Results 1 to 10 of about 78,737 (162)
Activin‐A Regulates Bone Morphogenetic Protein Signaling in Pulmonary Endothelial Cells Without Affecting Bone Morphogenetic Protein Type‐II Receptor Expression [PDF]
Pulmonary CirculationActivin‐A is elevated in pulmonary arterial hypertension (PAH) patients, and reportedly suppresses BMPR‐II. This suggests one mechanism of action for PAH drug, sotatercept, an activin‐ligand trap. However, we were unable to confirm that activin‐A reduces
Benjamin J. Dunmore +4 more
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Assessment of serum levels of bone morphogenetic proteins as sensitive biomarkers for early prediction of acute myocardial infarction. [PDF]
Egyptian Journal of Pure and Applied Science, 2023 Although acute myocardial infarction (AMI) is a life-threatening disease, rapid diagnosis may reduce mortality risk. Despite being highly specific for AMI, cardiac troponin I (cTnI) does not distinguish between the etiologically diverse of myocardial ...
Fahmy Ali +5 more
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Increased BMP-Smad signaling does not affect net bone mass in long bones
Frontiers in Physiology, 2023 Bone morphogenetic proteins (BMPs) have been used for orthopedic and dental application due to their osteoinductive properties; however, substantial numbers of adverse reactions such as heterotopic bone formation, increased bone resorption and greater ...
Maiko Omi +5 more
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Bone Morphogenetic Proteins [PDF]
Cold Spring Harbor Perspectives in Biology, 2016 Bone morphogenetic proteins (BMPs), originally identified as osteoinductive components in extracts derived from bone, are now known to play important roles in a wide array of processes during formation and maintenance of various organs including bone, cartilage, muscle, kidney, and blood vessels. BMPs and the related "growth and differentiation factors"
Takenobu, Katagiri, Tetsuro, Watabe
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The biology of bone morphogenetic protein signaling pathway in cerebrovascular system
Chinese Neurosurgical Journal, 2021 Bone morphogenetic protein belongs to transcription growth factor superfamily β; bone morphogenetic protein signal pathway regulates cell proliferation, differentiation, and apoptosis among different tissues.
Haishuang Tang +10 more
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Heterodimeric BMP-2/7 antagonizes the inhibition of all-trans retinoic acid and promotes the osteoblastogenesis. [PDF]
PLoS ONE, 2013 OBJECTIVES: Hypervitaminosis A and alcoholism can result in a low mineral density and compromised regenerative capacity of bone, thus delaying implant osteointegration.
Wenjuan Bi +5 more
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Journal of Tissue Engineering, 2020 Limitation in cell sources for autologous cell therapy has been a recent focus in stem cell therapy and tissue engineering. Among various research advances, direct conversion, or transdifferentiation, is a notable and feasible strategy for the generation
Seung Hyun L Kim +8 more
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The Classic: Bone Morphogenetic Protein [PDF]
Clinical Orthopaedics and Related Research®, 2009 This Classic Article is a reprint of the original work by Marshall R. Urist and Basil S. Strates, Bone Morphogenetic Protein. An accompanying biographical sketch of Marshall R. Urist, MD is available at DOI 10.1007/s11999-009-1067-4; a second Classic Article is available at DOI 10.1007/s11999-009-1069-2; and a third Classic Article is available at DOI ...
Urist, Marshall R., Strates, Basil S.
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Functional analysis of alleged NOGGIN mutation G92E disproves its pathogenic relevance.
PLoS ONE, 2012 We identified an amino acid change (p.G92E) in the Bone Morphogenetic Protein antagonist NOGGIN in a 22-month-old boy who presented with a unilateral brachydactyly type B phenotype. Brachydactyly type B is a skeletal malformation that has been associated
Julia Zimmer +6 more
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Bone Morphogenetic Protein-2 in Development and Bone Homeostasis
Journal of Developmental Biology, 2020 Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the Transforming Growth Factor-Beta (TGF-β) superfamily. These proteins are essential to many developmental processes, including cardiogenesis, neurogenesis, and ...
Daniel Halloran +2 more
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