Results 1 to 10 of about 6,219 (219)

Osteogenic induction of hBMSCs by electrospun scaffolds with dexamethasone release functionality [PDF]

Biomaterials, 2010
Electrospun structures were proposed as scaffolds owing to their morphological and structural similarities with the extracellular matrix found in many native tissues.
Albino Martins, Ana Rita Cruz Duarte, Rui L Reis   +2 more
exaly   +6 more sources

LncRNA LINC00963 promotes osteogenic differentiation of hBMSCs and alleviates osteoporosis progression by targeting miRNA-760/ETS1 axis

Autoimmunity, 2021
Although long non-coding RNA LINC00963 has been reported to play a crucial regulatory role in osteoporosis (OP), its specific mechanism has not been well studied.
Lirong Ren, Limin Guo, Nannan Kou, Jia Lv, Zhihua Wang, Kaishun Yang   +5 more
exaly   +2 more sources

Multi-omics identification of key targets for the osteogenic differentiation of human bone marrow mesenchymal stromal cells under oxidative stress [PDF]

Scientific Reports
Human bone marrow mesenchymal stromal cells (hBMSCs) are multipotent stromal cells capable of osteogenic differentiation, making them a promising cell source for bone tissue engineering and regenerative medicine.
Wentao Dong, Yangyang Zheng, Yongfang Zhou, Tao Wang, Jiexin Yang, Huaying Li, Fanchao Li, Chuan Wang, Liang Liang, Hao Li, Jian Zhang, Wuxun Peng   +11 more
doaj   +2 more sources

Hypoxia-preconditioning human bone marrow-derived mesenchymal stem cells induce high-quality mitochondrial transfer through gap junctions to alleviate ischemia-reperfusion injury in liver graft [PDF]

Cell Communication and Signaling
Background Amid the widespread scarcity of donor livers, mitigating ischemia-reperfusion injury (IRI) of liver grafts is vital for ensuring early recovery of post-transplant liver function.
Xinling Luo, Weiqi Zeng, Erfeng Xiong, Ziming Wang, Jingsheng Huang, Meiqi Luo, Zhongxian He, Jinyu Liu, Dongdong Yuan   +8 more
doaj   +2 more sources

LINC00662 regulates osteogenic differentiation of BMSCs and inhibits fracture healing via miR-330-3p/PTEN axis [PDF]

BMC Musculoskeletal Disorders
Background Surgical treatment alone is not effective in addressing delayed fracture healing (DFH). This study nvestigates the molecular mechanism underlying fracture healing to identify improved therapeutic strategies.
Jiawei Gong, Jiehua Luo, Teng Zeng, Liping Zhu, Huasong Luo, Kun Ding, Mohamed Lamin Bangura, Jinliang Ma, Yunfeng Lv   +8 more
doaj   +2 more sources

lncRNA NEAT1 regulates CYP1A2 and influences steroid-induced necrosis

Open Life Sciences, 2021
The main cause of steroid-induced necrosis of femoral head (SNFH) is excessive glucocorticoid (GC) intake. The aim of this article was to investigate the role of lncRNA NEAT1 as a molecular sponge to adsorb miR-23b-3p and regulate CYP1A2 in SNFH ...
Zhou Yongfang, Zhang Fei, Xu Fengyang, Wang Qiang, Wu Jianhua, Peng Wuxun, Dong Wentao   +6 more
doaj   +1 more source

Alkali-treated titanium dioxide promotes formation of proteoglycan layer and altered calcification and immunotolerance capacity in bone marrow stem cell

Biochemistry and Biophysics Reports, 2023
Introduction: In this study, we report that a proteoglycans (PGs)-layer between the bone and titanium dioxide (TiO2) surface after osseointegration improved the calcification capacity and immunotolerance of human bone marrow mesenchymal stem cells ...
Tomomi Mizutani, Shuhei Tsuchiya, Masaki Honda, Jorge Luis Montenegro Raudales, Kensuke Kuroda, Hironori Miyamoto, Tomohisa Nakamura, Kenichiro Ishibashi, Yasuyuki Shibuya   +8 more
doaj   +1 more source

SOX9 Inhibits the Progression of Osteonecrosis of the Femoral Head via the Activation of the Wnt/Beta-Catenin Pathway

Journal of Investigative Surgery, 2023
Background: In this study, we aimed to explore whether the SRY-box transcription factor 9 (SOX9) can play protective roles against the occurrence and development of osteonecrosis of the femoral head (ONFH) by regulating the proliferation, apoptosis, and ...
Xiangsheng Meng, Haiquan Zhu
doaj   +1 more source

Ubiquitin-specific protease 53 promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells

Cell Death and Disease, 2021
The ubiquitin protease pathway plays important role in human bone marrow-derived mesenchymal stem cell (hBMSC) differentiation, including osteogenesis.
Dawoon Baek, Kwang Hwan Park, Kyoung-Mi Lee, Sujin Jung, Soyeong Joung, Jihyun Kim, Jin Woo Lee   +6 more
doaj   +1 more source

Characterization of Human, Ovine and Porcine Mesenchymal Stem Cells from Bone Marrow: Critical In Vitro Comparison with Regard to Humans

Life, 2023
For research and clinical use of stem cells, a suitable animal model is necessary. Hence, the aim of this study was to compare human-bone-marrow-derived mesenchymal stem cells (hBMSCs) with those from sheep (oBMSCs) and pigs (pBMSCs).
Elisa Katja Westerkowsky, Adriana Marisa Soares de Almeida, Michael Selle, Oliver Harms, Katrin Bundkirchen, Claudia Neunaber, Sandra Noack   +6 more
doaj   +1 more source