Results 71 to 80 of about 6,219 (219)

Erythropoietin mediated bone formation is regulated by mTOR signaling [PDF]

, 2012
The role of erythropoietin (Epo) and Epo/Epo receptor (EpoR) signaling pathways for production of red blood cells are well established. However, little is known about Epo/EpoR signaling in non‐hematopoietic cells.
Acs, Anagnostou, Arcasoy, Bab, Bashutski, Bianchi, Brager, Brines, Calvillo, Celik, Domracheva, Flanagan, Foldes, Frias, Glantschnig, Gorio, Grasso, Henke, Hong, Inoki, Isomoto, Jacinto, Jelkmann, Kim, Lee, Lee, Lucas, Martin, Masuda, Mogi, Niziolek, Nojima, Phornphutkul, Richmond, Sanchez, Sarbassov, Shiozawa, Shoba, Singbrant, Singha, Smink, Sugatani, Szenajch, Vander Haar, Yamaji, Yazigi, Zoncu   +46 more
core   +1 more source

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Chordin-Like 1 Improves Osteogenesis of Bone Marrow Mesenchymal Stem Cells Through Enhancing BMP4-SMAD Pathway

Frontiers in Endocrinology, 2019
Chordin-like 1 (CHRDL1) is a secreted glycoprotein with repeated cysteine-rich domains, which can bind to BMPs family ligands. Although it has been reported to play important roles in several systems, the exact roles of CHRDL1 on human bone mesenchymal ...
Tao Liu, Bo Li, Xin-Feng Zheng, Sheng-Dan Jiang, Ze-Zhu Zhou, Wen-Ning Xu, Huo-Liang Zheng, Chuan-Dong Wang, Xiao-Ling Zhang, Lei-Sheng Jiang   +9 more
doaj   +1 more source

Impact of transient down-regulation of DREAM in human embryonic stem cell pluripotency: The role of DREAM in the maintenance of hESCs [PDF]

, 2016
Little is knownabout the functions of downstreamregulatory element antagonist modulator (DREAM) inembryonic stem cells (ESCs). However, DREAM interacts with cAMP response element-binding protein (CREB) in a Ca2+-dependent manner, preventing CREB ...
Aguilera, Yolanda, Capilla González, Vivian, Carrión Rodríguez, Ángel Manuel, Fontán Lozano, Ángela del Carmen, Hmadcha, Abdelkrim, Mellado, Nuria, Soria Escoms, Bernat   +6 more
core   +1 more source

Nanoclay‐Engineered Scaffolds for the Controlled Delivery of Biomolecules in Regenerative Medicine

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Regenerative medicine combines biomaterials, cells, scaffolds, and bioactive agents via modern technologies to aid in the reconstruction and repair of damaged tissues. Among these, nanoclay scaffolds have demonstrated unique advantages in facilitating the delivery of therapeutic agents.
Mehri Shadi, Saeed Vafaei‐Nezhad, Ahmad Gholamalizadeh Ahangar   +2 more
wiley   +1 more source

Identification of a clinical signature predictive of differentiation fate of human bone marrow stromal cells

Stem Cell Research & Therapy, 2021
Background Transplantation of human bone marrow stromal cells (hBMSCs) is a promising therapy for bone regeneration due to their ability to differentiate into bone forming osteoblastic cells.
Justyna Magdalena Kowal, Sören Möller, Dalia Ali, Florence Figeac, Torben Barington, Hagen Schmal, Moustapha Kassem   +6 more
doaj   +1 more source

Biodegradable Natural Polymer‐Based Drug Delivery Systems for Bone Tissue Engineering

Medicinal Research Reviews, EarlyView.
ABSTRACT The increasing incidence of bone diseases and injuries, especially among aging populations, has underscored the shortcomings of traditional treatments such as bone grafts and metal implants, which often face complications including immune rejection, mechanical failure, and delayed healing.
Hyejin Jo, Shinwon Kang, Jae Eun Yang, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Compositional and in Vitro Evaluation of Nonwoven Type I Collagen/Poly-dl-lactic Acid Scaffolds for Bone Regeneration [PDF]

, 2015
Poly-dl-lactic acid (PDLLA) was blended with type I collagen to attempt to overcome the instantaneous gelation of electrospun collagen scaffolds in biological environments.
Qiao, X, Russell, SJ, Tronci, G, Wood, DJ, Yang, X   +4 more
core   +3 more sources

LncRNA USP2-AS1 facilitates the osteogenic differentiation of bone marrow mesenchymal stem cells by targeting KDM3A/ETS1/USP2 to activate the Wnt/β-catenin signaling pathway

RNA Biology
Human bone marrow mesenchymal stem cells (HBMSCs) can promote new bone formation. Previous studies have proven the ability of long non-coding RNAs (lncRNAs) to modulate the osteogenic differentiation of mesenchymal stem cells.
Wanxin Luo, Na Zhang, Ziping Wang, Hao Chen, Jie Sun, Chen Yao, Yafeng Zhang   +6 more
doaj   +1 more source

GPRC5B Identified by m5C meRIP‐Seq Suppresses Apoptosis in Osteosarcoma Through NSUN2‐Mediated RNA Methylation

Cancer Science, Volume 117, Issue 5, Page 1322-1332, May 2026.
We performed the first transcriptome‐wide profiling of m5C modifications in osteosarcoma, analyzing four pairs of tumor and adjacent normal tissues. We revealed that NSUN2 suppresses apoptosis in osteosarcoma cells by promoting GPRC5B m5C modification and expression.
Zhenyi Chen, Min Yang, Xiaoxiao Liang, Zhiqiang Yang, Wulan Mai, Yuyang Wang, Yushen Lu, Ruimin Wang, Yuanhang Han, Yuanlong Xie, Lin Cai   +10 more
wiley   +1 more source