Results 11 to 20 of about 91,170 (312)

circ-Iqsec1 induces bone marrow-derived mesenchymal stem cell (BMSC) osteogenic differentiation through the miR-187-3p/Satb2 signaling pathway

Arthritis Research & Therapy, 2022
Background Bone marrow-derived mesenchymal stem cells (BMSCs) are general progenitor cells of osteoblasts and adipocytes and they are characterized as a fundamental mediator for bone formation.
Lixia Fan, Kaiyun Yang, Ruixuan Yu, Houde Hui, Wenliang Wu   +4 more
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Lysophosphatidic acid induces proliferation and osteogenic differentiation of human dental pulp stem cell through lysophosphatidic acid receptor 3/extracellular signal-regulated kinase signaling axis

Journal of Dental Sciences, 2023
Background/purpose: Human dental pulp stem cells (hDPSCs) possess excellent proliferative and osteogenic differentiation potentials. This study aimed to elucidate the role of lysophosphatidic acid (LPA) signaling in the proliferation and osteogenic ...
Soon Chul Heo, Bo Ram Keum, Eun Jin Seo, Jinhwan Yoon, Sanghwa Jeong, Gabor J. Tigyi, Derek Norman, Il Ho Jang, Hyung Joon Kim   +8 more
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Bisindoylmaleimide I enhances osteogenic differentiation [PDF]

Protein & Cell, 2012
The Wnt/β-catenin and bone morphogenetic proteins (BMPs) pathways play important roles in controlling osteogenesis. Using a cell-based kinase inhibitor screening assay, we identified the compound bisindoylmaleimide I (BIM) as a potent agonist of the cytosolic β-catenin accumulation in preosteoblast cells. Through suppressing glycogen synthase kinase 3β
Zhou, F.F., Huang, H.Z., Zhang, L.
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Mtu1 defects are correlated with reduced osteogenic differentiation [PDF]

Cell Death & Disease, 2021
AbstractAccumulating evidence has revealed that mitochondria dynamics and function regulation is essential for the successful mesenchymal stem cell (MSC) differentiation. In the present study, the researchers reported for the first time that Mtu1 defects are correlated with reduced osteogenic differentiation.
Qiufen He, Qiong Zhao, Qianqian Li, Ruolang Pan, Xiongfeng Li, Ye Chen   +5 more
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Involvement of the long noncoding RNA H19 in osteogenic differentiation and bone regeneration

Stem Cell Research & Therapy, 2021
Osteogenic differentiation and bone regeneration are complex processes involving multiple genes and multiple steps. In this review, we summarize the effects of the long noncoding RNA (lncRNA) H19 on osteogenic differentiation.
Zimo Zhou, Mohammad Showkat Hossain, Da Liu   +2 more
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Mechanical Sensing Element PDLIM5 Promotes Osteogenesis of Human Fibroblasts by Affecting the Activity of Microfilaments

Biomolecules, 2021
Human skin fibroblasts (HSFs) approximate the multidirectional differentiation potential of mesenchymal stem cells, so they are often used in differentiation, cell cultures, and injury repair. They are an important seed source in the field of bone tissue
Xiaolan Huang, Rongmei Qu, Yan Peng, Yuchao Yang, Tingyu Fan, Bing Sun, Asmat Ullah Khan, Shutong Wu, Kuanhai Wei, Chujiang Xu, Jingxing Dai, Jun Ouyang, Shizhen Zhong   +12 more
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Probing Notch1-Dll4 signaling in regulating osteogenic differentiation of human mesenchymal stem cells using single cell nanobiosensor

Scientific Reports, 2022
Human mesenchymal stem cells (hMSCs) have great potential in cell-based therapies for tissue engineering and regenerative medicine due to their self-renewal and multipotent properties.
Yuwen Zhao, Rui Yang, Zoe Bousraou, Kiarra Richardson, Shue Wang   +4 more
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Defective Osteogenic Differentiation in the Development of Osteosarcoma [PDF]

Sarcoma, 2011
Osteosarcoma (OS) is associated with poor prognosis due to its high incidence of metastasis and chemoresistance. It often arises in areas of rapid bone growth in long bones during the adolescent growth spurt. Although certain genetic conditions and alterations increase the risk of developing OS, the molecular pathogenesis is poorly understood. Recently,
Wagner, Eric R., Luther, Gaurav, Zhu, Gaohui, Luo, Qing, Shi, Qiong, Kim, Stephanie H., Gao, Jian-Li, Huang, Enyi, Gao, Yanhong, Yang, Ke, Wang, Linyuan, Teven, Chad, Luo, Xiaoji, Liu, Xing, Li, Mi, Hu, Ning, Su, Yuxi, Bi, Yang, He, Bai-Cheng, Tang, Ni, Luo, Jinyong, Chen, Liang, Zuo, Guowei, Rames, Richard, Haydon, Rex C., Luu, Hue H., He, Tong-Chuan   +26 more
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MicroRNA treatment modulates osteogenic differentiation potential of mesenchymal stem cells derived from human chorion and placenta

Scientific Reports, 2021
Mesenchymal stem cells (MSCs) are important in regenerative medicine because of their potential for multi-differentiation. Bone marrow, chorion and placenta have all been suggested as potential sources for clinical application.
Kulisara Marupanthorn, Chairat Tantrawatpan, Pakpoom Kheolamai, Duangrat Tantikanlayaporn, Sirikul Manochantr   +4 more
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miR-637 Inhibits Osteogenic Differentiation of Human Intervertebral Disc Cartilage Endplate Stem Cells by Targeting WNT5A

Journal of Investigative Surgery, 2022
Background: Degenerative disk disease (DDD) remains the leading incentive of severe lumbago. DDD is mainly caused by degeneration of cartilage endplate (CEP).
Yunsheng Chen, Qin Chen, Mingliang Zhong, Canhua Xu, Yaohong Wu, Rongchun Chen   +5 more
doaj   +1 more source