Results 51 to 60 of about 3,978 (176)

LINC00473 regulated apoptosis, proliferation and migration but could not reverse cell cycle arrest of human bone marrow mesenchymal stem cells induced by a high-dosage of dexamethasone

open access: yesStem Cell Research, 2020
Dysfunction of bone marrow mesenchymal stem cells (BMSCs) is involved in the pathogenesis of steroid-induced osteonecrosis of the femoral head (SONFH).
Yingxing Xu   +6 more
doaj   +1 more source

YTHDF3 Enhances Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoporosis by Promoting TBX19 Expression

open access: yesCell Proliferation, EarlyView.
In this study, OP‐BMSCs were successfully isolated from OVX osteoporotic rats. Mechanistic investigations revealed that the RNA‐binding protein YTHDF3 significantly upregulates Tbx19 expression by enhancing the stability of Tbx19 mRNA. Elevated Tbx19 levels, in turn, activate key osteogenic molecules, effectively promoting the differentiation of OP ...
Qianke Tao   +9 more
wiley   +1 more source

MWCNTs enhance hBMSCs spreading but delay their proliferation in the direction of differentiation acceleration [PDF]

open access: yesCell Adhesion & Migration, 2014
Investigating the ability of films of pristine multiwalled nanotubes (MWCNTs) to influence human mesenchymal stem cells' proliferation, morphology, and differentiation into osteoblasts, we concluded to the following: A. MWCNTs delay the proliferation of hBMS cells but increase their differentiation.
openaire   +2 more sources

Chordin-Like 1 Improves Osteogenesis of Bone Marrow Mesenchymal Stem Cells Through Enhancing BMP4-SMAD Pathway

open access: yesFrontiers in Endocrinology, 2019
Chordin-like 1 (CHRDL1) is a secreted glycoprotein with repeated cysteine-rich domains, which can bind to BMPs family ligands. Although it has been reported to play important roles in several systems, the exact roles of CHRDL1 on human bone mesenchymal ...
Tao Liu   +9 more
doaj   +1 more source

Priming with interleukin‐1α and chemical hypoxia modulates the mesenchymal stem cell secretome to dampen microglial inflammation and promote neuroprotection

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 17, Page 5355-5371, September 2026.
Abstract Background and Purpose We hypothesised that dual priming of human bone marrow‐derived human mesenchymal stem cells (hBMSCs) with interleukin‐1alpha (IL‐1α) and CoCl2 (a hypoxia mimetic) would modulate their therapeutic efficacy for hypoxic‐ischaemic conditions. Experimental Approach hBMSCs were primed individually or in combination.
Maryam Adenike Salaudeen   +2 more
wiley   +1 more source

Evaluation of Boron/Strontium Co‐Substituted‐Hydroxyapatite Incorporated Collagen Composite Scaffolds: Physicochemical, Thermal, Mechanical, Biological, and Sustained‐Release Investigations

open access: yesMacromolecular Materials and Engineering, Volume 311, Issue 8, August 2026.
A collagen‐based composite scaffold containing boron/strontium co‐substituted hydroxyapatite is developed to enhance the bioactivity of collagen through the incorporation of bioactive ions. This composite exhibits good stability and improved mechanical properties compared to collagen.
Hamideh Karimi   +4 more
wiley   +1 more source

LncRNA USP2-AS1 facilitates the osteogenic differentiation of bone marrow mesenchymal stem cells by targeting KDM3A/ETS1/USP2 to activate the Wnt/β-catenin signaling pathway

open access: yesRNA Biology
Human bone marrow mesenchymal stem cells (HBMSCs) can promote new bone formation. Previous studies have proven the ability of long non-coding RNAs (lncRNAs) to modulate the osteogenic differentiation of mesenchymal stem cells.
Wanxin Luo   +6 more
doaj   +1 more source

Aqueous Two‐Phase Bioinks for Discrete Packing and Compartmentalization of 3D Bioprinted Cells

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 25, 3 July 2026.
Aqueous two‐phase systems (ATPS) enable the formation of biomimetic interfaces crucial for tissue engineering. However, clinical translation remains limited by the challenge of precisely controlling cellular compartmentalization. Here, we developed ATPS biomaterial inks for 3D bioprinting allowing tuneable droplet formation via NaCl modulation.
Martina Marcotulli   +17 more
wiley   +1 more source

Dynamic Tracking Human Mesenchymal Stem Cells Tropism following Smoke Inhalation Injury in NOD/SCID Mice

open access: yesStem Cells International, 2016
Multiple preclinical evidences have supported the potential value of mesenchymal stem cells (MSCs) for treatment of acute lung injury (ALI). However, few studies focus on the dynamic tropism of MSCs in animals with acute lung injury.
MeiJuan Song   +14 more
doaj   +1 more source

Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 27, 17 July 2026.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez   +6 more
wiley   +1 more source

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