Results 81 to 90 of about 942,824 (250)

Melatonin promotes osteoblast differentiation by regulating Osterix protein stability and expression

Scientific Reports, 2017
Although the biological role of melatonin in osteogenic differentiation has been suggested, the mechanism of osteoblast differentiation remains unclear. Thus, the present study investigated the underlying molecular mechanisms based on osteoblast-specific
Younho Han, Young-Mi Kim, Hyung Sik Kim, Kwang Youl Lee   +3 more
doaj   +1 more source

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis

Advanced Science, EarlyView.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su, Ye Tian, Fan Zhao, Jing Li, Suryaji Patil, Chunyu Zhu, Yujia Tian, Junrong Wang, Jiating Liu, Aoqi Xiang, Hua Guan, Lusha Zhang, Xiaochang Chen, Airong Qian, Qi Yu   +14 more
wiley   +1 more source

Effect of Jagged1 on the expression of genes in regulation of osteoblast differentiation and bone mineralization ontology in human dental pulp and periodontal ligament cells

Journal of Oral Biology and Craniofacial Research, 2020
Objective: To define the effect of Jagged1 on the gene expression in osteoblast differentiation, regulation of osteoblast differentiation and regulation of bone mineralization ontology.
Kanokporn Hansamuit, Thanaphum Osathanon, Jaijam Suwanwela   +2 more
doaj   +1 more source

Differential expression of claudin family members during osteoblast and osteoclast differentiation: Cldn-1 is a novel positive regulator of osteoblastogenesis. [PDF]

PLoS ONE, 2014
Claudins (Cldns), a family of 27 transmembrane proteins, represent major components of tight junctions. Aside from functioning as tight junctions, Cldns have emerging roles as regulators of cell proliferation and differentiation. While Cldns are known to
Fatima Z Alshbool, Subburaman Mohan
doaj   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

Royal Jelly Enhances the Ability of Myoblast C2C12 Cells to Differentiate into Multilineage Cells

Molecules
Royal jelly (RJ) is recognized as beneficial to mammalian health. Multilineage differentiation potential is an important property of mesenchymal stem cells (MSCs). C2C12 cells have an innate ability to differentiate into myogenic cells.
Takumi Ito, Thira Rojasawasthien, Sachiko Yamashita Takeuchi, Hideto Okamoto, Nobuaki Okumura, Tomohiko Shirakawa, Takuma Matsubara, Tatsuo Kawamoto, Shoichiro Kokabu   +8 more
doaj   +1 more source

SSH-BM-I, a Tryptamine Derivative, Stimulates Mineralization in Terminal Osteoblast Differentiation but Inhibits Osteogenesis of Pre-committed Progenitor Cells

Journal of Pharmacological Sciences, 2011
.: SSH-BM-I was synthesized from tryptamine by using a newly developed synthetic method, and it has structural similarity to bromomelatonin. Recently, it had been reported that SSH-BM-I increases osteoblasts in scales of gold fish. However, the effect of
Yoshikazu Mikami, Masanori Somei, Hiromasa Tsuda   +2 more
doaj   +1 more source

Proposed mechanistic scheme of T-cell mediated osteoblast differentiation and maturation.

, 2013
Upstream IL-6 increase early post fracture promotes naïve CD4+ T-cells to Th17 cells stimulating pre-osteoblast cell differentiation via IL-17F. Concomitantly, the Treg pathway is suppressed, decreasing TGFβ and IL-10 and inhibiting pre-osteoblast ...
Yufa Wang (317537), David Silkstone (317539), Diane Nam (317535), Elaine Mau (317536), Heather Whetstone (317541), Benjamin Alman (153486), David Wright (116911), Cari Whyne (317543)   +7 more
core   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Akt enhances Runx2 protein stability by regulating Smurf2 function during osteoblast differentiation

, 2019
Akt; differentiation; osteoblast; Runx2 ...
여창열
core   +1 more source