Autoimmunity, 2021 Although long non-coding RNA LINC00963 has been reported to play a crucial regulatory role in osteoporosis (OP), its specific mechanism has not been well studied.
Limin Guo, Lirong Ren
exaly +2 more sources
TMT-Based Proteomic Explores the Influence of DHEA on the Osteogenic Differentiation of hBMSCs [PDF]
Frontiers in Cell and Developmental Biology, 2021 Dehydroepiandrosterone (DHEA) has been revealed to implicate in facilitating osteoblast differentiation of human bone marrow mesenchymal stem cells (hBMSCs) and inhibiting osteoporosis (OP). However, the underlying molecular mechanism remains largely unknown.
Xiaonan Liang, Xixi He, Wei Qingjun
exaly +4 more sources
Multi-omics identification of key targets for the osteogenic differentiation of human bone marrow mesenchymal stromal cells under oxidative stress [PDF]
Scientific ReportsHuman bone marrow mesenchymal stromal cells (hBMSCs) are multipotent stromal cells capable of osteogenic differentiation, making them a promising cell source for bone tissue engineering and regenerative medicine.
Wentao Dong +11 more
doaj +2 more sources
Hypoxia-preconditioning human bone marrow-derived mesenchymal stem cells induce high-quality mitochondrial transfer through gap junctions to alleviate ischemia-reperfusion injury in liver graft [PDF]
Cell Communication and SignalingBackground Amid the widespread scarcity of donor livers, mitigating ischemia-reperfusion injury (IRI) of liver grafts is vital for ensuring early recovery of post-transplant liver function.
Xinling Luo +8 more
doaj +2 more sources
Decellularized Disc Hydrogels for hBMSCs tissue-specific differentiation and tissue regeneration
Bioactive Materials, 2021 Tissue specificity, a key factor in the decellularized tissue matrix (DTM), has shown bioactive functionalities in tuning cell fate-e.g., the differentiation of mesenchymal stem cells. Notably, cell fate is also determined by the living microenvironment, including material composition and spatial characteristics.
Xiangcheng Qing, Shuo Tian, Xiao Lv
exaly +4 more sources
piR-27222 alleviates dexamethasone-induced osteoporosis by inhibiting ferroptosis through modulating WWP1 [PDF]
Journal of Orthopaedic Surgery and ResearchBackground Glucocorticoid-induced osteoporosis (GIOP) is the most common cause of secondary osteoporosis. Piwi-interacting RNA (piRNA) represents a novel class of small non-coding RNAs.
Yusen Dai +3 more
doaj +2 more sources
Nanotopography-Mediated Mechanotransduction Enhances hBMSCs Adhesion on TiO<sub>2</sub> Nanotubes. [PDF]
J Funct BiomaterTitanium and its alloys are widely used for orthopedic implants, but their intrinsic bioinertness may hinder osseointegration. In this study, titanium dioxide nanotube (TNT) arrays were fabricated on Ti-6Al-4V scaffolds via anodization, and their effects on the adhesion behavior of human bone marrow mesenchymal stem cells (hBMSCs) were investigated ...
Xiong C +9 more
europepmc +2 more sources
Identification and Validation of a New Functional Gene <i>TSC22D3</i> for hBMSCs Osteogenesis. [PDF]
Stem Cells IntBackground Osteogenic differentiation is a crucial process in which bone marrow mesenchymal stem cells (BMSCs) differentiate into osteoblasts, involving the regulation of multiple genes and signaling pathways.
Zhang S +7 more
europepmc +3 more sources
Effect of monocytes/macrophages on the early osteogenic differentiation of hBMSCs
Journal of Tissue Engineering and Regenerative Medicine, 2013 Heterotypic cell interactions are essential for the homeostasis of bone tissue, in particular the widely studied interaction between osteoblasts and osteoclasts. Closely related with osteoclasts are monocytes/macrophages. These have been shown to produce osteogenic factors, e.g. BMP-2, which plays a key role in bone metabolism.
R P Pirraco, Ap Marques, Rui L Reis
exaly +3 more sources
lncRNA NEAT1 regulates CYP1A2 and influences steroid-induced necrosis
Open Life Sciences, 2021 The main cause of steroid-induced necrosis of femoral head (SNFH) is excessive glucocorticoid (GC) intake. The aim of this article was to investigate the role of lncRNA NEAT1 as a molecular sponge to adsorb miR-23b-3p and regulate CYP1A2 in SNFH ...
Zhou Yongfang +6 more
doaj +1 more source