Results 1 to 10 of about 38,639 (266)

Di-ethanolamine Might Cause Bone-related Complications Due to the Reduction of Osteogenic Differentiation and Induction of Oxidative Stress [PDF]

Journal of Genetic Resources, 2020
Di-ethanolamine (DEA) is a well-known environmental pollutant used in manufacturing soap, detergent, body lotion, and other sanitary products. DEA has been reported to cause cytotoxicity in different tissue and cell, but no study was found to explain the
Mohammad Hussein Abnosi, Setarehsadat Hosseini   +1 more
doaj   +1 more source

Alcohol-induced inhibition of bone formation and neovascularization contributes to the failure of fracture healing via the miR-19a-3p/FOXF2 axis

Bone & Joint Research, 2022
Aims: Alcoholism is a well-known detrimental factor in fracture healing. However, the underlying mechanism of alcohol-inhibited fracture healing remains poorly understood.
Daoyu Zhu, Haoyu Fang, Hongping Yu, Pei Liu, Qianhao Yang, Pengbo Luo, Changqing Zhang, Youshui Gao, Yi-Xuan Chen   +8 more
doaj   +1 more source

Hsa_circ_0066523 promotes the proliferation and osteogenic differentiation of bone mesenchymal stem cells by repressing PTEN

Bone & Joint Research, 2021
Aims: Circular RNAs (circRNAs) are a novel type of non-coding RNA that plays major roles in the development of diverse diseases including osteonecrosis of the femoral head (ONFH). Here, we explored the impact of hsa_circ_0066523 derived from forkhead box
Wei Xin, Shuai Yuan, Bo Wang, Qirong Qian, Yi Chen   +4 more
doaj   +1 more source

Interleukin-19 promotes bone resorption by suppressing osteoprotegerin expression in BMSCs in a lipopolysaccharide-induced bone loss mouse model

Bone & Joint Research, 2023
Aims: Osteoporosis is characterized by decreased trabecular bone volume, and microarchitectural deterioration in the medullary cavity. Interleukin-19 (IL-19), a member of the IL-10 family, is an anti-inflammatory cytokine produced primarily by ...
Zhicheng Dai, Yanan Chen, Enjun He, Hongjie Wang, Weihong Guo, Zhenkai Wu, Kai Huang, Qinghua Zhao   +7 more
doaj   +1 more source

MiRNA-21 promotes differentiation of bone marrow mesenchymal stem cells into cardiomyocyte-like cells by regulating the Ajuba/Isl1 axis pathway

Archives of Medical Science, 2022
Introduction In this study, we aimed to investigate the role of miRNA-21 and the regulating pathway that promotes the differentiation of bone marrow mesenchymal stem cells (BMSCs). Material and methods We used miR-21-OE, miR-21-KD, ajuba-OE and ajuba-KD
Wengang Yang, Lei Zhao, Song Xue, Jidong Liu, Jianggui Shan   +4 more
doaj   +1 more source

Reactive oxygen species mediate TNF-α-induced inflammatory response in bone marrow mesenchymal cells [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): It is generally believed that the inflammatory response in bone marrow mesenchymal stem cells (BMSCs) transplantation leads to poor survival and unsatisfactory effects, and is mainly mediated by cytokines, including interleukin-1β (IL-1β ...
Liuzhong Wu, Yaping Pan
doaj   +1 more source

Effect of secretory leucocyte protease inhibitor on early tendon-to-bone healing after anterior cruciate ligament reconstruction in a rat model

Bone & Joint Research, 2022
Aims: To verify whether secretory leucocyte protease inhibitor (SLPI) can promote early tendon-to-bone healing after anterior cruciate ligament (ACL) reconstruction. Methods: In vitro: the mobility of the rat bone mesenchymal stem cells (BMSCs) treated
Yongmao Wu, Yan Shao, Denghui Xie, Jianying Pan, Huabin Chen, Juncheng Yao, Jiarong Liang, Haolin Ke, Daozhang Cai, Chun Zeng   +9 more
doaj   +1 more source

PDE-5-Inhibited BMSCs Alleviate High Glucose-Induced Myocardial Fibrosis and Cardiomyocyte Apoptosis by Activating the cGMP/PKG Pathway

Frontiers in Bioscience-Landmark, 2023
Background: Phosphodiesterase-5 (PDE-5) inhibitors have been found to play an important cardio-protective role. This study aimed to clarify the inhibitory effects of PDE-5-silenced bone marrow mesenchymal stem cells (BMSCs) on high glucose-induced ...
Qinghua Huang, Jiangbo Ma, Hui Wu, Jieru Zhou, Lei Jiang, Xianming Fei   +5 more
doaj   +1 more source

The ratio of VEGF/PEDF expression in bone marrow mesenchymal stem cells regulates neovascularization [PDF]

, 2011
Angiogenesis, or neovascularization, is a finely balanced process controlled by pro- and anti-angiogenic factors. Vascular endothelial growth factor (VEGF) is a major pro-angiogenic factor, whereas pigment epithelial-derived factor (PEDF) is the most ...
Crawford, Ross, Fan, Wei, Xiao, Yin
core   +2 more sources

Crosstalk between CML cells with HUVECs and BMSCs through exosomes

Frontiers in Bioscience-Landmark, 2020
Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm characterized by presence of the BCR-ABL fusion gene which encodes the constitutively active BCR-ABL chimeric protein.
Zafer Cetin, Eyup I. Saygili, Mehmet Yilmaz   +2 more
doaj   +1 more source