Results 51 to 60 of about 942,824 (250)

Effects of Modulation of the Hedgehog and Notch Signaling Pathways on Osteoblast Differentiation Induced by Titanium with Nanotopography

Journal of Functional Biomaterials, 2023
Background: The events of bone formation and osteoblast/titanium (Ti) interactions may be affected by Hedgehog and Notch signalling pathways. Herein, we investigated the effects of modulation of these signalling pathways on osteoblast differentiation ...
Paola Gomes Souza, Leticia Faustino Adolpho, Helena Bacha Lopes, Denise Weffort, Alann Thaffarell Portilho Souza, Fabiola Singaretti Oliveira, Adalberto Luiz Rosa, Marcio Mateus Beloti   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Primary human osteoblasts in response to 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3. [PDF]

PLoS ONE, 2014
The most biologically active metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) has well known direct effects on osteoblast growth and differentiation in vitro. The precursor 25-hydroxyvitamin D3 (25(OH)D3) can affect osteoblast function via conversion to
Karen van der Meijden, Paul Lips, Marjolein van Driel, Annemieke C Heijboer, Engelbert A J M Schulten, Martin den Heijer, Nathalie Bravenboer   +6 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Lactate-induced histone lactylation by p300 promotes osteoblast differentiation.

PLoS ONE, 2023
Lactate, which is synthesized as an end product by lactate dehydrogenase A (LDHA) from pyruvate during anaerobic glycolysis, has attracted attention for its energy metabolism and oxidant effects.
Erika Minami, Kiyohito Sasa, Atsushi Yamada, Ryota Kawai, Hiroshi Yoshida, Haruhisa Nakano, Koutaro Maki, Ryutaro Kamijo   +7 more
doaj   +1 more source

LSD1, Runx1 and Runx2 are expressed abundantly during osteoblast differentiation.

, 2022
Lsd1 expression was stable throughout the differentiation culture of both MC3T3-E1 cells (A) as well as mouse calvarial osteoblasts (B) (n = 3). LSD1 protein expression was abundant and increased during osteoblast differentiation (C) in MC3T3-E1 cells ...
Vappu Nieminen-Pihala (12206736), Cristina Valensisi (3560009), Andre J. van Wijnen (8060810), Kati Tarkkonen (12206730), R. David Hawkins (9606399), Riku Kiviranta (94937), Amel Dudakovic (3491768), Petri Rummukainen (4247122), Rana Al-Majidi (12206733)   +8 more
core   +1 more source

3D‐Printed Titanium Gyroid Scaffold Structure Integrated With Tough Hybrid Materials for Cartilage Replacement

Advanced Engineering Materials, EarlyView.
This study proposes a potential device design for joint cartilage replacement. Silica‐polytetrahydrofuran (SiO2‐PolyTHF) hybrids with customizable mechanical properties were developed to mimic the characteristics of a natural meniscus. These were synthesized through a two‐pot sol–gel hybrid process.
Yu‐Chien Lin, Gloria R. Young, Francesca Tallia, Reece N. Oosterbeek, Shaaz Ghouse, Edward Spiers, Nupur Kohli, Tom Briggs, Marc Masen, Siwei Li, Ren‐Jei Chung, Jonathan R. T. Jeffers, Julian R. Jones   +12 more
wiley   +1 more source

hsa_circ_0026827 Promotes Osteoblast Differentiation of Human Dental Pulp Stem Cells Through the Beclin1 and RUNX1 Signaling Pathways by Sponging miR-188-3p

Frontiers in Cell and Developmental Biology, 2020
Previous studies have found that circular RNA (circRNA) hsa_circ_0026827 plays a role during osteoblast differentiation, but the mechanism is unclear. The aim of this study was to illuminate the role of hsa_circ_0026827 in human dental pulp stem cells ...
Fang Ji, Fang Ji, Lanying Zhu, Jing Pan, Jing Pan, Zhecheng Shen, Zhecheng Shen, Zhao Yang, Zhao Yang, Jian Wang, Jian Wang, Xuebing Bai, Xuebing Bai, Yueting Lin, Yueting Lin, Jiang Tao, Jiang Tao   +16 more
doaj   +1 more source

In Vitro Comparison of Macrophage Polarization and Osteoblast Differentiation Potentials between Granules and Block Forms of Deproteinized Bovine Bone Mineral. [PDF]

, 2020
Deproteinized bovine bone mineral (DBBM) bone grafts are commonly utilized for guided bone regeneration (GBR) techniques in regenerative dentistry. It has been hypothesized that different forms (blocks versus particulates) might demonstrate the varying ...
Miron, Richard J., Masako Fujioka-Kobayashi, Benoit Schaller, Simon D. Marjanowski, Richard J. Miron, Katagiri, Hiroki, Schaller, Benoit, Kono, Michihide, Michihide Kono, Marjanowski, Simon D., Fujioka-Kobayashi, Masako, Hiroki Katagiri, Schaller B, Katagiri H, Kono M, Marjanowski SD, Miron RJ, Fujioka-Kobayashi M   +17 more
core   +2 more sources