Results 31 to 40 of about 148,190 (307)

The BMP Pathway and Its Inhibitors in the Skeleton.

Physiological Reviews, 2018
Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming growth factor-β family of ligands. BMPs exhibit widespread utility and pleiotropic, context-dependent effects, and the strength and duration of BMP pathway ...
J. Lowery, V. Rosen
semanticscholar   +1 more source

Interplay between BMPs and Reactive Oxygen Species in Cell Signaling and Pathology

Biomolecules, 2019
The integration of cell extrinsic and intrinsic signals is required to maintain appropriate cell physiology and homeostasis. Bone morphogenetic proteins (BMPs) are cytokines that belong to the transforming growth factor-β (TGF-β) superfamily ...
Cristina Sánchez-de-Diego, José Antonio Valer, Carolina Pimenta-Lopes, José Luis Rosa, Francesc Ventura   +4 more
doaj   +1 more source

The application of bone morphogenetic proteins in medicine, dentistry, sport and rehabilitation: A review of literature

Baltic Journal of Health and Physical Activity, 2020
Bone tissue is a mineralized structure with a complicated metabolism and due to its mechanical functions its structure must be adapted to the bone function.
ALEKSANDRA JARON, ELZBIETA GRZYWACZ, NATALIA KERBER-WYKA, SARA ZACHARSKA, MICHAL LOBACZ, GRZEGORZ TRYBEK   +5 more
doaj   +1 more source

Epicardial TGFβ and BMP Signaling in Cardiac Regeneration: What Lesson Can We Learn from the Developing Heart?

Biomolecules, 2020
The epicardium, the outer layer of the heart, has been of interest in cardiac research due to its vital role in the developing and diseased heart. During development, epicardial cells are active and supply cells and paracrine cues to the myocardium.
Esther Dronkers, Manon M.M. Wauters, Marie José Goumans, Anke M. Smits   +3 more
doaj   +1 more source

The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and disease

Cell Research
Transforming growth factor-βs (TGF-βs) and bone morphometric proteins (BMPs) belong to the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte lineage commitment and differentiation, skeletal development, and homeostasis ...
Mengrui Wu, Shali Wu, Wei Chen, Yi-Ping Li   +3 more
semanticscholar   +1 more source

TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling

Nature Communications, 2017
Heterozygous germ-line mutations in the bone morphogenetic protein type-II receptor (BMPR-II) gene underlie heritable pulmonary arterial hypertension (HPAH). Although inflammation promotes PAH, the mechanisms by which inflammation and BMPR-II dysfunction
L. Hurst, B. Dunmore, L. Long, A. Crosby, R. Al‐Lamki, J. Deighton, M. Southwood, Xudong Yang, M. Nikolić, B. Herrera, G. Inman, J. Bradley, A. Rana, P. Upton, N. Morrell   +14 more
semanticscholar   +1 more source

Bone Morphogenetic Protein (BMP) signaling in development and human diseases

Genes and Diseases, 2014
Bone Morphogenetic Proteins (BMPs) are a group of signaling molecules that belongs to the Transforming Growth Factor-β (TGF-β) superfamily of proteins.
Richard N. Wang, Jordan D. Green, Zhongliang Wang, You-Lin Deng, Min Qiao, Michael Peabody, Qian Zhang, Ji-Xing Ye, Zhengjian Yan, S. Denduluri, O. Idowu, Melissa Li, Christine Shen, A. Hu, R. Haydon, R. Kang, James Mok, Michael J. Lee, Hue L. Luu, Lewis L. Shi   +19 more
semanticscholar   +1 more source

BMP-9 interferes with liver regeneration and promotes liver fibrosis

Gut, 2017
Objective Bone morphogenetic protein (BMP)-9, a member of the transforming growth factor-β family of cytokines, is constitutively produced in the liver.
K. Breitkopf-Heinlein, C. Meyer, Courtney König, H. Gaitantzi, A. Addante, M. Thomas, E. Wiercinska, C. Cai, Qi Li, F. Wan, C. Hellerbrand, N. Valous, Maximilian Hahnel, C. Ehlting, J. Bode, Stephanie Müller-Bohl, U. Klingmüller, Jutta Altenöder, I. Ilkavets, M. Goumans, L. Hawinkels, Se-Jin Lee, M. Wieland, C. Mogler, M. Ebert, B. Herrera, H. Augustin, Aránzazu Sánchez, S. Dooley, P. ten Dijke   +29 more
semanticscholar   +1 more source

Biomechanical stress provides a second hit in the establishment of BMP/TGFβ-related vascular disorders

Cell Stress, 2020
Cardiovascular disorders are still the leading cause for mortality in the western world and challenge economies with steadily increasing healthcare costs.
Christian Hiepen, Jerome Jatzlau, Petra Knaus   +2 more
doaj   +1 more source

Function of BMPs and BMP Antagonists in Adult Bone

Annals of the New York Academy of Sciences, 2006
Abstract:  The expression and function of BMPs and BMPs in bone tissues have been studied for a long time because of their remarkable activities. However, their biological functions in normal bone remodeling in adults were not fully understood until recently. Advanced technologies using gene manipulation were used to study their roles in adulthood. In
openaire   +2 more sources