Results 61 to 70 of about 3,978 (176)

Bone Marrow Mesenchymal Stem Cells' Secretome Exerts Neuroprotective Effects in a Parkinson's Disease Rat Model

Frontiers in Bioengineering and Biotechnology, 2019
Parkinson's disease (PD) is characterized by a selective loss of dopamine (DA) neurons in the human midbrain causing motor dysfunctions. The exact mechanism behind dopaminergic cell death is still not completely understood and, so far, no cure or ...
Bárbara Mendes-Pinheiro, Bárbara Mendes-Pinheiro, Sandra I. Anjo, Bruno Manadas, Jorge D. Da Silva, Jorge D. Da Silva, Ana Marote, Ana Marote, Leo A. Behie, Fábio G. Teixeira, Fábio G. Teixeira, António J. Salgado, António J. Salgado   +12 more
doaj   +1 more source

m6A‐modified DRAM1 recognized by YTHDF1 regulates autophagy during dexamethasone‐induced osteogenic inhibition

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
DRAM1 plays a critical role in the modulation of autophagy. The m6A methylation level of DRAM1 mRNA is suppressed by dexamethasone. Dexamethasone impairs autophagy‐associated osteogenic differentiation by inhibiting YTHDF1‐mediated translation of m6A‐modified DRAM1.
Ze‐Yu Lu, Peng‐Bo Chen, Qing‐Yin Xu, Muradil Mardan, Yue‐Hua Yang, Tao Liu, Wen‐Ning Xu, Huo‐Liang Zheng, Hao Cai, Hui Deng, Xing‐Xu Huang, Bo Li, Sheng‐Dan Jiang, Lei‐Sheng Jiang, Xin‐Feng Zheng   +14 more
wiley   +1 more source

Effects of high glucose on osteogenic differentiation of hBMSC

口腔疾病防治, 2017
Objective To investigate the effects of different glucose concentration on the proliferation and osteogen⁃ ic differentiation of human bone marrow mesenchymal stem cells (hBMSC) in vivo. Methods Cultured with basal medi⁃ um containing different glucose concentrations, CCK⁃8 cell proliferation was detected at 1, 4, 7, 10 days.
GAO Hai, CHEN Xiao, GUAN Dong⁃hua, ZHANG Ying⁃jie, LIN Chang⁃lü   +4 more
openaire   +1 more source

MiR-920 promotes osteogenic differentiation of human bone mesenchymal stem cells by targeting HOXA7

Journal of Orthopaedic Surgery and Research, 2020
Background To explore the effect of miR-920 on osteogenic differentiation of human bone mesenchymal stem cells (hBMSCs) and the possible mechanism. Methods Osteoporosis (OP) and healthy control bone tissues were collected, and the relative expression of ...
Jun-pu Zha, Xiao-qing Wang, Jun Di
doaj   +1 more source

Biodegradable Natural Polymer‐Based Drug Delivery Systems for Bone Tissue Engineering

Medicinal Research Reviews, Volume 46, Issue 4, Page 966-988, July 2026.
ABSTRACT The increasing incidence of bone diseases and injuries, especially among aging populations, has underscored the shortcomings of traditional treatments such as bone grafts and metal implants, which often face complications including immune rejection, mechanical failure, and delayed healing.
Hyejin Jo, Shinwon Kang, Jae Eun Yang, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Copper Nanocrystallization in Anodic Oxide Films of Ti–Cu‐Based Bulk Metallic Glass and Its Effect on the Corrosion Resistance and Cytocompatibility

Advanced Engineering Materials, Volume 28, Issue 11, 3 June 2026.
Viktoriia Shtefan, Thorgund Nemec, Ute Hempel, Annett Gebert and coworkers demonstrate that anodic treatment of Ti–Cu‐based metallic glass in a nontoxic pyrophosphate electrolyte forms a protective bilayered Ti/Zr‐oxide film enriched with Cu nanocrystals.
Viktoriia Shtefan, Nora Fernández Navas, Thorgund Nemec, Ivan Kaban, Ute Hempel, Andrea Voss, Volker Hoffmann, Darius Pohl, Annett Gebert   +8 more
wiley   +1 more source

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, Volume 15, Issue 23, 19 June 2026.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Improving Bone Regeneration Using Chordin siRNA Delivered by pH-Responsive and Non-Toxic Polyspermine Imidazole-4,5-Imine

Cellular Physiology and Biochemistry, 2018
Background/Aims: Bone nonunion remains a challenge for orthopaedists. The technological advancements that have been made in precisely silencing target genes have provided promising methods to address this challenge.
Chuandong Wang, Fei Xiao, Yaokai Gan, Weien Yuan, Zhanjing Zhai, Tuo Jin, Xiaodong Chen, Xiaoling Zhang   +7 more
doaj   +1 more source

3D‐Printed Piezoionic/Bioelectronic Hydrogel for Electro‐Metabolic Regulation of Osteogenic Differentiation

Advanced Healthcare Materials, Volume 15, Issue 24, 25 June 2026.
A 3D‐printed piezoionic GPMx hydrogel enables stable electromechanical signal generation under mechanical loading, exhibiting long‐term durability and low fatigue. As a bioactive patch, it restores endogenous bioelectricity to stimulate osteogenesis via Ca2+ influx and mitochondrial activation, while simultaneously enabling label‐free alkaline ...
Sayan Deb Dutta, Myoung Joon Jeon, Youjin Seol, Ki‐Taek Lim   +3 more
wiley   +1 more source

Osteoblastic differentiation and potent osteogenicity of three-dimensional hBMSC-BCP particle constructs.

Journal of tissue engineering and regenerative medicine, 2014
Bone tissue engineering usually consists of associating osteoprogenitor cells and macroporous scaffolds. This study investigated the in vitro osteoblastic differentiation and resulting in vivo bone formation induced by a different approach that uses particles as substrate for human bone marrow stromal cells (hBMSCs), in order to provide cells with a ...
Cordonnier, Thomas, Langonné, Alain, Corre, Pierre, Renaud, Audrey, Sensebe, Luc, Rosset, Philippe, Layrolle, Pierre, Sohier, Jérôme   +7 more
openaire   +3 more sources