Results 61 to 70 of about 7,514 (117)

FOXG1 promotes osteogenesis of bone marrow-derived mesenchymal stem cells by activating autophagy through regulating USP14

Communications Biology
The osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) is key for bone formation, and its imbalance leads to osteoporosis.
Yiqi Zhang, Long Zhou, Qin Fu, Ziyun Liu
doaj   +1 more source

METTL3-Mediated m6A Modification Regulates the Osteogenic Differentiation through LncRNA CUTALP in Periodontal Mesenchymal Stem Cells of Periodontitis Patients

Stem Cells International
Objective. Periodontitis is a chronic inflammatory disease that causes loss of periodontal support tissue. Our objective was to investigate the mechanism by which METTL3-mediated N6-methyladenosine modification regulates the osteogenic differentiation ...
Xin Chen, Yuan Qin, Xian Wang, Hao Lei, Xiaochen Zhang, Houzhuo Luo, Changgang Guo, Weifu Sun, Shishu Fang, Wen Qin, Zuolin Jin   +10 more
doaj   +1 more source

CHD7 Regulates Osteogenic Differentiation of Human Dental Follicle Cells via PTH1R Signaling

Stem Cells International, 2020
Chromodomain helicase DNA-binding protein 7 (CHD7) is an ATP-dependent chromatin remodeling enzyme, functioning as chromatin reader to conduct epigenetic modification.
Caojie Liu, Qiwen Li, Qingyue Xiao, Ping Gong, Ning Kang   +4 more
doaj   +1 more source

Role of METTL16 in PPARγ methylation and osteogenic differentiation

Cell Death & Disease
Abstract Osteoporosis, a prevalent bone disease, is characterized by the deterioration of bone tissue microstructure and imbalanced osteogenesis. The regulatory role of PPARγ m6A methylation mediated by METTL16 remains poorly elucidated. This study utilized advanced single-cell RNA sequencing (scRNA-seq) and Bulk RNA-seq techniques to explore
Liangjie Lu, Lijun Wang, Minjie Yang, Huihan Wang   +3 more
openaire   +3 more sources

Comparison of osteogenic differentiation capacity in mesenchymal stem cells derived from human amniotic membrane (AM), umbilical cord (UC), chorionic membrane (CM), and decidua (DC)

Cell & Bioscience, 2019
Background Mesenchymal stem cells (MSCs) have been extensively explored as a promising therapeutic agent in the field of bone tissue engineering due to their osteogenic differentiation ability.
Chongyang Shen, Chuan Yang, Shijun Xu, Hai Zhao   +3 more
doaj   +1 more source

Nitrogen-containing bisphosphonate induces enhancement of OPG expression and inhibition of RANKL expression via inhibition of farnesyl pyrophosphate synthase to inhibit the osteogenic differentiation and calcification in vascular smooth muscle cells

BMC Cardiovascular Disorders
Background Nitrogen-containing bisphosphonate(N-BP)had been found to inhibit the osteogenic differentiation and calcification in vascular smooth muscle cells (VSMCs), but the mechanism is not clear.
Wei Xu, Lifeng Gong, Weigang Tang, Guoyuan Lu   +3 more
doaj   +1 more source

Grem1 inhibits osteogenic differentiation of MBMSCs in OVX rats through BMP/Smad1/5 signaling pathway

Regenerative Therapy
Objective: This study aims to explore how Grem1 regulates the differentiation and signaling activity of mandibular bone marrow mesenchymal stem cells (MBMSCs), affecting their osteogenic differentiation capacity and participating in the ...
Shan-shan Yang, Min LinHu, Xiao-hua Hu, Si-si Jiang, Wen-yue Hu, Xiao-hong Yang   +5 more
doaj   +1 more source

EIF4A3 enhances the viability, invasion and osteogenic differentiation of BMSCs via the USP53/SMAD5 pathway

Scientific Reports
SMAD5 has been demonstrated to promote osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) through the circ_0001825/miR-1270/SMAD5 axis or KCNQ1OT1/miR-320a/SMAD5 axis.
Gang Cheng, Xiaoling Yang, Yongtao Tang, Changjun Wu, Zulin Tang, Siqi Wei   +5 more
doaj   +1 more source

Cb1 Enhanced Osteogenic Differentiation Of Bmscs By Rescue Mitochondrial Metabolism

International Dental Journal
Aim or purpose: CB1 is the main effector of endogenous cannabinoid system, and our previous study verified CB1 enhanced the osteo/dentinogenic differentiation of dental mesenchymal stem cells (MSCs), which might be a target for alveolar bone regeneration.
Wanhao Yan
doaj   +1 more source

USP2-induced upregulation of LEF1 through deubiquitination relieves osteoporosis development by promoting the osteogenic differentiation of bone marrow mesenchymal stem cells

Journal of Orthopaedic Surgery and Research
Background Bone marrow mesenchymal stem cells (BMSCs) exhibit therapeutic potential for osteoporosis through their differentiation into osteoblasts. Here, we investigated the role and mechanism of lymphoid enhancer-binding factor 1 (LEF1) in regulating ...
Zhihong Zhang, Jie Cao, Hanwen Xing, Jing Liu, Linshuo Li, Yue Zhang   +5 more
doaj   +1 more source