Results 81 to 90 of about 3,978 (176)

LINC00662 regulates osteogenic differentiation of BMSCs and inhibits fracture healing via miR-330-3p/PTEN axis

BMC Musculoskeletal Disorders
Background Surgical treatment alone is not effective in addressing delayed fracture healing (DFH). This study nvestigates the molecular mechanism underlying fracture healing to identify improved therapeutic strategies.
Jiawei Gong, Jiehua Luo, Teng Zeng, Liping Zhu, Huasong Luo, Kun Ding, Mohamed Lamin Bangura, Jinliang Ma, Yunfeng Lv   +8 more
doaj   +1 more source

Expression of CD24 in Human Bone Marrow-Derived Mesenchymal Stromal Cells Is Regulated by TGFβ3 and Induces a Myofibroblast-Like Genotype

Stem Cells International, 2016
Human bone marrow-derived stromal cells (hBMSCs) derived from the adult organism hold great promise for diverse settings in regenerative medicine. Therefore a more complete understanding of hBMSC biology to fully exploit the cells’ potential for clinical
Luisa Marilena Schäck, Manuela Buettner, Alexander Wirth, Claudia Neunaber, Christian Krettek, Andrea Hoffmann, Sandra Noack   +6 more
doaj   +1 more source

Microdroplets Encapsulated with NFATc1-siRNA and Exosomes-Derived from MSCs Onto 3D Porous PLA Scaffold for Regulating Osteoclastogenesis and Promoting Osteogenesis

International Journal of Nanomedicine
Peng Luo,1,* Yi Zhang,2,3,* Maodi Huang,1 Guochen Luo,1 Yaping Ma,1,4 Xin Wang1,4 1Department of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563003, People’s Republic of China; 2Department of Hygiene ...
Luo P, Zhang Y, Huang M, Luo G, Ma Y, Wang X   +5 more
doaj  

Effect of monocytes/macrophages on the early osteogenic differentiation of hBMSCs [PDF]

Journal of Tissue Engineering and Regenerative Medicine, 2012
R. P. Pirraco, R. L. Reis, A. P. Marques
openaire   +1 more source

PCBP2 as an intrinsic aging factor regulates the senescence of hBMSCs through the ROS-FGF2 signaling axis

eLife
Background: It has been reported that loss of PCBP2 led to increased reactive oxygen species (ROS) production and accelerated cell aging. Knockdown of PCBP2 in HCT116 cells leads to significant downregulation of fibroblast growth factor 2 (FGF2).
Pengbo Chen, Bo Li, Zeyu Lu, Qingyin Xu, Huoliang Zheng, Shengdan Jiang, Leisheng Jiang, Xinfeng Zheng   +7 more
doaj   +1 more source

Cb1 Enhanced Osteogenic Differentiation Of Bmscs By Rescue Mitochondrial Metabolism

International Dental Journal
Aim or purpose: CB1 is the main effector of endogenous cannabinoid system, and our previous study verified CB1 enhanced the osteo/dentinogenic differentiation of dental mesenchymal stem cells (MSCs), which might be a target for alveolar bone regeneration.
Wanhao Yan
doaj   +1 more source

Bone potential heterogeneity in hBMSCs is associated with their immunomodulatory capacity

Bone Reports, 2020
Raddi, Najat, Coquelin, Laura, Vidal, Luciano, Zazou, Sanae, Windels, Gabriel, Mebarki, Miryam, Manassero, Mathieu, Rouard, Hélène, Chevallier, Nathalie   +8 more
openaire   +3 more sources

Polydeoxyribonucleotide ameliorates IL-1β-induced impairment of chondrogenic differentiation in human bone marrow-derived mesenchymal stem cells

Scientific Reports
Osteoarthritis (OA) is a degenerative disease of the joints, prevalent worldwide. Polydeoxyribonucleotide (PDRN) is used for treating knee OA. However, the role of PDRN in IL-1β-induced inflammatory responses in human bone marrow-derived mesenchymal stem
Ahreum Baek, Dawoon Baek, Sung Hoon Kim, Jinyoung Kim, Geneva Rose Notario, Do‑Won Lee, Hyun Jung Kim, Sung-Rae Cho   +7 more
doaj   +1 more source

Loss of BACH1 improves osteogenic differentiation in glucocorticoid-induced hBMSCs through restoring autophagy

BMC Musculoskeletal Disorders
Glucocorticoid-induced osteoporosis (GIOP) is the most common type of secondary osteoporosis. Recently, autophagy has been found to be related with the development of various diseases, including osteoporosis and osteoblast differentiation regulations.
ShuYing Xiao, GuoJuan Li, MeiHua Tan, Wen Liu, WenJin Li   +4 more
openaire   +3 more sources

ZFP36, an RNA-binding protein promotes hBMSCs osteogenic differentiation via binding with JUN

Journal of Orthopaedic Surgery and Research
Abstract Osteoporosis (OP) is a metabolic bone disease characterized by progressive decline of bone mass and bone quality, leading to bone fragility and an increased risk of fracture. The osteogenic differentiation of bone mesenchymal stem cells (BMSCs) is crucial to maintain the balance of osteoblast and osteoclast.
Hairong Su, Linyuan Liang, Junling Wang, Xiaolu Yuan, Binxiu Zhao   +4 more
openaire   +3 more sources