Results 61 to 70 of about 892,989 (253)

CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation

, 2015
The positive roles of the Wnt/β-catenin pathway in osteoblast differentiation and bone mineral density (BMD) maintenance have been clearly demonstrated in both animal experiments and clinical investigations.
정한성, 이유미
core   +1 more source

IGFBP‐2 Directly Stimulates Osteoblast Differentiation [PDF]

, 2014
Insulin like growth factor binding protein two (IGFBP-2) is important for acquisition of normal bone mass in mice; however, the mechanism by which IGFBP-2 functions is not defined.
Wai, Christine, DeMambro, Victoria, Clemmons, David R, Gang Xi, Victoria DeMambro, David R Clemmons, Christine Wai, Xi, Gang, Clifford J Rosen, Rosen, Clifford J   +9 more
core   +1 more source

Cyclophilin A Promotes Osteoblast Differentiation by Regulating Runx2

, 2022
Cyclophilin A (CypA) is a ubiquitously expressed and highly conserved protein with peptidyl-prolyl cis-trans isomerase activity that is involved in various biological activities by regulating protein folding and trafficking.
Joong-Kook Choi, Piao, Meiyu, Choi, Joong-Kook, Kim, Myeong Ji, Myeong Ji Kim, Lee, Kwang Youl, Yeo, Chang-Yeol, Chang-Yeol Yeo, Meiyu Piao, Kwang Youl Lee, Lee, Sung Ho, Sung Ho Lee   +11 more
core   +1 more source

Early B-cell Factor1 (Ebf1) promotes early osteoblast differentiation but suppresses osteoblast function [PDF]

, 2022
Early B cell factor 1 (Ebf1) is a transcription factor that regulates B cell, neuronal cell and adipocyte differentiation. We and others have shown that Ebf1 is expressed in osteoblasts and that global deletion of Ebf1 results in increased bone formation
Tarkkonen Kati, Saastamoinen Lauri, Nieminen-Pihala Vappu, Rummukainen Petri, Nagano Kenichi, Kiviranta Riku, Laine Julius, Baron Roland   +7 more
core   +1 more source

BMP2-dependent gene regulatory network analysis reveals Klf4 as a novel transcription factor of osteoblast differentiation

Cell Death and Disease, 2021
Transcription factors (TFs) regulate the expression of target genes, inducing changes in cell morphology or activities needed for cell fate determination and differentiation.
Shuaitong Yu, Jinqiang Guo, Zheyi Sun, Chujiao Lin, Huangheng Tao, Qian Zhang, Yu Cui, Huanyan Zuo, Yuxiu Lin, Shuo Chen, Huan Liu, Zhi Chen   +11 more
doaj   +1 more source

Biomimetic Gradient Hydrogels Regulate Osteochondral Regeneration Microenvironment Remodeling via Spatiotemporal Programming Engineering

Advanced Science, EarlyView.
Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu, Shengzhao Xiao, Di Huang, Xuesong Wang, Yanwei Cao, Xiaodan Sun, Nicholas Dunne, Xiaoming Li   +7 more
wiley   +1 more source

Osteoarthritic cartilage chondrocytes alter subchondral bone osteoblast\ud differentiation via MAPK signalling pathway involving ERK1/2

, 2010
Osteoarthritic subchondral bone is characterized by abnormal bone density and enhanced production of\ud bone turnover markers, an indication of osteoblast dysfunction.
Shi, Wei, Friis, Thor, Prasadam, Indira, Crawford, Ross, Xiao, Yin, van Gennip, Stijn   +5 more
core   +1 more source

The MCP-3/Ccr3 axis contributes to increased bone mass by affecting osteoblast and osteoclast differentiation

Experimental and Molecular Medicine
Several CC subfamily chemokines have been reported to regulate bone metabolism by affecting osteoblast or osteoclast differentiation. However, the role of monocyte chemotactic protein 3 (MCP-3), a CC chemokine, in bone remodeling is not well understood ...
Jung Ha Kim, Kabsun Kim, Inyoung Kim, Semun Seong, Xiangguo Che, Je-Yong Choi, Jeong-Tae Koh, Nacksung Kim   +7 more
doaj   +1 more source

Unraveling Bone‐Skin Crosstalk Enables miRNA Nanoformulation for Cutaneous Neurovascular Reconstruction in Diabetic Mice

Advanced Science, EarlyView.
This study unravels that bone fracture accelerates diabetic wound healing by releasing exosomal microRNA (miR‐130b‐3p). To mimic this bone‐skin crosstalk, we engineered a self‐assembling agomir‐130b‐3p nanocomplex. Delivered via a photocrosslinkable hydrogel, this bio‐inspired therapy provides sustained localized agomir release.
Tao Shen, Hongdou Shen, Weiyue Wu, Zhuoying Jiang, Bin Liu, Yansi Xian, Rui Peng, An Yan, Yu Ben, Yong Shi, Xiang Chen, Baosheng Guo, Qing Jiang, Weijun Wang, Pingqiang Cai   +14 more
wiley   +1 more source

Epigenetic regulation of osteoblast differentiation [PDF]

, 2016
Proper temporal epigenetic regulation of gene expression is essential for cell fate determination and tissue development. However, epigenetic mechanisms involved in control of bone-specific transcriptional programs remain largely unexplored.
Najafova, Zeynab
core   +1 more source