Results 71 to 80 of about 892,989 (253)
Cell Reports, 2016 The E3 ubiquitin ligase Smurf1 targets the master regulator of osteoblast differentiation, Runx2, for degradation, yet the function of Smurf1, if any, during osteoblast differentiation in vivo is ill defined. Here, we show that Smurf1 prevents osteoblast
Junko Shimazu +2 more
doaj +1 more source
Advanced Science, EarlyView.Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He +9 more
wiley +1 more source
Behavior of osteoblastic cells cultured on titanium and structured zirconia surfaces [PDF]
, 2008 Background Osseointegration is crucial for the long-term success of dental implants and depends on the tissue reaction at the tissue-implant interface.
Ulrich Meyer +23 more
core +2 more sources
Differentiation and function of osteoblast [PDF]
, 2001 Elucidation of molecular mechanisms controlling differentiation and function of osteoblasts is one of the major subjects in bone biology. Differentiation of cells is controlled at the level of transcription by various classes of transcription factors ...
田村, 正人, TAMURA, Masato
core +1 more source
Cell DiscoveryThe initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo differentiation into osteoblasts. This differentiation process plays a crucial role in bone formation and homeostasis and is regulated by two intricate processes: cell ...
Siyu Zhu +3 more
doaj +1 more source
Melatonin promotes osteoblast differentiation by regulating Osterix protein stability and expression
Scientific Reports, 2017 Although the biological role of melatonin in osteogenic differentiation has been suggested, the mechanism of osteoblast differentiation remains unclear. Thus, the present study investigated the underlying molecular mechanisms based on osteoblast-specific
Younho Han +3 more
doaj +1 more source
Advanced Science, EarlyView.GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han +16 more
wiley +1 more source
FGF and TGFbeta signalling in an in-vitro model of craniosynostosis [PDF]
, 2009 Fibroblast Growth Factor (FGF) and Transforming Growth Factor beta (TGFbeta) are key regulators of bone development. Constitutively activating mutations of FGF Receptors (FGFR) 1-3 result in craniosynostosis, premature fusion of cranial sutures.
Lee, K.M.A.
core
Journal of Oral Biology and Craniofacial Research, 2020 Objective: To define the effect of Jagged1 on the gene expression in osteoblast differentiation, regulation of osteoblast differentiation and regulation of bone mineralization ontology.
Kanokporn Hansamuit +2 more
doaj +1 more source
Differential expression of claudin family members during osteoblast and osteoclast differentiation: Cldn-1 is a novel positive regulator of osteoblastogenesis. [PDF]
PLoS ONE, 2014 Claudins (Cldns), a family of 27 transmembrane proteins, represent major components of tight junctions. Aside from functioning as tight junctions, Cldns have emerging roles as regulators of cell proliferation and differentiation. While Cldns are known to
Fatima Z Alshbool, Subburaman Mohan
doaj +1 more source