Results 1 to 10 of about 88,042,096 (284)

The serum levels of activin A and bone morphogenetic protein-4 and -6 in patients with fibrodysplasia ossificans progressiva. [PDF]

Orphanet J Rare Dis, 2023
Background Fibrodysplasia ossificans progressiva (FOP) is an ultrarare and disabling genetic disorder of connective tissue characterized by congenital malformation of the great toes, and progressive heterotopic ossification (HO) in soft connective ...
Ye Z, Wang S, Shan C, Zhu Q, Xue Y, Zhang K.   +5 more
europepmc   +2 more sources

Bone morphogenetic protein 4 in perivascular adipose tissue ameliorates hypertension through regulation of angiotensinogen. [PDF]

Front Cardiovasc Med, 2022
BackgroundPerivascular adipose tissue (PVAT), an active endocrine organ, exerts direct effect on vascular tone through paracrine. Activation of PVAT metabolism plays an inhibitory role in atherosclerosis via secreting relaxing factors.
Mu WJ, Song YJ, Yang LJ, Qian SW, Yang QQ, Liu Y, Tang QQ, Tang Y.   +7 more
europepmc   +2 more sources

Bone morphogenetic protein 4 alleviates nonalcoholic steatohepatitis by inhibiting hepatic ferroptosis. [PDF]

Cell Death Discov, 2022
Nonalcoholic steatohepatitis (NASH) is a state of simple steatosis that progresses to inflammation and liver injury accompanied by ferroptosis. Bone morphogenetic protein 4 (BMP4) plays an important role in adipogenesis and differentiation, as well as in
Wang X, Ma B, Wen X, You H, Sheng C, Bu L, Qu S.   +6 more
europepmc   +2 more sources

The Role of Bone Morphogenetic Protein 4 in Microglial Polarization in the Process of Neuropathic Pain. [PDF]

J Inflamm Res, 2022
Changqing Liu,1,2,* Qi Sun,1,2,* Junmei Xu,1,2 Weiyun Shen,1,2 Hui Li,1,2 Lin Yang1,2 1Department of Anesthesiology, Second Xiangya Hospital, Central South University, Changsha, Hunan Province, People’s Republic of China; 2Hunan Province Center ...
Liu C, Sun Q, Xu J, Shen W, Li H, Yang L.   +5 more
europepmc   +2 more sources

Bone morphogenetic protein 4-associated mitochondrial dysfunction in diabetic nephropathy involves Parkin downregulation. [PDF]

Front Clin Diabetes Healthc
BackgroundDiabetic nephropathy (DN) is characterized by mesangial expansion and mitochondrial dysfunction. Although bone morphogenetic protein 4 (BMP4) is a pro-fibrotic factor in DN, its role in mesangial mitochondrial homeostasis remains unclear.
Tamaki M, Tominaga T, Hasegawa K, Kida T, Miyakami S, Shimizu I, Yamaguchi S, Minato M, Nagai K, Wakino S.   +9 more
europepmc   +2 more sources

Platelet Bone Morphogenetic Protein-4 Mediates Vascular Inflammation and Neointima Formation after Arterial Injury. [PDF]

Cells, 2021
The purpose of this study is to investigate the role of platelet bone morphogenetic proteins (BMP)-4 during vascular inflammation and remodeling in a mouse model of carotid wire injury. Transgenic mice with a platelet-specific deletion of BMP-4 (BMP4Plt−/
Jank M, von Niessen N, Olivier CB, Schmitt H, Anto-Michel N, Hilgendorf I, Bode C, Moser M, Esser JS, Zhou Q.   +9 more
europepmc   +2 more sources

Bone Morphogenetic Protein 4 Alleviates DSS-Induced Ulcerative Colitis Through Activating Intestinal Stem Cell by Target ID3. [PDF]

Front Cell Dev Biol, 2021
Damage to intestinal epithelial cell proliferation or intestinal stem cell (ISC) maintenance may trigger inflammatory bowel disease (IBD), and protecting the ISCs is critical for IBD treatment.
Hu L, Xu J, Wang X, Feng L, Zhang C, Wang J, Wang S.   +6 more
europepmc   +2 more sources

Correction: Bone morphogenetic protein 4 alleviates nonalcoholic steatohepatitis by inhibiting hepatic ferroptosis. [PDF]

Cell Death Discov, 2022
Wang X, Ma B, Wen X, You H, Sheng C, Bu L, Qu S.   +6 more
europepmc   +2 more sources

Matrix Gla protein maintains normal and malignant hematopoietic progenitor cells by interacting with bone morphogenetic protein-4. [PDF]

Heliyon, 2020
Matrix Gla protein (MGP), a modulator of the BMP-SMAD signals, inhibits arterial calcification in a Glu γ-carboxylation dependent manner but the role of MGP highly expressed in a subset of bone marrow (BM) mesenchymal stem/stromal cells is unknown.
Kuronuma K, Yokoi A, Fukuoka T, Miyata M, Maekawa A, Tanaka S, Matsubara L, Goto C, Matsuo M, Han HW, Tsuruta M, Murata H, Okamoto H, Hasegawa N, Asano S, Ito M.   +15 more
europepmc   +2 more sources

Bone Morphogenetic Protein 4 Gene Therapy in Mice Inhibits Myeloma Tumor Growth, But Has a Negative Impact on Bone. [PDF]

JBMR Plus, 2020
Multiple myeloma is characterized by accumulation of malignant plasma cells in the bone marrow. Most patients suffer from an osteolytic bone disease, caused by increased bone degradation and reduced bone formation.
Westhrin M, Holien T, Zahoor M, Moen SH, Buene G, Størdal B, Hella H, Yuan H, de Bruijn JD, Martens A, Groen RW, Bosch F, Smith U, Sponaas AM, Sundan A, Standal T.   +15 more
europepmc   +2 more sources