Results 61 to 70 of about 6,219 (219)

Silencing HIF-1α reduces the adhesion and secretion functions of acute leukemia hBMSCs [PDF]

Brazilian Journal of Medical and Biological Research, 2012
Hypoxia inducible factor-1α (HIF-1α) is an important transcription factor, which plays a critical role in the formation of solid tumor and its microenvironment. The objective of the present study was to evaluate the expression and function of HIF-1α in human leukemia bone marrow stromal cells (BMSCs) and to identify the downstream targets of HIF-1α ...
Dong-Feng, Zeng, Ting, Liu, Cheng, Chang, Xi, Zhang, Xue, Liang, Xing-Hua, Chen, Pei-Yan, Kong   +6 more
openaire   +5 more sources

Engineering Extracellular Vesicle Production Through Magnetic Ion Channel Activation for Bone Regeneration

Advanced Healthcare Materials, EarlyView.
Magnetic Ion Channel Activation (MICA) enables remote stimulation of mechanosensitive ion channels using functionalised magnetic nanoparticles, enhancing extracellular vesicle (EV) biogenesis is pre‐osteoblasts. MICA desrived EVs exhibit typical nano‐vesicular characteristics but display superior pro‐osteogeneic activity, promoting mesenchymal stem ...
Afeesh Rajan Unnithan, Kenny Man, Kritika, Lee A. Gethings, Christopher J. Hughes, Alicia Keenan, Liam Heaney, Sophie C. Cox, Owen G. Davies, Alicia J. El Haj   +9 more
wiley   +1 more source

Micro-/nano-structured zirconia surface promotes osteogenic differentiation of human bone marrow mesenchymal stem cells by reducing pyroptosis under inflammatory conditions

Journal of Dental Sciences
Background/purpose: Promoting osteogenesis under inflammatory conditions holds promise for preventing and mitigating peri-implantitis. Cell pyroptosis inhibits osteoblast-mediated bone formation.
Hui-Min Wang, Qian Ding, Ying Chen, Yao-Jun Zhang, Zhi-Xiao Wu, Xiao Zhang, Lei Zhang   +6 more
doaj   +1 more source

Human Bone Marrow Stromal Cells Differentiate into Corneal Tissue and Prevent Ocular Graft-Versus-Host Disease in Mice

Cell Transplantation, 2015
Clinical trials have assessed the use of human bone marrow stromal cells (hBMSCs) for the treatment of immune-related disorders such as graft-versus-host disease (GVHD).
Luis Ignacio Sánchez-Abarca, Emiliano Hernández-Galilea M.D., Rebeca Lorenzo, Carmen Herrero, Almudena Velasco, Soraya Carrancio, Teresa Caballero-Velázquez, José Ignacio Rodríguez-Barbosa, Marta Parrilla, Consuelo Del Cañizo, Jesús San Miguel, José Aijón, José Antonio Pérez-Simón M.D., Ph.D.   +12 more
doaj   +1 more source

Bone marrow mesenchymal stem cells transplantation promotes the release of endogenous erythropoietin after ischemic stroke

Neural Regeneration Research, 2015
This study investigated whether bone marrow mesenchymal stem cell (BMSC) transplantation protected ischemic cerebral injury by stimulating endogenous erythropoietin.
Wen Lv, Wen-yu Li, Xiao-yan Xu, Hong Jiang, Oh Yong Bang   +4 more
doaj   +1 more source

Effects of miR-103 by negatively regulating SATB2 on proliferation and osteogenic differentiation of human bone marrow mesenchymal stem cells.

PLoS ONE, 2020
BACKGROUND:The proliferation and osteogenic differentiation of human bone marrow mesenchymal stem cells (HBMScs) are modulated by a variety of microRNAs (miRNAs). SATB homeobox 2 (SATB2) is a critical transcription factor that contributes to maintain the
Hao Lv, Huashan Yang, Yuanrui Wang
doaj   +1 more source

Beyond osteogenesis: an in vitro comparison of the potentials of six bone morphogenetic proteins [PDF]

, 2013
Bone morphogenetic proteins (BMPs) other than the clinically available BMP-2 and BMP-7 may be useful for improving fracture healing through both increasing osteogenesis and creating a favorable healing environment by altering cytokine release by ...
Cassandra A. Strohbach, Christopher R. Rathbone, Jessica C. Rivera, Joseph C. Wenke   +3 more
core   +2 more sources

Retracted: Overexpression of RPN2 promotes osteogenic differentiation of hBMSCs through the JAK/STAT3 pathway [PDF]

FEBS Open Bio, 2019
Osteoporosis is characterized by decreased bone mass and degenerating bone structure, which cause severe bone fragility and increase the risk for fractures. Human bone mesenchymal stem cells (hBMSCs) differentiate into osteoblasts through osteogenesis, and disturbances in the balance between bone generation and degeneration underlie the pathogenesis of
Ling Ni, Jianhua Yu, Xueqiong Gui, Zhonghua Lu, Xiwen Wang, Hongyan Guo, Ying Zhou   +6 more
openaire   +3 more sources

Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez, Maria Paula Marks, Paula Casademunt, Adrián Seijas‐Gamardo, Ioannis Papantoniou, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source

LINC00473 regulated apoptosis, proliferation and migration but could not reverse cell cycle arrest of human bone marrow mesenchymal stem cells induced by a high-dosage of dexamethasone

Stem Cell Research, 2020
Dysfunction of bone marrow mesenchymal stem cells (BMSCs) is involved in the pathogenesis of steroid-induced osteonecrosis of the femoral head (SONFH).
Yingxing Xu, Yaping Jiang, Yingzhen Wang, Yuanzhong Ren, Zhiping Zhao, Teng Wang, Tao Li   +6 more
doaj   +1 more source