone development in mice
eLife, 2021 Osteoblast differentiation is sequentially characterized by high rates of proliferation followed by increased protein and matrix synthesis, processes that require substantial amino acid acquisition and production.
Deepika Sharma +4 more
doaj +1 more source
Inhibition of osteoblast differentiation by ritonavir
Biomedical Reports, 2018 Osteoporosis is one of the chronic complications seen in human immunodeficiency virus (HIV)-infected patients, and affects patients at high prevalence. The causes of osteoporosis in HIV-infected patients are multiple, and include chronic HIV infection, living habits such as smoking and alcohol consumption, and antiretroviral drug use.
Wakabayashi, Yoshitaka +5 more
openaire +3 more sources
Transcriptional regulation of bone formation by the osteoblast-specific transcription factor Osx
Journal of Orthopaedic Surgery and Research, 2010 Bone formation is a complex developmental process involving the differentiation of mesenchymal stem cells to osteoblasts. Osteoblast differentiation occurs through a multi-step molecular pathway regulated by different transcription factors and signaling ...
Zhang Chi
doaj +1 more source
Journal of Functional Biomaterials, 2023 Background: The events of bone formation and osteoblast/titanium (Ti) interactions may be affected by Hedgehog and Notch signalling pathways. Herein, we investigated the effects of modulation of these signalling pathways on osteoblast differentiation ...
Paola Gomes Souza +7 more
doaj +1 more source
Primary human osteoblasts in response to 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3. [PDF]
PLoS ONE, 2014 The most biologically active metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) has well known direct effects on osteoblast growth and differentiation in vitro. The precursor 25-hydroxyvitamin D3 (25(OH)D3) can affect osteoblast function via conversion to
Karen van der Meijden +6 more
doaj +1 more source