Results 51 to 60 of about 104,390 (258)

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

The self-limiting dynamics of TGF-β signaling in silico and in vitro, with negative feedback through PPM1A upregulation. [PDF]

PLoS Computational Biology, 2014
The TGF-β/Smad signaling system decreases its activity through strong negative regulation. Several molecular mechanisms of negative regulation have been published, but the relative impact of each mechanism on the overall system is unknown.
Junjie Wang, Lisa Tucker-Kellogg, Inn Chuan Ng, Ruirui Jia, P S Thiagarajan, Jacob K White, Hanry Yu   +6 more
doaj   +1 more source

Arl15 upregulates the TGFβ family signaling by promoting the assembly of the Smad-complex

eLife, 2022
The hallmark event of the canonical transforming growth factor β (TGFβ) family signaling is the assembly of the Smad-complex, consisting of the common Smad, Smad4, and phosphorylated receptor-regulated Smads.
Meng Shi, Hieng Chiong Tie, Mahajan Divyanshu, Xiuping Sun, Yan Zhou, Boon Kim Boh, Leah A Vardy, Lei Lu   +7 more
doaj   +1 more source

Biointegrated Battery‐Based Electroceuticals

Advanced Materials, EarlyView.
Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou, Zhilian Yue, Zhiqi Chen, Danming Chao, Xiaoteng Jia, Gordon Wallace, Caiyun Wang   +6 more
wiley   +1 more source

Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process. [PDF]

PLoS ONE, 2010
We have recently described that in an experimental model of atherosclerosis and in vascular smooth muscle cells (VSMCs) statins increased the activation of the Smad pathway by transforming growth factor-β (TGF-β), leading to an increase in TGF-β ...
Raúl Rodrigues Díez, Raquel Rodrigues-Díez, Carolina Lavoz, Sandra Rayego-Mateos, Esther Civantos, Juan Rodríguez-Vita, Sergio Mezzano, Alberto Ortiz, Jesús Egido, Marta Ruiz-Ortega, Marta Ruiz-Ortega   +10 more
doaj   +1 more source

Smad signalling network [PDF]

Journal of Cell Science, 2002
Dimeric ligands of the transforming growth factor β (TGF-β) superfamily bind with high affinity to type II and type I receptor serine/threonine kinases on the cell surface and induce hetero-tetrameric receptor complexes. In such complexes, constitutively auto-phosphorylated type II receptors (
openaire   +2 more sources

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical Applications

Diagnostics, 2023
Suppressor of mother against decapentaplegic (SMAD) family proteins are central to one of the most versatile cytokine signalling pathways in metazoan biology, the transforming growth factor-β (TGF-β) pathway.
Qi Wang, Fei Xiong, Guanhua Wu, Da Wang, Wenzheng Liu, Junsheng Chen, Yongqiang Qi, Bing Wang, Yongjun Chen   +8 more
doaj   +1 more source

Regulation of Smad Activity [PDF]

Cell, 2000
The Smads have emerged as a family of transcriptional comodulators that interact with a wide range of DNA-binding proteins to regulate their activity in response to TGFβ family signaling. Smad function in this regard is intimately linked to how much Smad is in the nucleus and this is subjected to extensive regulation both prior to and after activation ...
openaire   +2 more sources

Intravital Multimodal Imaging of Human Cortical Organoid Transplantation in a Mouse Model of Chronic Stroke

Advanced Science, EarlyView.
A multimodal intravital imaging platform enables longitudinal tracking of human cortical organoids transplanted into chronic stroke lesions. By combining surgical microscopy, MRI, bioluminescence imaging, and two‐photon fluorescence microscopy, the platform captures graft placement, viability dynamics, and cellular‐scale morphology in vivo, offering a ...
Jinghui Wang, Guanda Qiao, Honglin Tan, Colleen Russel, Baixuan Yang, Mengyang Jacky Li, Kexin Wang, Jiadi Xu, Chengyan Chu, Miroslaw Janowski, Tian‐Ming Fu, Piotr Walczak, Yajie Liang   +12 more
wiley   +1 more source