Results 21 to 30 of about 3,978 (176)

Inflammatory Microenvironment Changes the Secretory Profile of Mesenchymal Stem Cells to Recruit Mesenchymal Stem Cells

Cellular Physiology and Biochemistry, 2014
Background/Aims: Human bone-marrow mesenchymal stem cells (hBMSCs) are widely transplanted into inflammatory microenvironment to accelerate tissue regeneration. Transplanted hBMSCs recruit host hBMSCs through a poorly understood mechanism. This study was
Junchao Xing, Tianyong Hou, Huiyong Jin, Fei Luo, Zhengqi Change, Zhiqiang Li, Zhao Xie, Jianzhong Xu   +7 more
doaj   +1 more source

Injectable platelet-rich fibrin positively regulates osteogenic differentiation of stem cells from implant hole via the ERK1/2 pathway

Platelets, 2023
Bone regeneration in dentistry is a dynamic approach for treating critical size bone defects that are unlikely to self-heal. Human bone marrow stem cell (hBMSCs) therapies are being tested clinically for various disorders and have remarkable clinical ...
Jia Wang, Wanxin Li, Xuxia He, Simei Li, Hongwei Pan, Lihua Yin   +5 more
doaj   +1 more source

Human Bone Marrow Stromal Cells Lose Immunosuppressive and Anti-inflammatory Properties upon Oncogenic Transformation

Stem Cell Reports, 2014
Because of their immunomodulatory properties, human bone marrow stromal cells (hBMSCs) represent promising stem cells for treatment of immune disorders.
Rene Rodriguez, Michael Rosu-Myles, Marcos Aráuzo-Bravo, Angélica Horrillo, Qiuwei Pan, Elena Gonzalez-Rey, Mario Delgado, Pablo Menendez   +7 more
doaj   +1 more source

Comparison of chondrogenesis-related biological behaviors between human urine-derived stem cells and human bone marrow mesenchymal stem cells from the same individual

Stem Cell Research & Therapy, 2021
Background Stem cells are the main choice for seed cells in tissue engineering, but using most traditional stem cells requires invasive and complicated procedures.
Jiachen Sun, Fei Xing, Min Zou, Min Gong, Lang Li, Zhou Xiang   +5 more
doaj   +1 more source

Effects of Extracellular Vesicles from Osteogenic Differentiated Human BMSCs on Osteogenic and Adipogenic Differentiation Capacity of Naïve Human BMSCs

Cells, 2022
Osteoporosis, or steroid-induced osteonecrosis of the hip, is accompanied by increased bone marrow adipogenesis. Such a disorder of adipogenic/osteogenic differentiation, affecting bone-marrow-derived mesenchymal stem cells (BMSCs), contributes to bone ...
Chenglong Wang, Sabine Stöckl, Shushan Li, Marietta Herrmann, Christoph Lukas, Yvonne Reinders, Albert Sickmann, Susanne Grässel   +7 more
doaj   +1 more source

Comparison of hIGF-1 Gene Transfection to the hBMSCs and Human Meniscal Fibrochondrocytes [PDF]

Medical Science Monitor, 2015
Treatment strategies for meniscal injury are shifting from meniscectomy to repair, especially cell-based therapy. Delivering selected genes to donor cells can modify differentiation and proliferation. Efficiency of gene transfection and expression may relate to cell type.Full-length hIGF-1 cDNA was cloned into eukaryotic expression vector by PCR. Human
Zhang, Haining, Leng, Ping, He, Tian, Wang, Yingzhen   +3 more
openaire   +2 more sources

RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival

Cell Death and Disease, 2022
Molecular understanding of osteogenic differentiation (OD) of human bone marrow-derived mesenchymal stem cells (hBMSCs) is important for regenerative medicine and has direct implications for cancer.
Rostislav Novak, Yamen Abu Ahmad, Michael Timaner, Eliya Bitman-Lotan, Avital Oknin-Vaisman, Roi Horwitz, Oliver Hartmann, Michaela Reissland, Viktoria Buck, Mathias Rosenfeldt, David Nikomarov, Markus Elmar Diefenbacher, Yuval Shaked, Amir Orian   +13 more
doaj   +1 more source

Metformin Ameliorates D-Galactose-Induced Senescent Human Bone Marrow-Derived Mesenchymal Stem Cells by Enhancing Autophagy

Stem Cells International, 2023
Human bone marrow-derived mesenchymal stem cells (hBMSCs) are promising candidates for stem cell therapy in clinical trials. Applications of hBMSCs in clinical therapy are limited by cellular senescence due to long-term ex vivo expansion.
Pingting Ye, Lei Feng, Dan Zhang, Ruihao Li, Yixuan Wen, Xiaohan Tong, Shuo Shi, Chunyan Dong   +7 more
doaj   +1 more source

Cell Membrane Vesicles Derived from Hbmscs and Huvecs Enhance Bone Regeneration

Bone Research, 2023
Abstract Bone tissue renewal can be enhanced through co-transplantation of bone mesenchymal stem cells (BMSCs) and vascular endothelial cells (ECs). However, there are apparent limitations in stem cell-based therapy which hinder its clinic translation.
Dandan Wang, Yaru Guo, Boon Chin Heng, Xuehui Zhang, Yan Wei, Ying He, Mingming Xu, Bin Xia, Xuliang Deng   +8 more
openaire   +3 more sources

Influence of Kartogenin on Chondrogenic Differentiation of Human Bone Marrow-Derived MSCs in 2D Culture and in Co-Cultivation with OA Osteochondral Explant

Molecules, 2018
Articular cartilage has limited capacity for natural regeneration and repair. In the present study, we evaluated kartogenin (KGN), a bioactive small heterocyclic molecule, for its effect on in vitro proliferation and chondrogenic differentiation of human
Timea Spakova, Jana Plsikova, Denisa Harvanova, Marek Lacko, Stefan Stolfa, Jan Rosocha   +5 more
doaj   +1 more source