Results 101 to 110 of about 892,989 (253)

A Twist Code Determines the Onset of Osteoblast Differentiation [PDF]

, 2004
Runx2 is necessary and sufficient for osteoblast differentiation, yet its expression precedes the appearance of osteoblasts by 4 days. Here we show that Twist proteins transiently inhibit Runx2 function during skeletogenesis. Twist-1 and -2 are expressed
Schrock, Marijke, Wu, Hua, Yang, Xiangli, Ornitz, David M, Olson, Eric N, Kern, Britt, Sosic, Drazen, Bialek, Peter, Karsenty, Gerard, Hong, Nancy, Yu, Kai, Justice, Monica J   +11 more
core   +1 more source

The Role of Follistatin-like 1 in the Cross-Talk Among Osteoclastogenesis, Bone Marrow Stromal Cell Migration, and Osteoblastogenesis In Vitro

Biomedicines
Background: Bone remodeling depends on the dynamic balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. Follistatin-like 1 (FSTL1) has been reported as an osteoclast-secreted protein that inhibits osteoclast ...
Yongxu Piao, Xiangguo Che, Xian Jin, Dong-Kyo Lee, Min Park, Eun-Jung Heo, Jinyoung Oh, Seong-Gon Kim, Dae-Chul Cho, Hyun-Ju Kim, Je-Yong Choi   +10 more
doaj   +1 more source

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

Premature Osteoblast Clustering by Enamel Matrix Proteins Induces Osteoblast Differentiation through Up-Regulation of Connexin 43 and N-Cadherin [PDF]

, 2011
In recent years, enamel matrix derivative (EMD) has garnered much interest in the dental field for its apparent bioactivity that stimulates regeneration of periodontal tissues including periodontal ligament, cementum and alveolar bone.
Zhang, Yufeng, Buser Daniel, Hedbom Erik, Gemperli Anja C., Ruggiero, Sabrina, Mauth Corinna, Ruggiero Sabrina, Gemperli, Anja C, Yufeng Zhang, Tateyuki Iizuka, Daniel Buser, Miron, Richard, Bosshardt Dieter D., Richard J. Miron, Anja C. Gemperli, Iizuka Tateyuki, Richard J Miron, Erik Hedbom, Corinna Mauth, Sculean Anton, Iizuka, Tateyuki, Anton Sculean, Hedbom, Erik, Zhang Yufeng, Sabrina Ruggiero, Miron Richard J., Buser, Daniel, Anja C Gemperli, Dieter D Bosshardt, Sculean, Anton, Mauth, Corinna, Bosshardt, Dieter, Dieter D. Bosshardt   +32 more
core   +3 more sources

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis

Advanced Science, EarlyView.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su, Ye Tian, Fan Zhao, Jing Li, Suryaji Patil, Chunyu Zhu, Yujia Tian, Junrong Wang, Jiating Liu, Aoqi Xiang, Hua Guan, Lusha Zhang, Xiaochang Chen, Airong Qian, Qi Yu   +14 more
wiley   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

KIAA0753 enhances osteoblast differentiation suppressed by diabetes. [PDF]

J Cell Mol Med
Diabetes-related bone loss represents a significant complication that persistently jeopardizes the bone health of individuals with diabetes. Primary cilia proteins have been reported to play a vital role in regulating osteoblast differentiation in ...
Li M, Wang Y, Wu X, Chen Q, Huang J, Zhu H, Yang S, Wang J, Li LT, Liu X, Fu K, Song F, Wang C.   +12 more
europepmc   +2 more sources

Regulatory Mechanism of Osteoblast Differentiation and Bone Formation [PDF]

, 2000
Osteoblast differentiation is regulated by various hormones and local factors such as estrogen, parathyroid hormone, bone morphogenetic proteins (BMPs) and hedgehogs.
Yamaguchi, Akira
core   +1 more source

MiR-214 Attenuates Osteogenic Differentiation of Mesenchymal Stem Cells via Targeting FGFR1

Cellular Physiology and Biochemistry, 2016
Background/Aims: Postmenopausal osteoporosis is closely associated with reduction in the differentiation of mesenchymal stem cells (MSCs) into osteoblasts.
Lei Yang, Dawei Ge, Xiaojian Cao, Yingbin Ge, Hongtao Chen, Weiwei Wang, Hongxiu Zhang   +6 more
doaj   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source