Results 51 to 60 of about 91,170 (312)

3D‐Printed Piezoionic/Bioelectronic Hydrogel for Electro‐Metabolic Regulation of Osteogenic Differentiation

Advanced Healthcare Materials, EarlyView.
A 3D‐printed piezoionic GPMx hydrogel enables stable electromechanical signal generation under mechanical loading, exhibiting long‐term durability and low fatigue. As a bioactive patch, it restores endogenous bioelectricity to stimulate osteogenesis via Ca2+ influx and mitochondrial activation, while simultaneously enabling label‐free alkaline ...
Sayan Deb Dutta, Myoung Joon Jeon, Youjin Seol, Ki‐Taek Lim   +3 more
wiley   +1 more source

Oncostatin M promotes osteogenic differentiation of tendon-derived stem cells through the JAK2/STAT3 signalling pathway

Journal of Orthopaedic Surgery and Research
Purpose Oncostatin M (OSM) is involved in the regulation of osteogenic differentiation and has a major role in the development of heterotopic ossification.
Jun Yang, Xiaolin Chen, Yueshu Wu, Gang Xu, Xiaochen Qu   +4 more
doaj   +1 more source

Vitamin D and Osteogenic Differentiation in the Artery Wall [PDF]

Clinical Journal of the American Society of Nephrology, 2008
Vascular calcification is widespread, particularly in patients with chronic kidney disease, who receive, among other treatments, active vitamin D supplements. Emerging evidence indicates that vascular calcification is a regulated process that resembles embryonic endochondral osteogenesis, involving osteoblastic differentiation of vascular smooth muscle
Jeffrey J, Hsu, Yin, Tintut, Linda L, Demer   +2 more
openaire   +2 more sources

Microgel‐Based 3D Bioprinting: A Convergent Strategy Integrating Material Design, Jamming Dynamics, and Biological Function

Advanced Healthcare Materials, EarlyView.
Microgel‐based 3D printed constructs represent a compelling and versatile innovation for engineering architecturally complex, dynamically remodelable, and biocompatible structures with high structural fidelity and bioactivity. By integrating material design, biofabrication, and biological function, these systems enable the development of adaptive ...
Elena Ghighină, Andreea Ioana Dinu, Jana Ghițman   +2 more
wiley   +1 more source

Notch signaling and fluid shear stress in regulating osteogenic differentiation

Frontiers in Bioengineering and Biotechnology, 2022
Osteoporosis is a common bone and metabolic disease that is characterized by bone density loss and microstructural degeneration. Human bone marrow-derived mesenchymal stem cells (hMSCs) are multipotent progenitor cells with the potential to differentiate
Yuwen Zhao, Yuwen Zhao, Kiarra Richardson, Kiarra Richardson, Rui Yang, Rui Yang, Zoe Bousraou, Yoo Kyoung Lee, Samantha Fasciano, Shue Wang   +9 more
doaj   +1 more source

Osteogenic differentiation of preosteoblasts on a hemostatic gelatin sponge [PDF]

Scientific Reports, 2016
AbstractBone tissue engineering provides many advantages for repairing skeletal defects. Although many different kinds of biomaterials have been used for bone tissue engineering, safety issues must be considered when using them in a clinical setting. In this study, we examined the effects of using a common clinical item, a hemostatic gelatin sponge, as
Zong-Keng Kuo, Po-Liang Lai, Elsie Khai-Woon Toh, Cheng-Hsi Weng, Hsiang-Wen Tseng, Pei-Zen Chang, Chih-Chen Chen, Chao-Min Cheng   +7 more
openaire   +2 more sources

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Multi-omics of in vitro aortic valve calcification

Frontiers in Cardiovascular Medicine, 2022
Heart valve calcification is an active cellular and molecular process that partly remains unknown. Osteogenic differentiation of valve interstitial cells (VIC) is a central mechanism in calcific aortic valve disease (CAVD).
Daria Semenova, Daria Semenova, Arsenii Zabirnyk, Arsenii Zabirnyk, Arseniy Lobov, Nadezda Boyarskaya, Olga Kachanova, Vladimir Uspensky, Bozhana Zainullina, Evgeny Denisov, Tatiana Gerashchenko, John-Peder Escobar Kvitting, John-Peder Escobar Kvitting, Mari-Liis Kaljusto, Bernd Thiede, Anna Kostareva, Kåre-Olav Stensløkken, Jarle Vaage, Jarle Vaage, Anna Malashicheva   +19 more
doaj   +1 more source

Double‐Transition‐Metal MXenes: Multimetallic 2D Platforms for Next‐Generation Biomedicine

Advanced Materials, EarlyView.
The present work explores recent progress in double‐transition‐metal MXenes and focuses on their potential as multifunctional biomedical nanoplatforms whose tunable optical, electronic, mechanical, and surface properties enable imaging, theranostics, antimicrobial activity, biosensing, tissue engineering, and drug delivery.
Parsa Namakiaraghi, Mohammad Mozafari, Masoud Soroush   +2 more
wiley   +1 more source