Results 41 to 50 of about 3,978 (176)

Effects of miR-103 by negatively regulating SATB2 on proliferation and osteogenic differentiation of human bone marrow mesenchymal stem cells.

PLoS ONE, 2020
BACKGROUND:The proliferation and osteogenic differentiation of human bone marrow mesenchymal stem cells (HBMScs) are modulated by a variety of microRNAs (miRNAs). SATB homeobox 2 (SATB2) is a critical transcription factor that contributes to maintain the
Hao Lv, Huashan Yang, Yuanrui Wang
doaj   +1 more source

Long noncoding RNA KCNMA1-AS1 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells by activating the SMAD9 signaling pathway

Biology Direct, 2023
The human bone marrow mesenchymal stem cells (hBMSCs) undergo intense osteogenic differentiation, a crucial bone formation mechanism. Evidence from prior studies suggested an association between long noncoding RNAs (lncRNAs) and the osteogenic ...
Zhaoyi Mai, Jingpeng Liu, Xiao Jiang, Wenli Gu, Wei Wang, Simin Li, Gerhard Schmalz, Hui Xiao, Jianjiang Zhao   +8 more
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Micro-/nano-structured zirconia surface promotes osteogenic differentiation of human bone marrow mesenchymal stem cells by reducing pyroptosis under inflammatory conditions

Journal of Dental Sciences
Background/purpose: Promoting osteogenesis under inflammatory conditions holds promise for preventing and mitigating peri-implantitis. Cell pyroptosis inhibits osteoblast-mediated bone formation.
Hui-Min Wang, Qian Ding, Ying Chen, Yao-Jun Zhang, Zhi-Xiao Wu, Xiao Zhang, Lei Zhang   +6 more
doaj   +1 more source

Bone marrow mesenchymal stem cells transplantation promotes the release of endogenous erythropoietin after ischemic stroke

Neural Regeneration Research, 2015
This study investigated whether bone marrow mesenchymal stem cell (BMSC) transplantation protected ischemic cerebral injury by stimulating endogenous erythropoietin.
Wen Lv, Wen-yu Li, Xiao-yan Xu, Hong Jiang, Oh Yong Bang   +4 more
doaj   +1 more source

Identification of a clinical signature predictive of differentiation fate of human bone marrow stromal cells

Stem Cell Research & Therapy, 2021
Background Transplantation of human bone marrow stromal cells (hBMSCs) is a promising therapy for bone regeneration due to their ability to differentiate into bone forming osteoblastic cells.
Justyna Magdalena Kowal, Sören Möller, Dalia Ali, Florence Figeac, Torben Barington, Hagen Schmal, Moustapha Kassem   +6 more
doaj   +1 more source

Engineered Nature‐Based Sonosensitizer for Broad‐Spectrum Infectious Tissue Repair via Sono‐Ionic Therapy

Exploration, EarlyView.
A schematic illustration of an engineered nature‐based sonosensitizer enables early‐stage high‐power ultrasound to generate substantial reactive oxygen species for antibacterial effects and late‐stage low‐power sono‐ionic therapy for infected bone repair, infected wound biofilm therapy, and wound regeneration.
Liang Ma, Hongchuan Wang, Weidong Liang, Tao Xu, Jie Lei, Li Zhang, Shutao Gao, Xiaoyu Cai, Qian Li, Wenzhao Wang, Chuanhui Xun, Weibin Sheng, Cao Yang, Yingsong Wang   +13 more
wiley   +1 more source

Retracted: Overexpression of RPN2 promotes osteogenic differentiation of hBMSCs through the JAK/STAT3 pathway [PDF]

FEBS Open Bio, 2019
Osteoporosis is characterized by decreased bone mass and degenerating bone structure, which cause severe bone fragility and increase the risk for fractures. Human bone mesenchymal stem cells (hBMSCs) differentiate into osteoblasts through osteogenesis, and disturbances in the balance between bone generation and degeneration underlie the pathogenesis of
Ling Ni, Jianhua Yu, Xueqiong Gui, Zhonghua Lu, Xiwen Wang, Hongyan Guo, Ying Zhou   +6 more
openaire   +3 more sources

Progress in bone tissue engineering biomaterials: Development, challenges, and prospects

VIEW, EarlyView.
Scheme 1 Application of biomaterials in immunomodulation during bone tissue engineering. Abstract Bone defect repair remains a major clinical challenge in orthopedics. Over 2 million cases caused by trauma, tumors, and other factors occur annually, with large‐scale defects posing a particular bottleneck due to limited self‐healing capacity.
Yuanbin Zhang, Junlei Chai, Quanwei Ding, Luping Liu, Kejie Zhang, Jie Lin, Jianhua Zhang, Youju Huang   +7 more
wiley   +1 more source

[Retracted] TRPM7 Upregulate the Activity of SMAD1 through PLC Signaling Way to Promote Osteogenesis of hBMSCs [PDF]

BioMed Research International, 2020
TRPM7 is a member of the transient receptor potential cation channel (TRP channel) subfamily M and possesses both an ion channel domain and a functional serine/threonine α‐kinase domain. It has been proven to play an essential role in the osteogenic differentiation of human bone marrow‐derived mesenchymal stem cells (hBMSCs).
Fanfan Hong, Shali Wu, Cui Zhang, Liang Li, Jianling Chen, Yong Fu, Jinfu Wang   +6 more
openaire   +2 more sources