Results 21 to 30 of about 85,126 (267)

Histone modifications centric-regulation in osteogenic differentiation [PDF]

Cell Death Discovery, 2021
AbstractHistone modification critically contributes to the epigenetic control of gene expression by changing the configuration of chromatin and modifying the access of transcription factors to gene promoters. Recently, we observed that histone acetylation and crotonylation mediated the expression of endocytosis-related genes and tumor-related immune ...
Kun Li, Jinxiang Han, Ziqiang Wang
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BRD4 facilitates osteogenic differentiation of human bone marrow mesenchymal stem cells through WNT4/NF-κB pathway

Journal of Orthopaedic Surgery and Research, 2023
Background Human bone marrow mesenchymal stem cells (hBMSCs) are a major source of osteoblast precursor cells and are directly involved in osteoporosis (OP) progression.
Tao Ning, Huihui Guo, Mingming Ma, Zhengang Zha   +3 more
doaj   +1 more source

Roles of SATB2 in Osteogenic Differentiation and Bone Regeneration [PDF]

Tissue Engineering Part A, 2011
Expressed in branchial arches and osteoblast-lineage cells, special AT-rich sequence-binding protein (SATB2) is responsible for preventing craniofacial abnormalities and defects in osteoblast function. In this study, we transduced SATB2 into murine adult stem cells, and found that SATB2 significantly increased expression levels of bone matrix proteins,
Zhang, J., Tu, Q., Grosschedl, R., Kim, M., Griffin, T., Drissi, H., Yang, P., Chen, J.   +7 more
openaire   +3 more sources

Expression of fibroblast growth factor receptor and its role in regulating osteoblast differentiation

Di-san junyi daxue xuebao, 2019
Objective To investigate the changes in the expression of fibroblast growth factor receptors 1-3 (FGFR1-3) at different stages of osteogenic differentiation and clarify the role of FGFR signaling in osteogenic differentiation.
MO Qifei, YANG Peng, SU Nan, CHEN Lin
doaj   +1 more source

RUNX3 derived hsa_circ_0005752 accelerates the osteogenic differentiation of adipose-derived stem cells via the miR-496/MDM2-p53 pathway

Regenerative Therapy, 2021
Background: Circular RNAs (circRNAs) are non-coding RNAs that play a pivotal role in bone diseases. RUNX3 was an essential transcriptional regulator during osteogenesis.
Ming Wang, Yifan Huan, Xiyang Li, Jing Li, Guohua Lv   +4 more
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Induction of Osteogenic Differentiation by Hedgehog Proteins

Biochemical and Biophysical Research Communications, 1997
In this study we asked whether members of the hedgehog gene family are involved in osteogenesis. C3H10T1/2 cells and MC3T3-E1 cells expressed the putative hedgehog receptor patched (Ptc) gene. Medium conditioned by chicken embryo fibroblast cultures expressing either Indian hedgehog or Sonic hedgehog stimulated alkaline phosphatase (APase) activity in ...
T, Nakamura, T, Aikawa, M, Iwamoto-Enomoto, M, Iwamoto, Y, Higuchi, M, Pacifici, N, Kinto, A, Yamaguchi, S, Noji, K, Kurisu, T, Matsuya, P, Maurizio   +11 more
openaire   +2 more sources

Osteogenic differentiation of fibroblast-like synovial cells in rheumatoid arthritis is induced by microRNA-218 through a ROBO/Slit pathway

Arthritis Research & Therapy, 2018
Background Fibroblast-like synovial cells (FLS) have multilineage differentiation potential including osteoblasts. We aimed to investigate the role of microRNAs during the osteogenic differentiation of rheumatoid arthritis (RA)-FLS.
Naoki Iwamoto, Shoichi Fukui, Ayuko Takatani, Toshimasa Shimizu, Masataka Umeda, Ayako Nishino, Takashi Igawa, Tomohiro Koga, Shin-ya Kawashiri, Kunihiro Ichinose, Mami Tmai, Hideki Nakamura, Tomoki Origuchi, Ko Chiba, Makoto Osaki, Astrid Jüngel, Steffen Gay, Atsushi Kawakami   +17 more
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Evaluation of Current Studies to Elucidate Processes in Dental Follicle Cells Driving Osteogenic Differentiation

Biomedicines, 2023
When research on osteogenic differentiation in dental follicle cells (DFCs) began, projects focused on bone morphogenetic protein (BMP) signaling. The BMP pathway induces the transcription factor DLX3, whichh in turn induces the BMP signaling pathway via
Christian Morsczeck, Michela De Pellegrin, Anja Reck, Torsten E. Reichert   +3 more
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Interleukin-6/interleukin-6 receptor complex promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells

Stem Cell Research & Therapy, 2018
Background Interleukin-6 (IL-6) with IL-6 receptor (IL-6R) play an important role in the tissue regeneration in vivo, especially bone metabolism. Bone marrow -derived mesenchymal stem cells (BM-MSCs) are multipotent stromal cells, which are main origin ...
Zhongyu Xie, Su’an Tang, Guiwen Ye, Peng Wang, Jinteng Li, Wenjie Liu, Ming Li, Shan Wang, Xiaohua Wu, Shuizhong Cen, Guan Zheng, Mengjun Ma, Yanfeng Wu, Huiyong Shen   +13 more
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Oral fibroblasts rescue osteogenic differentiation of mesenchymal stem cells after exposure to Zoledronic acid in a paracrine effect

Frontiers in Pharmacology, 2023
Background: Medication-related osteonecrosis of the jaw is a serious complication that develops in oncologic patients treated with Zoledronic acid. Although used for over 30 years, the influence of Zoledronic acid on bone has been thoroughly investigated,
Tal Berg, Tal Berg, Ofri Doppelt-Flikshtain, Ofri Doppelt-Flikshtain, Benjamin R. Coyac, Benjamin R. Coyac, Hadar Zigdon-Giladi, Hadar Zigdon-Giladi, Hadar Zigdon-Giladi   +8 more
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