Results 11 to 20 of about 45,848 (279)
Advanced Healthcare Materials, 2023 Periodontitis is a prevalent dental disease marked by progressive destruction of tooth‐supporting tissues, and the recovery of bone defects after periodontitis remains challenging. Although stem cell‐based therapy is a promising treatment for periodontal
Jiaxin Luo +7 more
semanticscholar +1 more source
Effects of BMSC-Derived EVs on Bone Metabolism
Pharmaceutics, 2022 Extracellular vesicles (EVs) are small membrane vesicles that can be secreted by most cells. EVs can be released into the extracellular environment through exocytosis, transporting endogenous cargo (proteins, lipids, RNAs, etc.) to target cells and thereby triggering the release of these biomolecules and participating in various physiological and ...
Xuchang Zhou +4 more
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Sirt3-mediated mitophagy regulates AGEs-induced BMSCs senescence and senile osteoporosis
Redox Biology, 2021 Senile osteoporosis (SOP) is widely regarded as one of the typical aging-related diseases due to a decrease in bone mass and the destruction in microarchitecture.
Yuanyuan Guo +8 more
semanticscholar +1 more source
Biofabrication, 2023 Although autologous bone (AB) grafting is considered to be the gold standard for cranioplasty, unresolved problems remain, such as surgical-site infections and bone flap absorption. In this study, an AB scaffold was constructed via three-dimensional (3D)
Yu Huan +13 more
semanticscholar +1 more source
Efficiency of Cell Therapy to GC-Induced ONFH: BMSCs with Dkk-1 Interference Is Not Superior to Unmodified BMSCs [PDF]
Stem Cells International, 2018 Glucocorticoid-induced osteonecrosis of the femoral head (ONFH) is a hip disorder, and it threatens patients who require megadose of steroid therapies. Nowadays, no valid therapies can reverse the development of GC-induced ONFH once it occurs. Stem cell therapy to GC-induced ONFH would be a promising choice. Although the pathogenesis of GC-induced ONFH
Wei Zhun +4 more
openaire +3 more sources
Bone & Joint Research, 2023 Aims: Osteoporosis is characterized by decreased trabecular bone volume, and microarchitectural deterioration in the medullary cavity. Interleukin-19 (IL-19), a member of the IL-10 family, is an anti-inflammatory cytokine produced primarily by ...
Zhicheng Dai +7 more
doaj +1 more source
Reactive oxygen species mediate TNF-α-induced inflammatory response in bone marrow mesenchymal cells [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): It is generally believed that the inflammatory response in bone marrow mesenchymal stem cells (BMSCs) transplantation leads to poor survival and unsatisfactory effects, and is mainly mediated by cytokines, including interleukin-1β (IL-1β ...
Liuzhong Wu, Yaping Pan
doaj +1 more source
Archives of Medical Science, 2022 Introduction In this study, we aimed to investigate the role of miRNA-21 and the regulating pathway that promotes the differentiation of bone marrow mesenchymal stem cells (BMSCs). Material and methods We used miR-21-OE, miR-21-KD, ajuba-OE and ajuba-KD
Wengang Yang +4 more
doaj +1 more source
In-situ forming injectable GFOGER-conjugated BMSCs-laden hydrogels for osteochondral regeneration
npj Regenerative Medicine, 2023 The collagen-mimetic peptide GFOGER possesses the chondrogenic potential and has been used as a cell adhesion peptide or chondrogenic inducer. Here, we prepared an injectable in situ forming composite hydrogel system comprising methoxy polyethylene ...
M. Ha +4 more
semanticscholar +1 more source
Cell Death and Differentiation, 2021 Aged bone marrow mesenchymal stem cells (BMSCs) exhibit aberrant self-renewal and lineage specification, which contribute to imbalanced bone-fat and progressive bone loss.
Hengguo Zhang +12 more
semanticscholar +1 more source