Results 11 to 20 of about 6,219 (219)

Effect of monocytes/macrophages on the early osteogenic differentiation of hBMSCs [PDF]

Journal of Tissue Engineering and Regenerative Medicine, 2012
Heterotypic cell interactions are essential for the homeostasis of bone tissue, in particular the widely studied interaction between osteoblasts and osteoclasts. Closely related with osteoclasts are monocytes/macrophages. These have been shown to produce
Adams, Aggarwal, Bennett, Bessa, Champagne, Chang, Dimitriou, Dominici, Einhorn, Francesca, Frank, Fromigué, Fujikawa, Gori, Haynes, Hume, Jiang, Kreutz, Lecanda, Lian, Linkhart, Lou, Maniatopoulos, Mikami, Mundy, Nishimura, O'Brien, Parfitt, Phillips, Pirraco, Quinn, Raggatt, Rodan, Ryan, Sasaki, Schmitt, Schmitt, Stein, Takahashi, Teitelbaum, Teitelbaum, Tintut, Udagawa, Valentin-Opran, Yuan, Zannettino   +45 more
core   +2 more sources

A Novel Long Noncoding RNA-LNC000133 Associated With Steroid-Induced Osteonecrosis of the Femoral Head Promotes Osteoblast Differentiation Through Bone Marrow Mesenchymal Stem Cells-Derived Exosomes Pathway: A Bioinformatics Validation and Detailed Mechanistic Study. [PDF]

J Cell Mol Med
ABSTRACT Steroid‐induced osteonecrosis of the femoral head (SONFH) is a debilitating disease caused by glucocorticoid abuse, characterized by complex pathogenesis and unclear molecular mechanisms. Dysfunction of bone marrow mesenchymal stem cells (BMSCs) and their exosome‐mediated signalling is a key contributor to SONFH, although the precise ...
Yang C, Xia T, Li X, Chen T, Xu Y.
europepmc   +2 more sources

Repurposing Hetrombopag for Multiple Myeloma by Targeting PNPO: A Celastrol-Inspired Approach. [PDF]

Basic Clin Pharmacol Toxicol
Hetrombopag targeted PNPO to inhibit multiple myeloma. ABSTRACT Multiple myeloma (MM) is a malignancy of plasma cells whose excessive immunoglobulin production elevates reactive oxygen species (ROS), promoting pathogenesis. Active compounds from Traditional Chinese Medicine, such as celastrol, can exert antitumour effects by further increasing ROS ...
Yu T, Wang C, Xie J, Wei Y, Cui H, Zhang H, Zhou F, Deng Z, Yang Y, Gu C.   +9 more
europepmc   +2 more sources

Cell Membrane Vesicles Derived from Hbmscs and Huvecs Enhance Bone Regeneration

Bone Research, 2023
Abstract Bone tissue renewal can be enhanced through co-transplantation of bone mesenchymal stem cells (BMSCs) and vascular endothelial cells (ECs). However, there are apparent limitations in stem cell-based therapy which hinder its clinic translation.
Dandan Wang, Yaru Guo, Boon Chin Heng, Xuehui Zhang, Yan Wei, Ying He, Mingming Xu, Bin Xia, Xuliang Deng   +8 more
openaire   +3 more sources

A LDH-Based Supramolecular Photosensitizer-Functionalized Bioactive Glass Scaffold for Integrated Postoperative Osteosarcoma Recurrence Prevention and Bone Regeneration. [PDF]

Adv Sci (Weinh)
An intercalation assembly strategy is proposed to construct a novel LDH‐based supramolecular photosensitizer, which exhibits outstanding reactive oxygen species generation activity under 1270 nm laser irradiation. The deposition of supramolecular photosensitizer onto the surface of bioactive glass scaffolds results in the development of an innovative ...
Wang T, Bian Y, Hu T, Li M, Tan Y, Yang Y, Jian X, Weng X, Tan C, Liang R.   +9 more
europepmc   +2 more sources

Genetically modified human bone marrow derived mesenchymal stem cells for improving the outcome of human islet transplantation. [PDF]

PLoS ONE, 2013
The objective of this study was to determine the potential of human bone marrow derived mesenchymal stem cells (hBMSCs) as gene carriers for improving the outcome of human islet transplantation.
Vaibhav Mundra, Hao Wu, Ram I Mahato
doaj   +1 more source

DLL4 restores damaged liver by enhancing hBMSC differentiation into cholangiocytes

Stem Cell Research, 2020
Biliary injury is one of the main pathological mechanisms of fulminant hepatic failure (FHF). Delta-like ligand 4 (DLL4)-mediated Notch activation contributes to reversing biliary injury; however, the specific role of DLL4 in biliary restoration is still unclear.
Suwan Sun, Lunzhi Yuan, Zhanglu An, Dongyan Shi, Jiaojiao Xin, Jing Jiang, Keke Ren, Jiaxian Chen, Beibei Guo, Xingping Zhou, Qian Zhou, Xiaojun Jin, Sihan Ruan, Tong Cheng, Ningshao Xia, Jun Li   +15 more
openaire   +3 more sources

A comparative study of HAMSCs/HBMSCs transwell and mixed coculture systems [PDF]

IUBMB Life, 2019
AbstractOur previous studies indicated that a coculture system containing human amnion‐derived mesenchymal stem cells (HAMSCs) and human bone marrow mesenchymal stem cells (HBMSCs) has the potential of application for bone regeneration. However, there is currently no enough comparative investigation between HAMSCs/HBMSCs transwell and mixed coculture ...
Yifeng Bian, Yifei Du, Ruixia Wang, Ning Chen, Xin Du, Yuli Wang, Hua Yuan   +6 more
openaire   +2 more sources

Comparison of chondrogenesis-related biological behaviors between human urine-derived stem cells and human bone marrow mesenchymal stem cells from the same individual

Stem Cell Research & Therapy, 2021
Background Stem cells are the main choice for seed cells in tissue engineering, but using most traditional stem cells requires invasive and complicated procedures.
Jiachen Sun, Fei Xing, Min Zou, Min Gong, Lang Li, Zhou Xiang   +5 more
doaj   +1 more source

Enhanced Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells by a Hybrid Hydroxylapatite/Collagen Scaffold

Frontiers in Cell and Developmental Biology, 2021
Human bone marrow-derived mesenchymal stem cells (hBMSCs) and their derivative enhanced green fluorescent protein (eGFP)-hBMSCs were employed to evaluate an innovative hybrid scaffold composed of granular hydroxylapatite and collagen hemostat (Coll/HA ...
Elisa Mazzoni, Chiara Mazziotta, Maria Rosa Iaquinta, Carmen Lanzillotti, Francesca Fortini, Antonio D’Agostino, Lorenzo Trevisiol, Riccardo Nocini, Giovanni Barbanti-Brodano, Andrea Mescola, Andrea Alessandrini, Andrea Alessandrini, Mauro Tognon, Fernanda Martini   +13 more
doaj   +1 more source