Results 11 to 20 of about 7,514 (117)

Patterned Piezoelectric Scaffolds for Osteogenic Differentiation [PDF]

International Journal of Molecular Sciences, 2020
The morphological clues of scaffolds can determine cell behavior and, therefore, the patterning of electroactive polymers can be a suitable strategy for bone tissue engineering. In this way, this work reports on the influence of poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)) electroactive micropatterned scaffolds on the proliferation and ...
Teresa Marques-Almeida, Vanessa F. Cardoso, Miguel Gama, Senentxu Lanceros-Mendez, Clarisse Ribeiro   +4 more
openaire   +4 more sources

Osteogenic Activities of Trifolirhizin as a Bioactive Compound for the Differentiation of Osteogenic Cells

International Journal of Molecular Sciences, 2023
Plant extracts are widely used as traditional medicines. Sophora flavescens Aiton-derived natural compounds exert various beneficial effects, such as anti-inflammatory, anticancer, antioxidant, and antiregenerative activities, through their bioactive compounds, including flavonoids and alkaloids.
Hyung-Mun Yun, Mi Hyeon Cho, Hoibin Jeong, Soo Hyun Kim, Yun Hee Jeong, Kyung-Ran Park   +5 more
openaire   +2 more sources

The Regulatory Landscape of Osteogenic Differentiation [PDF]

Stem Cells, 2014
AbstractDifferentiation of osteoblasts from mesenchymal stem cells (MSCs) is an integral part of bone development and homeostasis, and may when improperly regulated cause disease such as bone cancer or osteoporosis. Using unbiased high-throughput methods we here characterize the landscape of global changes in gene expression, histone modifications, and
Anne-Mari, Håkelien, Jan Christian, Bryne, Kristine G, Harstad, Susanne, Lorenz, Jonas, Paulsen, Jinchang, Sun, Tarjei S, Mikkelsen, Ola, Myklebost, Leonardo A, Meza-Zepeda   +8 more
openaire   +2 more sources

Osteogenic Differentiation in Healthy and Pathological Conditions [PDF]

International Journal of Molecular Sciences, 2016
This review focuses on the osteogenic differentiation of mesenchymal stem cells (MSC), bone formation and turn-over in good and ill skeletal fates. The interacting molecular pathways which control bone remodeling in physiological conditions during a lifelong process are described.
VALENTI, Maria Teresa, DALLE CARBONARE, Luca Giuseppe, MOTTES, Monica   +2 more
openaire   +3 more sources

Bisindoylmaleimide I enhances osteogenic differentiation [PDF]

Protein & Cell, 2012
The Wnt/β-catenin and bone morphogenetic proteins (BMPs) pathways play important roles in controlling osteogenesis. Using a cell-based kinase inhibitor screening assay, we identified the compound bisindoylmaleimide I (BIM) as a potent agonist of the cytosolic β-catenin accumulation in preosteoblast cells. Through suppressing glycogen synthase kinase 3β
Zhou, F.F., Huang, H.Z., Zhang, L.
openaire   +3 more sources

Mtu1 defects are correlated with reduced osteogenic differentiation [PDF]

Cell Death & Disease, 2021
AbstractAccumulating evidence has revealed that mitochondria dynamics and function regulation is essential for the successful mesenchymal stem cell (MSC) differentiation. In the present study, the researchers reported for the first time that Mtu1 defects are correlated with reduced osteogenic differentiation.
Qiufen He, Qiong Zhao, Qianqian Li, Ruolang Pan, Xiongfeng Li, Ye Chen   +5 more
openaire   +3 more sources

Defective Osteogenic Differentiation in the Development of Osteosarcoma [PDF]

Sarcoma, 2011
Osteosarcoma (OS) is associated with poor prognosis due to its high incidence of metastasis and chemoresistance. It often arises in areas of rapid bone growth in long bones during the adolescent growth spurt. Although certain genetic conditions and alterations increase the risk of developing OS, the molecular pathogenesis is poorly understood. Recently,
Wagner, Eric R., Luther, Gaurav, Zhu, Gaohui, Luo, Qing, Shi, Qiong, Kim, Stephanie H., Gao, Jian-Li, Huang, Enyi, Gao, Yanhong, Yang, Ke, Wang, Linyuan, Teven, Chad, Luo, Xiaoji, Liu, Xing, Li, Mi, Hu, Ning, Su, Yuxi, Bi, Yang, He, Bai-Cheng, Tang, Ni, Luo, Jinyong, Chen, Liang, Zuo, Guowei, Rames, Richard, Haydon, Rex C., Luu, Hue H., He, Tong-Chuan   +26 more
openaire   +2 more sources

Dynamic and distinct histone modifications of osteogenic genes during osteogenic differentiation [PDF]

Journal of Biochemistry, 2015
Many skeletal diseases have common pathological phenotype of defective osteogenesis of bone marrow stromal cells (BMSCs), in which histone modifications play an important role. However, few studies have examined the dynamics of distinct histone modifications during osteogenesis. In this study, we examined the dynamics of H3K9/K14 and H4K12 acetylation;
Yong-Xing, Zhang, Hai-Lang, Sun, He, Liang, Kai, Li, Qi-Ming, Fan, Qing-Hua, Zhao   +5 more
openaire   +2 more sources

Mesenchymal stem cell-derived exosomes have altered microRNA profiles and induce osteogenic differentiation depending on the stage of differentiation. [PDF]

PLoS ONE, 2018
Human mesenchymal stem cell (hMSC)-derived exosomes have shown regenerative effects, but their role in osteogenesis and the underlying mechanism are yet to be determined.
Xiaoqin Wang, Omar Omar, Forugh Vazirisani, Peter Thomsen, Karin Ekström   +4 more
doaj   +1 more source

RUNX3 derived hsa_circ_0005752 accelerates the osteogenic differentiation of adipose-derived stem cells via the miR-496/MDM2-p53 pathway

Regenerative Therapy, 2021
Background: Circular RNAs (circRNAs) are non-coding RNAs that play a pivotal role in bone diseases. RUNX3 was an essential transcriptional regulator during osteogenesis.
Ming Wang, Yifan Huan, Xiyang Li, Jing Li, Guohua Lv   +4 more
doaj   +1 more source