Autoimmunity, 2021 Although long non-coding RNA LINC00963 has been reported to play a crucial regulatory role in osteoporosis (OP), its specific mechanism has not been well studied.
Lirong Ren +5 more
exaly +3 more sources
Engineering Spatially Localized Bioactive Microenvironments in Assembly Implants for Spatially Extended Bone Ingrowth. [PDF]
Adv Sci (Weinh)An assembly porous titanium/β‐TCP implant is developed to establish a spatially programmable osteogenic microenvironment for enhanced osseointegration. By decoupling mechanical support from bioactive ion release, localized ionic gradients generated from the β‐TCP module direct osteogenic activity and bone ingrowth toward the porous titanium framework ...
Zhang H +5 more
europepmc +2 more sources
Multi-omics identification of key targets for the osteogenic differentiation of human bone marrow mesenchymal stromal cells under oxidative stress [PDF]
Scientific ReportsHuman bone marrow mesenchymal stromal cells (hBMSCs) are multipotent stromal cells capable of osteogenic differentiation, making them a promising cell source for bone tissue engineering and regenerative medicine.
Wentao Dong +11 more
doaj +2 more sources
m<sup>6</sup>A-modified DRAM1 recognized by YTHDF1 regulates autophagy during dexamethasone-induced osteogenic inhibition. [PDF]
Clin Transl MedDRAM1 plays a critical role in the modulation of autophagy. The m6A methylation level of DRAM1 mRNA is suppressed by dexamethasone. Dexamethasone impairs autophagy‐associated osteogenic differentiation by inhibiting YTHDF1‐mediated translation of m6A‐modified DRAM1.
Lu ZY +14 more
europepmc +2 more sources
Engineered Nature-Based Sonosensitizer for Broad-Spectrum Infectious Tissue Repair via Sono-Ionic Therapy. [PDF]
Exploration (Beijing)A schematic illustration of an engineered nature‐based sonosensitizer enables early‐stage high‐power ultrasound to generate substantial reactive oxygen species for antibacterial effects and late‐stage low‐power sono‐ionic therapy for infected bone repair, infected wound biofilm therapy, and wound regeneration.
Ma L +13 more
europepmc +2 more sources
Hypoxia-preconditioning human bone marrow-derived mesenchymal stem cells induce high-quality mitochondrial transfer through gap junctions to alleviate ischemia-reperfusion injury in liver graft [PDF]
Cell Communication and SignalingBackground Amid the widespread scarcity of donor livers, mitigating ischemia-reperfusion injury (IRI) of liver grafts is vital for ensuring early recovery of post-transplant liver function.
Xinling Luo +8 more
doaj +2 more sources
piR-27222 alleviates dexamethasone-induced osteoporosis by inhibiting ferroptosis through modulating WWP1 [PDF]
Journal of Orthopaedic Surgery and ResearchBackground Glucocorticoid-induced osteoporosis (GIOP) is the most common cause of secondary osteoporosis. Piwi-interacting RNA (piRNA) represents a novel class of small non-coding RNAs.
Yusen Dai +3 more
doaj +2 more sources
lncRNA NEAT1 regulates CYP1A2 and influences steroid-induced necrosis
Open Life Sciences, 2021 The main cause of steroid-induced necrosis of femoral head (SNFH) is excessive glucocorticoid (GC) intake. The aim of this article was to investigate the role of lncRNA NEAT1 as a molecular sponge to adsorb miR-23b-3p and regulate CYP1A2 in SNFH ...
Zhou Yongfang +6 more
doaj +1 more source
Biochemistry and Biophysics Reports, 2023 Introduction: In this study, we report that a proteoglycans (PGs)-layer between the bone and titanium dioxide (TiO2) surface after osseointegration improved the calcification capacity and immunotolerance of human bone marrow mesenchymal stem cells ...
Tomomi Mizutani +8 more
doaj +1 more source
Journal of Investigative Surgery, 2023 Background: In this study, we aimed to explore whether the SRY-box transcription factor 9 (SOX9) can play protective roles against the occurrence and development of osteonecrosis of the femoral head (ONFH) by regulating the proliferation, apoptosis, and ...
Xiangsheng Meng, Haiquan Zhu
doaj +1 more source