Results 31 to 40 of about 115,464 (311)

Neural Cell Adhesion Molecule Regulates Osteoblastic Differentiation Through Wnt/β-Catenin and PI3K-Akt Signaling Pathways in MC3T3-E1 Cells

Frontiers in Endocrinology, 2021
Neural cell adhesion molecule (NCAM) is involved in cell multi-directional differentiation, but its role in osteoblast differentiation is still poorly understood.
Bin-Feng Cheng, Xiao Feng, Yao-Xin Gao, Shao-Qin Jian, Shi-Rao Liu, Mian Wang, Yun-Fei Xie, Lei Wang, Zhi-Wei Feng, Hai-Jie Yang, Hai-Jie Yang   +10 more
doaj   +1 more source

Osteoblast origins and occurrences. [PDF]

, 2021
Osteoblast origins and occurrences.
Bregje W. M. de Wildt (11648899), Eva S. R. Spaander (11648905), Stefan J. A. Remmers (11648896), Rob B. M. de Vries (11648908), Michelle A. M. Vis (11648902), Sandra Hofmann (488242), Keita Ito (446796)   +6 more
core   +1 more source

Osteoblast Differentiation at a Glance [PDF]

Medical Science Monitor Basic Research, 2016
Ossification is a tightly regulated process, performed by specialized cells called osteoblasts. Dysregulation of this process may cause inadequate or excessive mineralization of bones or ectopic calcification, all of which have grave consequences for human health.
Rutkovskiy, Arkady, Stensløkken, Kåre-Olav, Vaage, Ingvar Jarle   +2 more
openaire   +2 more sources

TMEM175 plays a crucial role in osteoblast differentiation by regulating lysosomal function and autophagy

Molecules and Cells
: Bone provides structural support, enables movement, protects internal organs, regulates calcium and phosphorus levels, and contains bone marrow essential for hematopoiesis.
Seung Hye Lee, Ji Sun Jang, Shenzheng Mo, Hong-Hee Kim   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Osteoarthritic cartilage chondrocytes alter subchondral bone osteoblast\ud differentiation via MAPK signalling pathway involving ERK1/2 [PDF]

, 2010
Osteoarthritic subchondral bone is characterized by abnormal bone density and enhanced production of\ud bone turnover markers, an indication of osteoblast dysfunction.
Shi, Wei, Friis, Thor, Prasadam, Indira, Crawford, Ross, Xiao, Yin, van Gennip, Stijn   +5 more
core   +1 more source

FXR Activation Accelerates Early Phase of Osteoblast Differentiation Through COX-2-PGE₂-EP4 Axis in BMP-2-Induced Mouse Mesenchymal Stem Cells

Molecules
Farnesoid X receptor (FXR), a nuclear receptor, is expressed in calvaria and bone marrow stromal cells and plays a role in bone homeostasis. However, the mechanism of FXR-activated osteoblast differentiation remains unclear.
Ko Fujimori, Yusuke Iguchi, Yukiko Yamashita, Keigo Gohda, Naoki Teno   +4 more
doaj   +1 more source

SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts

Nature Communications, 2017
The balance between osteoclast and osteoblast-mediated bone turnover is essential for bone health and homeostasis. Here the authors show that both germline and osteoblast-specificSmurf2-deficient mice have osteoporosis as a result of increased osteoblast
Zhan Xu, Matthew B. Greenblatt, Guang Yan, Heng Feng, Jun Sun, Sutada Lotinun, Nicholas Brady, Roland Baron, Laurie H. Glimcher, Weiguo Zou   +9 more
doaj   +1 more source

Inhibition of Osteoblast Function by Brucella abortus is Reversed by Dehydroepiandrosterone and Involves ERK1/2 and Estrogen Receptor

Frontiers in Immunology, 2018
Brucella abortus induces an inflammatory response that stimulates the endocrine system resulting in the secretion of cortisol and dehydroepiandrosterone (DHEA).
María Virginia Gentilini, Ayelén Ivana Pesce Viglietti, Paula Constanza Arriola Benitez, Andrea Elena Iglesias Molli, Gloria Edith Cerrone, Guillermo Hernán Giambartolomei, María Victoria Delpino   +6 more
doaj   +1 more source

Strontium and osteoblast function [PDF]

Osteoporosis International, 2015
Dear Editor, We thank Drs. Xie and Ye [1] for their interest in our paper [2] and address their main comments below. Firstly, we were careful to acknowledge the contrasting findings of other published studies, both in vitro and in vivo. We do not know of any evidence to support the assertion of Drs.
D P, Wornham, M O, Hajjawi, I R, Orriss, T R, Arnett   +3 more
openaire   +2 more sources