Results 51 to 60 of about 7,514 (117)

NEAT1/microRNA 339-5p/SPI1 Axis Feedback Loop Contributes to Osteogenic Differentiation in Acute Suppurative Osteomyelitis in Children

Journal of Inflammation Research, 2023
Dongsheng Zhu,1,* Zhitao Zhu,2,* Han Qi3 1Department of Pediatric Surgery, the First People’s Hospital of Lianyungang, Affiliated to Xuzhou Medical University, Lianyungang, Jiangsu, 222000, People’s Republic of China; 2Department of Radiology ...
Zhu D, Zhu Z, Qi H
doaj  

The cannabinoid receptor I (CB1) enhanced the osteogenic differentiation of BMSCs by rescue impaired mitochondrial metabolism function under inflammatory condition

Stem Cell Research & Therapy, 2022
Background Periodontitis is a chronic infectious disease leading to bone resorption and periodontal tissue disruption under inflammatory stimulation.
Wanhao Yan, Le Li, Lihua Ge, Fengqiu Zhang, Zhipeng Fan, Lei Hu   +5 more
doaj   +1 more source

Alkaline Phosphatase-Mimicking Peptide Nanofibers for Osteogenic Differentiation [PDF]

Biomacromolecules, 2015
Recognition of molecules and regulation of extracellular matrix synthesis are some of the functions of enzymes in addition to their catalytic activity. While a diverse array of enzyme-like materials have been developed, these efforts have largely been confined to the imitation of the chemical structure and catalytic activity of the enzymes, and it is ...
Gulseren G., Yasa I.C., Ustahuseyin O., Tekin, E.D., Tekinay, A.B., Guler, M.O.   +5 more
openaire   +5 more sources

The epigenetic mechanism of mechanically induced osteogenic differentiation

Journal of Biomechanics, 2010
Epigenetic regulation of gene expression occurs due to alterations in chromatin proteins that do not change DNA sequence, but alter the chromatin architecture and the accessibility of genes, resulting in changes to gene expression that are preserved during cell division.
Arnsdorf, Emily J., Tummala, Padmaja, Castillo, Alesha B., Zhang, Fan, Jacobs, Christopher Rae   +4 more
openaire   +4 more sources

Enhanced Osteogenic Differentiation in Zoledronate-Treated Osteoporotic Patients [PDF]

International Journal of Molecular Sciences, 2017
Bisphosphonates are well known inhibitors of osteoclast activity and thus may be employed to influence osteoblast activity. The present study was designed to evaluate the in vivo effects of zoledronic acid (ZA) on the proliferation and osteoblastic commitment of mesenchymal stem cells (MSC) in osteoporotic patients.
DALLE CARBONARE, Luca Giuseppe, MOTTES, Monica, MALERBA, Giovanni, MORI, Antonio, Zaninotto, Martina, Plebani, Mario, Dellantonio, Alessandra, VALENTI, Maria Teresa   +7 more
openaire   +2 more sources

METTL3 promotes the osteogenic differentiation of periosteum-derived MSCs via regulation of the HOXD8/ITGA5 axis in congenital pseudarthrosis

Regenerative Therapy
Background: Congenital pseudarthrosis of the tibia (CPT) is a dominant health challenge in pediatric orthopedics. The essential process in the development of CPT is the limited capacity of mesenchymal stem cells (MSCs) derived from CPT to undergo ...
Weihua Ye, Zheng Liu, Yaoxi Liu, Han Xiao, Qian Tan, An Yan, Guanghui Zhu   +6 more
doaj   +1 more source

Knockdown of human-specific lncRNA MEK6-AS1 improves osteogenic differentiation of senescent mesenchymal stem cells [PDF]

Jichu yixue yu linchuang
Objective To investigate the role of a novel human-specific long noncoding RNA (lncRNA), MEK6-AS1, and its potential molecular mechanism in improving the osteogenic differentiation of senescent mesenchymal stem cells (MSCs).
CHEN Yunhua, LI Di, ZHAO Xiaoyan, CHEN Ming, LI Hongling, ZHAO Chunhua
doaj   +1 more source

Circular RNA GCLC promotes osteogenic differentiation of bone marrow mesenchymal stem cells via modulating miR-516b-5p/GNAS axis

Journal of Orthopaedic Surgery and Research
Objective Osteoporosis (OP) is a systemic bone disease without effective treatment at present. The aim of this study is to explore the role of the circular RNA GCLC (circGCLC) in the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs)
An Li, Sheng Zhang, Jing Zhang, Zhihua Peng, Qinghui Feng   +4 more
doaj   +1 more source

A roadmap of osteogenic differentiation in human mesenchymal stem cells assessed by protein multiplex analysis

European Cells & Materials
Human mesenchymal stem cells (hMSCs) are widely used to model osteogenic differentiation in vitro, yet few studies compare the numerous available protocols.
M Eischen-Loges, Z Tahmasebi Birgani, Y Alaoui Selsouli, L Eijssen, H Rho, M Sthijns, M van Griensven, V LaPointe, P Habibović   +8 more
doaj   +1 more source

Autophagy drives osteogenic differentiation of human gingival mesenchymal stem cells

Cell Communication and Signaling, 2019
Background/aim Autophagy is a macromolecular degradation process playing a pivotal role in the maintenance of stem-like features and in the morpho-functional remodeling of the tissues undergoing differentiation.
Chiara Vidoni, Alessandra Ferraresi, Eleonora Secomandi, Letizia Vallino, Chiara Gardin, Barbara Zavan, Carmen Mortellaro, Ciro Isidoro   +7 more
doaj   +1 more source