Results 41 to 50 of about 45,848 (279)

Macrophage-derived mitochondria-rich extracellular vesicles aggravate bone loss in periodontitis by disrupting the mitochondrial dynamics of BMSCs

Journal of Nanobiotechnology
Periodontitis is the leading cause of tooth loss in adults due to progressive bone destruction, which is closely related to the dysfunction of bone mesenchymal stem cells (BMSCs).
Jiayin Yan, Tian Yang, Siyuan Ma, Danfeng Li, Cheng Hu, Jiali Tan   +5 more
semanticscholar   +1 more source

Injectable Photo-Crosslinked Bioactive BMSCs-BMP2-GelMA Scaffolds for Bone Defect Repair

Frontiers in Bioengineering and Biotechnology, 2022
Injectable hydrogels offer a new therapy option for irregular bone deformities. Based on gelatin methacryloyl (GelMA), bone marrow mesenchymal stem cells (BMSCs), and bone morphogenetic protein 2 (BMP2), we created a photo-crosslinked composite bioactive
Senlin Chai, Jianhao Huang, Abdurahman Mahmut, Bin Wang, Yao Yao, Xiao-fang Zhang, Zaikai Zhuang, Chunmei Xie, Zhihong Xu, Qing Jiang   +9 more
semanticscholar   +1 more source

Progress of bone marrow mesenchymal stem cell transplantation on neural plasticity in brain

Frontiers in Cell and Developmental Biology
Stem cells are cells with strong proliferation and differentiation abilities. Among all stem cells, bone marrow mesenchymal stem cells (BMSCs) have been extensively studied.
Wenjing Li, Wenjing Li, Xiaohua Liu, Jingjing Li   +3 more
doaj   +1 more source

Alpinetin alleviates osteoporosis by promoting osteogenic differentiation in BMSCs by triggering autophagy via PKA/mTOR/ULK1 signaling

Phytotherapy Research, 2022
Osteoporosis, a systemic bone disease that is characterized by a reduction in bone mass and destruction of bone microstructure, is becoming a serious problem worldwide.
Chenying Zeng, Shan Wang, Fenglei Chen, Ziming Wang, Jinteng Li, Zhongyu Xie, M. Ma, Peng Wang, Huiyong Shen, Yanfeng Wu   +9 more
semanticscholar   +1 more source

The Role of Tantalum Nanoparticles in Bone Regeneration Involves the BMP2/Smad4/Runx2 Signaling Pathway

International Journal of Nanomedicine, 2020
Guilan Zhang,1,2 Wenjing Liu,3 Ruolan Wang,1 Yanli Zhang,3 Liangjiao Chen,4 Aijie Chen,3 Haiyun Luo,5 Hui Zhong,1 Longquan Shao1,2 1Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, People’s Republic of ...
Zhang G, Liu W, Wang R, Zhang Y, Chen L, Chen A, Luo H, Zhong H, Shao L   +8 more
doaj  

Apoptosis of bone marrow mesenchymal stem cells caused by homocysteine via activating JNK signal. [PDF]

PLoS ONE, 2013
Bone marrow mesenchymal stem cells (BMSCs) are capable of homing to and repair damaged myocardial tissues. Apoptosis of BMSCs in response to various pathological stimuli leads to the attenuation of healing ability of BMSCs.
Benzhi Cai, Xingda Li, Yang Wang, Yanju Liu, Fan Yang, Hongyang Chen, Kun Yin, Xueying Tan, Jiuxin Zhu, Zhenwei Pan, Baoqiu Wang, Yanjie Lu   +11 more
doaj   +1 more source

Extracellular vesicles from apoptotic BMSCs ameliorate osteoporosis via transporting regenerative signals

Theranostics
Rationale: Mesenchymal stromal cells (MSCs) are considered a promising resource for cell therapy, exhibiting efficacy in ameliorating diverse bone diseases.
Maojiao Li, Q. Tang, Chengcheng Liao, Zhuo Wang, Siyuan Zhang, Qingqing Liang, C. Liang, Xiaodong Liu, Jingyi Zhang, Weidong Tian, Li Liao   +10 more
semanticscholar   +1 more source

CircRNA hsa_circ_0006215 promotes osteogenic differentiation of BMSCs and enhances osteogenesis–angiogenesis coupling by competitively binding to miR-942-5p and regulating RUNX2 and VEGF

Aging, 2021
Coupling between osteogenesis and angiogenesis determines bone morphology. A decrease in the osteogenic ability of bone marrow mesenchymal stem cells (BMSCs) is one of the underlying causes of senile osteoporosis (OP).
Houlin Ji, Xu Cui, Yang Yang, Xiaoxiao Zhou   +3 more
semanticscholar   +1 more source

Propofol nanoparticles promote fracture healing in mice by accelerating cartilage formation

European Cells & Materials
Background: Fracture healing is a process characterized by cartilage formation and subsequent ossification. Propofol, a systemic anesthetic known for its anti-inflammatory and chondrogenic properties, was encapsulated into nanoparticles (NPs) to improve ...
BY Zhang, Z Wang, SJ Yan, H Wang
doaj   +1 more source

BMSCs-derived exosomes inhibit macrophage/microglia pyroptosis by increasing autophagy through the miR-21a-5p/PELI1 axis in spinal cord injury

Aging
Spinal cord injury (SCI) results in a diverse range of disabilities and lacks effective treatment options. In recent years, exosomes derived from bone mesenchymal stem cells (BMSCs) have emerged as a promising cell-free therapeutic approach for treating ...
Jun Gu, Jingyi Wu, Chunming Wang, Zhenwei Xu, Z. Jin, Donghua Yan, Sheng Chen   +6 more
semanticscholar   +1 more source