Results 31 to 40 of about 892,989 (253)

FXR Activation Accelerates Early Phase of Osteoblast Differentiation Through COX-2-PGE₂-EP4 Axis in BMP-2-Induced Mouse Mesenchymal Stem Cells

Molecules
Farnesoid X receptor (FXR), a nuclear receptor, is expressed in calvaria and bone marrow stromal cells and plays a role in bone homeostasis. However, the mechanism of FXR-activated osteoblast differentiation remains unclear.
Ko Fujimori, Yusuke Iguchi, Yukiko Yamashita, Keigo Gohda, Naoki Teno   +4 more
doaj   +1 more source

Id4, a new candidate gene for senile osteoporosis, acts as a molecular switch promoting osteoblast differentiation.

PLoS Genetics, 2010
Excessive accumulation of bone marrow adipocytes observed in senile osteoporosis or age-related osteopenia is caused by the unbalanced differentiation of MSCs into bone marrow adipocytes or osteoblasts. Several transcription factors are known to regulate
Yoshimi Tokuzawa, Ken Yagi, Yzumi Yamashita, Yutaka Nakachi, Itoshi Nikaido, Hidemasa Bono, Yuichi Ninomiya, Yukiko Kanesaki-Yatsuka, Masumi Akita, Hiromi Motegi, Shigeharu Wakana, Tetsuo Noda, Fred Sablitzky, Shigeki Arai, Riki Kurokawa, Toru Fukuda, Takenobu Katagiri, Christian Schönbach, Tatsuo Suda, Yosuke Mizuno, Yasushi Okazaki   +20 more
doaj   +1 more source

Dual Effects of Liquiritigenin on the Proliferation of Bone Cells: Promotion of Osteoblast Differentiation and Inhibition of Osteoclast Differentiation [PDF]

, 2015
Bone is constantly controlled by a balance between osteoblastic bone formation and osteoclastic bone resorption. Liquiritigenin is a plant-derived flavonoid and has various pharmacological effects, such as antioxidative, antitumor, and antiinflammatory ...
Fukuma, Yutaka, Iwatake, Mayumi, Uchino, Kaho, Eiko Sakai, Kaho Uchino, Okamoto, Kuniaki, Sakai, Eiko, Tsukuba, Takayuki, Nishishita, Kazuhisa, Kuniaki Okamoto, Yutaka Fukuma, Yoneshima, Erika, Takayuki Tsukuba, Kazuhisa Nishishita, Erika Yoneshima, Mayumi Iwatake   +15 more
core   +1 more source

Different titanium surfaces influence in vitro the biological behavior of SaOS-2 human osteoblast-like cells. [PDF]

, 2009
Osseointegrated dental implants have been successfully used over the past several years, allowing functional replacement of missing teeth. Surface properties of titanium dental implants seem to affect bone cell response.
Capece, Gabriele
core   +1 more source

Involvement of Prolyl Hydroxylase Domain Protein in the Rosiglitazone-Induced Suppression of Osteoblast Differentiation. [PDF]

PLoS ONE, 2015
Rosiglitazone is a well-known anti-diabetic drug that increases insulin sensitivity via peroxisome proliferator-activated receptor γ (PPARγ) activation, but unfortunately it causes bone loss in animals and humans.
Ju-Hee Kang, Hyun Jeong Kwak, Hye-Eun Choi, Juyoung Kim, Sangmee Hong, Ok-Hee Kim, Byung Chul Oh, Hyae Gyeong Cheon   +7 more
doaj   +1 more source

Self-assembling peptide-enriched electrospun polycaprolactone scaffolds promote the h-osteoblast adhesion and modulate differentiation-associated gene expression [PDF]

, 2012
Electrospun polycaprolactone (PCL) is able to support the adhesion and growth of h-osteoblasts and to delay their degradation rate to a greater extent with respect to other polyesters. The drawbacks linked to its employment in regenerative medicine arise
V. Samouillan, Brun, Paola, Castagliuolo, Ignazio, Brun P, Iucci, Giovanna, Brunelli K, Delaunay, Florian, Roso, Martina, Dettin, Monica, Danesin, Roberta, Samouillan, Valérie, G. Iucci, Delaunay F, Ghezzo, Francesca, Samouillan V, Ghezzo F, Castagliuolo I, F. Delaunay, Dettin M., Roso M, Modesti M, Modesti, Michele, Danesin R, Brunelli, Katya   +23 more
core   +1 more source

Transcriptional regulation of bone formation by the osteoblast-specific transcription factor Osx

Journal of Orthopaedic Surgery and Research, 2010
Bone formation is a complex developmental process involving the differentiation of mesenchymal stem cells to osteoblasts. Osteoblast differentiation occurs through a multi-step molecular pathway regulated by different transcription factors and signaling ...
Zhang Chi
doaj   +1 more source

SLC1A5 provides glutamine and asparagine necessary for bone development in mice

eLife, 2021
Osteoblast differentiation is sequentially characterized by high rates of proliferation followed by increased protein and matrix synthesis, processes that require substantial amino acid acquisition and production.
Deepika Sharma, Yilin Yu, Leyao Shen, Guo-Fang Zhang, Courtney M Karner   +4 more
doaj   +1 more source

MicroRNA-146a regulates human foetal femur derived skeletal stem cell differentiation by down-regulating SMAD2 and SMAD3 [PDF]

, 2014
MicroRNAs (miRs) play a pivotal role in a variety of biological processes including stem cell differentiation and function. Human foetal femur derived skeletal stem cells (SSCs) display enhanced proliferation and multipotential capacity indicating ...
Tilman Sanchez-Elsner, Sposito, Nunzia, Stumpf, Patrick S., Sanchez-Elsner, Tilman, Richard O C Oreffo, Wilson, David I., Oreffo, Richard O.C., Oreffo, Richard O C, David I Wilson, Cheung, Kelvin S. C., Cheung, Kelvin S C, Kelvin S C Cheung, Patrick S Stumpf, Nunzia Sposito   +13 more
core   +2 more sources

Effects of Modulation of the Hedgehog and Notch Signaling Pathways on Osteoblast Differentiation Induced by Titanium with Nanotopography

Journal of Functional Biomaterials, 2023
Background: The events of bone formation and osteoblast/titanium (Ti) interactions may be affected by Hedgehog and Notch signalling pathways. Herein, we investigated the effects of modulation of these signalling pathways on osteoblast differentiation ...
Paola Gomes Souza, Leticia Faustino Adolpho, Helena Bacha Lopes, Denise Weffort, Alann Thaffarell Portilho Souza, Fabiola Singaretti Oliveira, Adalberto Luiz Rosa, Marcio Mateus Beloti   +7 more
doaj   +1 more source