Results 91 to 100 of about 5,228 (216)

Improving Bone Regeneration Using Chordin siRNA Delivered by pH-Responsive and Non-Toxic Polyspermine Imidazole-4,5-Imine

Cellular Physiology and Biochemistry, 2018
Background/Aims: Bone nonunion remains a challenge for orthopaedists. The technological advancements that have been made in precisely silencing target genes have provided promising methods to address this challenge.
Chuandong Wang, Fei Xiao, Yaokai Gan, Weien Yuan, Zhanjing Zhai, Tuo Jin, Xiaodong Chen, Xiaoling Zhang   +7 more
doaj   +1 more source

Aqueous Two‐Phase Bioinks for Discrete Packing and Compartmentalization of 3D Bioprinted Cells

Advanced Healthcare Materials, Volume 15, Issue 25, 3 July 2026.
Aqueous two‐phase systems (ATPS) enable the formation of biomimetic interfaces crucial for tissue engineering. However, clinical translation remains limited by the challenge of precisely controlling cellular compartmentalization. Here, we developed ATPS biomaterial inks for 3D bioprinting allowing tuneable droplet formation via NaCl modulation.
Martina Marcotulli, Arianna Iacomino, Federico Serpe, Lucia Iafrate, Marco Bastioli, Giorgia Montalbano, Michele D'Orazio, Biagio Palmisano, Silvia Franco, Arianna Mencattini, Roberta Angelini, Eugenio Martinelli, Alessandro Corsi, Mara Riminucci, Giancarlo Ruocco, Chiara Scognamiglio, Andrea Barbetta, Gianluca Cidonio   +17 more
wiley   +1 more source

Influence of scaffold composition over in vitro osteogenic differentiation of hBMSCs and in vivo inflammatory response

Journal of Biomaterials Applications, 2013
To understand the role of chitosan in chitosan-poly(butylene succinate) scaffolds (50% wt), 50%, 25%, and 0% of chitosan were used to produce different scaffolds. These scaffolds were in vitro seeded and cultured with human bone marrow stromal cells in osteogenic conditions, revealing that higher percentage of chitosan showed enhanced cell viability ...
Pinto, A. R., Vargel, I., Tuzlakoglu, K., Correlo, V. M., Sol, P. C., Faria, Susana, Piskin, Erhan, Reis, R. L., Neves, N. M.   +8 more
openaire   +4 more sources

Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

Advanced Healthcare Materials, Volume 15, Issue 27, 17 July 2026.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez, Maria Paula Marks, Paula Casademunt, Adrián Seijas‐Gamardo, Ioannis Papantoniou, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source

hBMSCs phenotyping and differentiation.

, 2018
Dot plot graphs illustrate the presence/absence of mesenchymal cell surface markers, performed by flow cytometry analysis on hBMSCs. (A) CD166 and CD105 positive cells are sorted into the upper right quadrant (UR) (98.94%) and (B) CD34 and CD45 negative ...
Geórgia da Silva Feltran (4089847), Karina G. Silvério (6037934), Enilson A. Sallum (2697061), Malgorzata Wiench (6037931), Rodrigo A. da Silva (6037937), Francisco H. Nociti Jr (6037940), Rahyza I. F. Assis (6037928), Denise C. Andia (6037943), Marcio Z. Casati (3878761)   +8 more
core   +1 more source

Osteoblastic differentiation and potent osteogenicity of three-dimensional hBMSC-BCP particle constructs.

Journal of tissue engineering and regenerative medicine, 2014
Bone tissue engineering usually consists of associating osteoprogenitor cells and macroporous scaffolds. This study investigated the in vitro osteoblastic differentiation and resulting in vivo bone formation induced by a different approach that uses particles as substrate for human bone marrow stromal cells (hBMSCs), in order to provide cells with a ...
Cordonnier, Thomas, Langonné, Alain, Corre, Pierre, Renaud, Audrey, Sensebe, Luc, Rosset, Philippe, Layrolle, Pierre, Sohier, Jérôme   +7 more
openaire   +3 more sources

Biodegradable Natural Polymer‐Based Drug Delivery Systems for Bone Tissue Engineering

Medicinal Research Reviews, Volume 46, Issue 4, Page 966-988, July 2026.
ABSTRACT The increasing incidence of bone diseases and injuries, especially among aging populations, has underscored the shortcomings of traditional treatments such as bone grafts and metal implants, which often face complications including immune rejection, mechanical failure, and delayed healing.
Hyejin Jo, Shinwon Kang, Jae Eun Yang, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Expression levels of miR-346 during osteogenic differentiation of hBMSCs.

, 2013
(A) qRT-PCR analysis of the osteoblastic marker genes RUNX2, ALP, and OPN. β-actin was used as an internal control. (B) ALP staining and Alizarin Red staining were performed at day 10 and day 15, respectively.
Qing Wang (27728), Jie Cai (389349), Lei Chen (54296), Xian-hua Cai (454113)   +3 more
core   +1 more source

Lower Extent but Similar Rhythm of Osteogenic Behavior in hBMSCs Cultured on Nanofibrous Scaffolds versus Induced with Osteogenic Supplement

, 2016
Nanotopographic cues from biomaterials exert powerful effects on the osteogenic differentiation of mesenchymal stem cells because of their niche-mimicking features.
Mingming Xu (649152), Yan Wei (32168), Xuliang Deng (306023), Xiaoping Yang (460478), Xuehui Zhang (1920034), Wentao Liu (1447222)   +5 more
core   +1 more source

Insulin/IGF1 receptor signaling pathway in the pancreas of diabetic mice, healthy control mice and mice rescued by hBMSCs-VEGF: PCR array profile.

, 2013
Figure 7 shows fold changes of various gene expression in diabetic mice (STZ) compared with ones in healthy control (A); mice rescued by hBMSCs-VEGF compared with healthy control mice (B); mice rescued by hBMSCs-VEGF compared with diabetic mice (C ...
Jang-Won Lee (312197), Stefano Da Sacco (252951), Laura Perin (252948), Valentina Villani (312201), Vanessa Cervantes (312203), John S. Yu (312205), Anna Milanesi (312195), Zhenhua Li (312199)   +7 more
core   +1 more source