Results 21 to 30 of about 6,219 (219)

The effects of bioactive akermanite on physiochemical, drug-delivery, and biological properties of poly(lactide-co-glycolide) beads [PDF]

, 2011
Poly(lactide-co-glycolide) (PLGA) beads have been widely studied as a potential drug/protein carrier. The main shortcomings of PLGA beads are that they lack bioactivity and controllable drug-delivery ability, and their acidic degradation by-products can ...
Ara, Bittner, Brunner, Cleland, Crotts, Dittrich, Fu, Heidemann, Hench, Hong, Huang, Jeyanthi, Johnson, Juin, Keshaw, Kim, Kokubo, Li, Maquet, Mondal, Nam, Shi, Silver, Teixeira, Valerio, Verrier, Wang, Wu, Wu, Wu, Wu, Wu, Zolnik, Zreiqat   +33 more
core   +2 more sources

Inflammatory Microenvironment Changes the Secretory Profile of Mesenchymal Stem Cells to Recruit Mesenchymal Stem Cells

Cellular Physiology and Biochemistry, 2014
Background/Aims: Human bone-marrow mesenchymal stem cells (hBMSCs) are widely transplanted into inflammatory microenvironment to accelerate tissue regeneration. Transplanted hBMSCs recruit host hBMSCs through a poorly understood mechanism. This study was
Junchao Xing, Tianyong Hou, Huiyong Jin, Fei Luo, Zhengqi Change, Zhiqiang Li, Zhao Xie, Jianzhong Xu   +7 more
doaj   +1 more source

Small molecule-mediated tribbles homolog 3 promotes bone formation induced by bone morphogenetic protein-2. [PDF]

, 2017
Although bone morphogenetic protein-2 (BMP2) has demonstrated extraordinary potential in bone formation, its clinical applications require supraphysiological milligram-level doses that increase postoperative inflammation and inappropriate adipogenesis ...
Aghaloo, Tara L, Cui, Zhong-Kai, Fan, Jiabing, Guo, Mian, Im, Dan CS, Kim, Soyon, Lee, Min, Pi-Anfruns, Joan, Wu, Benjamin M   +8 more
core   +1 more source

Human Bone Marrow Stromal Cells Lose Immunosuppressive and Anti-inflammatory Properties upon Oncogenic Transformation

Stem Cell Reports, 2014
Because of their immunomodulatory properties, human bone marrow stromal cells (hBMSCs) represent promising stem cells for treatment of immune disorders.
Rene Rodriguez, Michael Rosu-Myles, Marcos Aráuzo-Bravo, Angélica Horrillo, Qiuwei Pan, Elena Gonzalez-Rey, Mario Delgado, Pablo Menendez   +7 more
doaj   +1 more source

Injectable platelet-rich fibrin positively regulates osteogenic differentiation of stem cells from implant hole via the ERK1/2 pathway

Platelets, 2023
Bone regeneration in dentistry is a dynamic approach for treating critical size bone defects that are unlikely to self-heal. Human bone marrow stem cell (hBMSCs) therapies are being tested clinically for various disorders and have remarkable clinical ...
Jia Wang, Wanxin Li, Xuxia He, Simei Li, Hongwei Pan, Lihua Yin   +5 more
doaj   +1 more source

Metformin Ameliorates D-Galactose-Induced Senescent Human Bone Marrow-Derived Mesenchymal Stem Cells by Enhancing Autophagy

Stem Cells International, 2023
Human bone marrow-derived mesenchymal stem cells (hBMSCs) are promising candidates for stem cell therapy in clinical trials. Applications of hBMSCs in clinical therapy are limited by cellular senescence due to long-term ex vivo expansion.
Pingting Ye, Lei Feng, Dan Zhang, Ruihao Li, Yixuan Wen, Xiaohan Tong, Shuo Shi, Chunyan Dong   +7 more
doaj   +1 more source

KCNQ1OT1 regulates osteogenic differentiation of hBMSC by miR-320a/Smad5 axis.

European review for medical and pharmacological sciences, 2020
Osteogenic differentiation plays a crucial role in maintaining general bone homeostasis. Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) act as important regulators during the osteogenesis process. This study aimed to elucidate the mechanism of Potassium voltage-gated channel subfamily Q member 1 overlapping transcript 1 (KCNQ1OT1) in osteogenic ...
Wang, J.-L., Wei, X., Wang, A.-G., Bai, Y., Wu, X.-J.   +4 more
openaire   +2 more sources

Performance of mesenchymal cell-scaffold constructs in human oral reconstructive surgery: a systematic review [PDF]

, 2016
Background: Different sources of cultured cells combined with different scaffolds (allogenic, xenogeneic, alloplastic or composite materials) have been tested extensively in vitro and in preclinical animal studies, but there have been only a few ...
ANNIBALI, Susanna, Cristalli, Maria Paola, LA MONACA, Gerardo, MARINI, ROBERTA, Patini, Romeo, PRANNO, NICOLA   +5 more
core   +1 more source

Effects of Extracellular Vesicles from Osteogenic Differentiated Human BMSCs on Osteogenic and Adipogenic Differentiation Capacity of Naïve Human BMSCs

Cells, 2022
Osteoporosis, or steroid-induced osteonecrosis of the hip, is accompanied by increased bone marrow adipogenesis. Such a disorder of adipogenic/osteogenic differentiation, affecting bone-marrow-derived mesenchymal stem cells (BMSCs), contributes to bone ...
Chenglong Wang, Sabine Stöckl, Shushan Li, Marietta Herrmann, Christoph Lukas, Yvonne Reinders, Albert Sickmann, Susanne Grässel   +7 more
doaj   +1 more source

RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival

Cell Death and Disease, 2022
Molecular understanding of osteogenic differentiation (OD) of human bone marrow-derived mesenchymal stem cells (hBMSCs) is important for regenerative medicine and has direct implications for cancer.
Rostislav Novak, Yamen Abu Ahmad, Michael Timaner, Eliya Bitman-Lotan, Avital Oknin-Vaisman, Roi Horwitz, Oliver Hartmann, Michaela Reissland, Viktoria Buck, Mathias Rosenfeldt, David Nikomarov, Markus Elmar Diefenbacher, Yuval Shaked, Amir Orian   +13 more
doaj   +1 more source