Results 61 to 70 of about 942,824 (250)

Hybrid Biofabrication of a Hierarchically Organized Periosteum‐Inspired In Vitro Platform

Advanced Healthcare Materials, EarlyView.
A hybrid biofabrication strategy integrates melt electrowriting with extrusion‐based 3D bioprinting to create a hierarchically organized periosteum‐inspired in vitro platform. Spatially defined osteogenic, fibrous, and endothelial cell‐containing compartments support long‐term culture, osteogenic maturation, and CD31+ endothelial cell organization ...
Yakui Liu, Xinggui Tian, Anne Bernhardt, Anja Lode, Max von Witzleben, Ege Kirbas, Stefan Zwingenberger, Michael Gelinsky   +7 more
wiley   +1 more source

Bone Organoids Across the Development‐to‐Remodeling Continuum: From Tissue Formation to Functional Competence and Translation

Advanced Healthcare Materials, EarlyView.
Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang, Haijia Xu, Xiangzhong Liu, Yi Yang, Zhanghua Li   +4 more
wiley   +1 more source

Molecular mechanisms of BMP-induced bone formation: Cross-talk between BMP and NF-κB signaling pathways in osteoblastogenesis

Japanese Dental Science Review, 2010
Osteoblasts are bone-forming cells that differentiate from mesenchymal stem cells. Differentiation processes are coordinately and dynamically controlled in the mesenchymal cells by specific signal transduction pathways. Bone morphogenetic proteins (BMPs),
Eijiro Jimi, Shizu Hirata, Masashi Shin, Masato Yamazaki, Hidefumi Fukushima   +4 more
doaj   +1 more source

CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation

, 2015
The positive roles of the Wnt/β-catenin pathway in osteoblast differentiation and bone mineral density (BMD) maintenance have been clearly demonstrated in both animal experiments and clinical investigations.
정한성, 이유미
core   +1 more source

GaSex Nanoparticles Modulate Neutrophil Function and Mitigate NET‐Driven Osteogenic Impairment in Osteomyelitis Therapy

Advanced Materials, EarlyView.
Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye, Xuanzhe Liu, Zifan Pei, Chenyi Jiang, Xiaofen Zhang, Lin Lin, Qihang Fang, Binyu Chen, Longxiang Shen, Liang Cheng, Peng Ding, Xianyou Zheng   +11 more
wiley   +1 more source

Eucommia ulmoides Oliver polysaccharide alleviates glucocorticoid-induced osteoporosis by stimulating bone formation via ERK/BMP-2/SMAD signaling

Scientific Reports
Osteoporosis (OP) is a metabolic disease characterized by low bone mineral mass owing to osteoblast dysfunction. Eucommia ulmoides Oliver (EuO) is a Chinese herbal medicine traditionally used to treat OP.
Jiyu Song, Yongfeng Zhang, Xinghui Jin, Yanfeng Zhu, Yutong Li, Min Hu   +5 more
doaj   +1 more source

Osteoblast differentiation and migration are regulated by Dynamin GTPase activity [PDF]

, 2014
Bone formation is controlled by osteoblasts but the signaling proteins that control osteoblast differentiation and function are still unclear. We examined if the dynamin GTPase, which is associated with actin remodeling and migration in other cells ...
Bruzzaniti, Angela, Largura, Heather W., Huang, Su, Eleniste, Pierre P., Wayakanon, Kornchanok   +4 more
core   +1 more source

Graphene Layers as Functional Biomaterials. From Fabrication and Characterization to Biological Applications

Advanced Materials Interfaces, EarlyView.
Graphene layers are fabricated on Cu foil and transferred onto glass substrates to form double‐ and multi‐layer G‐glass. Raman spectroscopy confirms structural integrity, while SEM and fluorescence microscopy reveal favorable adhesion and spreading of L‐929 fibroblast cells.
Mariana Mihaela Apostol, Issam Boukhoubza, Daniela Oprea, Iulia Corina Ciobotaru, Catalin Negrila, Ionut Enculescu, Ecaterina Andronescu, Teodor Adrian Enache, Elena Matei   +8 more
wiley   +1 more source

Hedgehog signaling in tumor cells facilitates osteoblast-enhanced osteolytic metastases. [PDF]

PLoS ONE, 2012
The remodeling process in bone yields numerous cytokines and chemokines that mediate crosstalk between osteoblasts and osteoclasts and also serve to attract and support metastatic tumor cells.
Shamik Das, J Allan Tucker, Shikha Khullar, Rajeev S Samant, Lalita A Shevde   +4 more
doaj   +1 more source

Plumbagin modulates RANKL-induced osteoclast and osteoblast differentiation

, 2023
Background: Bone remodeling is a balanced, dynamic function of two counteractive processes: osteoblasts-mediated bone formation and osteoclasts-dependent bone resorption. An imbalance between these two processes causes bone diseases.
Vitthal T. Barvkar, Bhaskar Saha, Suhas T. Mhaske, Soni Ghumnani, Richa Ashma   +4 more
core   +1 more source