Results 31 to 40 of about 45,848 (279)

Exosomes Derived From M2 Macrophages Facilitate Osteogenesis and Reduce Adipogenesis of BMSCs

Frontiers in Endocrinology, 2021
Bone regeneration is a complex process that requires the coordination of osteogenesis and osteoclastogenesis. The balance between osteogenesis and adipogenesis of bone marrow mesenchymal stem cells (BMSCs) plays a major role in the process of bone ...
Ziyi Li, Yafei Wang, Shilun Li, Yukun Li
semanticscholar   +1 more source

The protective mechanism of Klotho gene-modified bone marrow mesenchymal stem cells on acute kidney injury induced by rhabdomyolysis

Regenerative Therapy, 2021
Background: Studies have shown that the Klotho gene has tremendous potential for future therapeutic purposes in both acute and chronic kidney diseases (CKD).
WenHui Ni, Ying Zhang, Zhongcheng Yin
doaj   +1 more source

CircHGF suppressed cell proliferation and osteogenic differentiation of BMSCs in ONFH via inhibiting miR-25-3p binding to SMAD7

Molecular Therapy: Nucleic Acids, 2022
Steroid-induced osteonecrosis of the femoral head (ONFH) is a common and devastating bone disorder, which often results in progressive collapse of the femoral head and subsequent osteoarthritis. The proliferation ability and osteogenic differentiation of
Xiaobo Feng, Q. Xiang, J. Jia, Tingting Guo, Zhiwei Liao, Shuhua Yang, Xianyi Cai, Xianzhe Liu   +7 more
semanticscholar   +1 more source

Bone mesenchymal stem cells (BMSCs)-derived exosomal microRNA-21-5p regulates Kruppel-like factor 3 (KLF3) to promote osteoblast proliferation in vitro

Bioengineered, 2022
Bone mesenchymal stem cells (BMSCs)-derived exosomes (Exos) play important roles in osteoporosis, while the regulation of microRNA (miR)-21-5p remains unclear.
Murong You, Zisheng Ai, Jihuan Zeng, Yang Fu, Liang Zhang, Xin Wu   +5 more
semanticscholar   +1 more source

Biocompatible reduced graphene oxide stimulated BMSCs induce acceleration of bone remodeling and orthodontic tooth movement through promotion on osteoclastogenesis and angiogenesis

Bioactive Materials, 2022
We has synthesized the biocompatible gelatin reduced graphene oxide (GOG) in previous research, and in this study we would further evaluate its effects on bone remodeling in the aspects of osteoclastogenesis and angiogenesis so as to verify its impact on
Delong Jiao, Jing Wang, Wenting Yu, Ke Zhang, Ning Zhang, Lingyan Cao, Xinquan Jiang, Yuxing Bai   +7 more
semanticscholar   +1 more source

Mitochondria on the move: BMSCs fuel AML energy [PDF]

Blood, 2017
In this issue of Blood, Marlein et al1 identify a tumor-specific NOX2-dependent transfer of mitochondria from bone marrow stromal cells (BMSCs) to acute myeloid leukemia (AML) cells via AML-derived tunneling nanotubes (see figure), supporting inhibition of NOX2 as a novel therapeutic strategy in AML.
openaire   +2 more sources

Osterix Enhances BMSC-associated Osseointegration of Implants

Journal of Dental Research, 2009
Cellular and molecular events in osseointegration at the dental implant surface remain largely unknown. We hypothesized that bone marrow stromal cells (BMSCs) participate in this process, and that osterix (Osx) promotes implant osseointegration. To prove this hypothesis, we tracked double-labeled BMSCs in implantation sites created in nude mice ...
B, Xu, J, Zhang, E, Brewer, Q, Tu, L, Yu, J, Tang, P, Krebsbach, M, Wieland, J, Chen   +8 more
openaire   +3 more sources

Serum exosomes from young rats improve the reduced osteogenic differentiation of BMSCs in aged rats with osteoporosis after fatigue loading in vivo

Stem cell research & therapeutics, 2021
Osteoporosis is a major public health concern for the elderly population and is characterized by fatigue load resulting in bone microdamage. The ability of bone mesenchymal stem cells (BMSCs) to repair bone microdamage diminishes with age, and the ...
Jingqiong Xun, Chan Li, Meichun Liu, Yueming Mei, Qiongfei Zhou, Bo Wu, Fen Xie, Yuling Liu, R. Dai   +8 more
semanticscholar   +1 more source

Cyclooxygenase-2 negatively regulates osteogenic differentiation in murine bone marrow mesenchymal stem cells via the FOXO3a/p27kip1 pathway

Bone & Joint Research
Aims: Cyclooxygenase-2 (COX-2) is an enzyme that synthesizes prostaglandins from arachidonic acid. Previous reports have indicated that COX-2 is constitutively expressed in osteogenic cells instead of being expressed only after pathogenic induction, and
Shu-Chun Chuang, Ya-Shuan Chou, Yi-Shan Lin, Je-Ken Chang, Chung-Hwan Chen, Mei-Ling Ho   +5 more
doaj   +1 more source

Bone mesenchymal stem cells contributed to the neointimal formation after arterial injury. [PDF]

PLoS ONE, 2013
OBJECTIVES: Recent findings suggest that in response to repair-to-injury bone marrow mesenchymal stem cells (BMSCs) participate in the process of angiogenesis. It is unclear what role BMSCs play in the structure of the vessel wall.
Mincai Li, Suqin Li, Liangzhu Yu, Jiliang Wu, Tonghui She, Yaping Gan, Zhenwu Hu, Wenli Liao, Hongli Xia   +8 more
doaj   +1 more source