Results 81 to 90 of about 5,228 (216)

Engineering Multi‐Spheroid Bone Constructs Through the Fusion of Large MSC Spheroids

Journal of Orthopaedic Research, Volume 44, Issue 9, September 2026.
ABSTRACT Bone tissue engineering offers the promise of creating alternatives to bone grafts to facilitate defect repair. Although many different approaches have been investigated, recent work has focused on harnessing the potential of scaffold‐free approaches, such as spheroids, to create viable engineered bone tissue.
Peter Zastawny, Stephen D. Waldman
wiley   +1 more source

Morphology of hBMSCs cultured on Ta and Ti coatings.

, 2013
(A) SEM images of the surface morphology of both coatings with cultured hBMSCs at 800× magnifications. (B) Confocal laser scanning microscopy images of single hBMSC F-actin cytoskeletal morphology on both coatings for 3 and 24 h.
Youtao Xie (420382), Yan Huang (46805), Fei Yang (46361), Xuebin Zheng (386179), Kerong Dai (387141), Chuandong Wang (420383), Ze Tang (420381), Xiaoling Zhang (420384)   +7 more
core   +1 more source

Effects of high glucose on osteogenic differentiation of hBMSC

口腔疾病防治, 2017
Objective To investigate the effects of different glucose concentration on the proliferation and osteogen⁃ ic differentiation of human bone marrow mesenchymal stem cells (hBMSC) in vivo. Methods Cultured with basal medi⁃ um containing different glucose concentrations, CCK⁃8 cell proliferation was detected at 1, 4, 7, 10 days.
GAO Hai, CHEN Xiao, GUAN Dong⁃hua, ZHANG Ying⁃jie, LIN Chang⁃lü   +4 more
openaire   +1 more source

Overexpression of MiR-183/96/182 Triggers Retina-Like Fate in Human Bone Marrow-Derived Mesenchymal Stem Cells (hBMSCs) in Culture [PDF]

, 2019
Retinal degeneration is considered as a condition ensued by different blinding disorders such as retinitis pigmentosa, age-related macular degeneration, and diabetic retinopathy, which can cause loss of photoreceptor cells and also lead to significant ...
Mohammad-Reza Mahmoudian-Sani, Mahmoudian-Sani, Mohammad-Reza, Nilufar Ghorbani, Samira Asgharzade, Ghorbani, Nilufar, Forouzanfar, Fatemeh, Fatemeh Forouzanfar, Asgharzade, Samira   +7 more
core   +2 more sources

Bone Marrow Mesenchymal Stem Cells' Secretome Exerts Neuroprotective Effects in a Parkinson's Disease Rat Model

Frontiers in Bioengineering and Biotechnology, 2019
Parkinson's disease (PD) is characterized by a selective loss of dopamine (DA) neurons in the human midbrain causing motor dysfunctions. The exact mechanism behind dopaminergic cell death is still not completely understood and, so far, no cure or ...
Bárbara Mendes-Pinheiro, Bárbara Mendes-Pinheiro, Sandra I. Anjo, Bruno Manadas, Jorge D. Da Silva, Jorge D. Da Silva, Ana Marote, Ana Marote, Leo A. Behie, Fábio G. Teixeira, Fábio G. Teixeira, António J. Salgado, António J. Salgado   +12 more
doaj   +1 more source

Priming with interleukin‐1α and chemical hypoxia modulates the mesenchymal stem cell secretome to dampen microglial inflammation and promote neuroprotection

British Journal of Pharmacology, Volume 183, Issue 17, Page 5355-5371, September 2026.
Abstract Background and Purpose We hypothesised that dual priming of human bone marrow‐derived human mesenchymal stem cells (hBMSCs) with interleukin‐1alpha (IL‐1α) and CoCl2 (a hypoxia mimetic) would modulate their therapeutic efficacy for hypoxic‐ischaemic conditions. Experimental Approach hBMSCs were primed individually or in combination.
Maryam Adenike Salaudeen, Stuart M. Allan, Emmanuel Pinteaux   +2 more
wiley   +1 more source

MiR-920 promotes osteogenic differentiation of human bone mesenchymal stem cells by targeting HOXA7

Journal of Orthopaedic Surgery and Research, 2020
Background To explore the effect of miR-920 on osteogenic differentiation of human bone mesenchymal stem cells (hBMSCs) and the possible mechanism. Methods Osteoporosis (OP) and healthy control bone tissues were collected, and the relative expression of ...
Jun-pu Zha, Xiao-qing Wang, Jun Di
doaj   +1 more source

Oxygen Vacancy‐Enriched Platinum Single‐Atom Nanozyme Wrapped in Nanoislands: Unlocking Catalytic Activity and Reprogramming Redox Microenvironment for Osteonecrosis Repair

Advanced Science, Volume 13, Issue 47, 24 August 2026.
CeO2‐x/Pt single‐atom nano‐island is constructed via low‐temperature reduction, featuring abundant oxygen vacancies and an island–sea structure. It delivers outstanding multi‐enzyme‐mimetic activity and ROS‐scavenging efficiency. Density functional theory reveals optimized electronic structures and reaction pathways.
Yang Zhu, Zehui Lv, Xuejie Cai, Penghui Wei, Dengliang Wang, Zhao Wang, Ruoying Wang, Yingjie Wang, Xingdong Yang, Yixin Bian, Jiawei Xu, Xisheng Weng, Liangfeng Wei   +12 more
wiley   +1 more source

Identification and Validation of a New Functional Gene TSC22D3 for hBMSCs Osteogenesis

Stem Cells International
Background Osteogenic differentiation is a crucial process in which bone marrow mesenchymal stem cells (BMSCs) differentiate into osteoblasts, involving the regulation of multiple genes and signaling pathways.
Shuhong Zhang, Xiao Li, Zhanping Yang, Jialong Li, Gang Liu, Yongkun Sun, Huigen Feng, Xianwei Wang   +7 more
openaire   +2 more sources

Evaluation of Boron/Strontium Co‐Substituted‐Hydroxyapatite Incorporated Collagen Composite Scaffolds: Physicochemical, Thermal, Mechanical, Biological, and Sustained‐Release Investigations

Macromolecular Materials and Engineering, Volume 311, Issue 8, August 2026.
A collagen‐based composite scaffold containing boron/strontium co‐substituted hydroxyapatite is developed to enhance the bioactivity of collagen through the incorporation of bioactive ions. This composite exhibits good stability and improved mechanical properties compared to collagen.
Hamideh Karimi, Eylül Odabaş‐Kansız, Seyithan Kansız, Ayşe Eser Elçin, Yaşar Murat Elçin   +4 more
wiley   +1 more source