Results 111 to 120 of about 5,228 (216)

Loss of BACH1 improves osteogenic differentiation in glucocorticoid-induced hBMSCs through restoring autophagy

BMC Musculoskeletal Disorders
Glucocorticoid-induced osteoporosis (GIOP) is the most common type of secondary osteoporosis. Recently, autophagy has been found to be related with the development of various diseases, including osteoporosis and osteoblast differentiation regulations.
ShuYing Xiao, GuoJuan Li, MeiHua Tan, Wen Liu, WenJin Li   +4 more
openaire   +3 more sources

LINC00662 regulates osteogenic differentiation of BMSCs and inhibits fracture healing via miR-330-3p/PTEN axis

BMC Musculoskeletal Disorders
Background Surgical treatment alone is not effective in addressing delayed fracture healing (DFH). This study nvestigates the molecular mechanism underlying fracture healing to identify improved therapeutic strategies.
Jiawei Gong, Jiehua Luo, Teng Zeng, Liping Zhu, Huasong Luo, Kun Ding, Mohamed Lamin Bangura, Jinliang Ma, Yunfeng Lv   +8 more
doaj   +1 more source

Expression of CD24 in Human Bone Marrow-Derived Mesenchymal Stromal Cells Is Regulated by TGFβ3 and Induces a Myofibroblast-Like Genotype

Stem Cells International, 2016
Human bone marrow-derived stromal cells (hBMSCs) derived from the adult organism hold great promise for diverse settings in regenerative medicine. Therefore a more complete understanding of hBMSC biology to fully exploit the cells’ potential for clinical
Luisa Marilena Schäck, Manuela Buettner, Alexander Wirth, Claudia Neunaber, Christian Krettek, Andrea Hoffmann, Sandra Noack   +6 more
doaj   +1 more source

hUCMSCs secretion factors up-regulated expression of osteogenic marker genes of hBMSCs.

, 2015
hBMSCs were incubated with 20 μg/ml hUCMSCs secretion, osteogenic induction medium and osteogenic induction medium with 20 μg/ml hUCMSCs secretion for 11 days before RNA extraction and real time qRT-PCR.
Yun-Feng Rui (709357), Ying-Hui Li (315831), Wayne Yuk-Wai Lee (709360), Shuo Huang (624671), Si-En Lin (709358), Gang Li (34549), Kui-Xing Wang (709355), Liang-Liang Xu (709356), Jiang-Hui Xiong (709359)   +8 more
core   +1 more source

Cells on scaffolds after 21 days in osteogenic and control cultures: (a and c) hASCs and hBMSCs from osteogenic culture; (e and g) hASCs and hBMSCs from control culture.

, 2015
High magnification images showing calcium phosphate deposits of hASCs and hBMSCs cultured on Zr-Si scaffolds in osteogenic (b and d) and control (f and h) conditions; (i-l) EDX mapping confirming the presence of calcium and phosphor in the accumulations.
Viktor Bagratashvili (695032), Andrea Deiwick (384833), Sabrina Schlie-Wolter (695028), Anastasia Koroleva (695026), Boris Chichkov (384834), Alexander Nguyen (695027), Vladimir Popov (695031), Roger Narayan (695029), Peter Timashev (695030)   +8 more
core   +1 more source

Gelatin/Cerium-Doped Bioactive Glass Composites for Enhancing Cellular Functions of Human Mesenchymal Stem Cells (hBMSCs)

Delayed or non-healing of bone defects in an aging, multi-morbid population is still a medical challenge. Current replacement materials, like autografts, are limited.
Hans-PeterWiesmann, Andrey Iodchik, Poh Soo Lee, Anne Bernhardt, Anne Bernhard, Gigliola Lusvardi, Alfonso Zambon, Vera Hintze, Hans-Peter Wiesmann   +8 more
core   +1 more source

Polydeoxyribonucleotide ameliorates IL-1β-induced impairment of chondrogenic differentiation in human bone marrow-derived mesenchymal stem cells

Scientific Reports
Osteoarthritis (OA) is a degenerative disease of the joints, prevalent worldwide. Polydeoxyribonucleotide (PDRN) is used for treating knee OA. However, the role of PDRN in IL-1β-induced inflammatory responses in human bone marrow-derived mesenchymal stem
Ahreum Baek, Dawoon Baek, Sung Hoon Kim, Jinyoung Kim, Geneva Rose Notario, Do‑Won Lee, Hyun Jung Kim, Sung-Rae Cho   +7 more
doaj   +1 more source

PCBP2 as an intrinsic aging factor regulates the senescence of hBMSCs through the ROS-FGF2 signaling axis

eLife
Background: It has been reported that loss of PCBP2 led to increased reactive oxygen species (ROS) production and accelerated cell aging. Knockdown of PCBP2 in HCT116 cells leads to significant downregulation of fibroblast growth factor 2 (FGF2).
Pengbo Chen, Bo Li, Zeyu Lu, Qingyin Xu, Huoliang Zheng, Shengdan Jiang, Leisheng Jiang, Xinfeng Zheng   +7 more
doaj   +1 more source

Insulin/IGF1 receptor/PI-3K/AKT pathway in the pancreas of diabetic mice, healthy control mice, and mice rescued by hBMSCs-VEGF.

, 2013
Immunostaining of pancreatic sections from control healthy mice (control), diabetic mice (STZ), and diabetic mice rescued by hBMSCs-VEGF (hBMSC-VEGF) for AKT (green), insulin (red) and merge in yellow (A); PDX1 (green) and insulin (red) (B); p27-kip1 ...
Jang-Won Lee (312197), Stefano Da Sacco (252951), Laura Perin (252948), Valentina Villani (312201), Vanessa Cervantes (312203), John S. Yu (312205), Anna Milanesi (312195), Zhenhua Li (312199)   +7 more
core   +1 more source

Macromolecular modulation in a tissue-to-tissue model system differentially regulates the behaviour of hBMSCs [PDF]

, 2016
The simultaneous creation of multiple tissues and their functional assembly leading to complex organ systems has recently created interest in tissue engineering strategies.
Pereira, Diana Ribeiro, Pandit, A., Reis, R. L., Oliveira, J. M.   +3 more
core   +1 more source