Frontiers in Cellular NeuroscienceBone morphogenetic protein-4 (BMP4) is involved in regulation of neural stem cells (NSCs) proliferation, differentiation, migration and survival. It was previously thought that the treatment of NSCs with BMP4 alone induces astrocytes, whereas the ...
Siguang Li, Chenming Liu, Yuping Luo
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The prodomain of BMP4 is necessary and sufficient to generate stable BMP4/7 heterodimers with enhanced bioactivity in vivo [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance Bone morphogenetic proteins (BMPs) are made as inactive precursor proteins that dimerize and are cleaved to generate a bioactive ligand along with prodomain fragments that lack signaling activity. BMP ligands signal as either homodimers, or as heterodimers that display significantly higher activity in vivo.
Nathan Donley +2 more
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BMP4 Cross-talks With Estrogen/ERα Signaling to Regulate Adiposity and Glucose Metabolism in Females
EBioMedicine, 2016 Similar to estrogens, bone morphogenetic protein 4 (BMP4) promotes the accumulation of more metabolically active subcutaneous fat and reduction of visceral fat.
Liang Guo, Qi-Qun Tang, Xi Li
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BMP4 dose dictates lineage specification bias in human periodontal ligament stem cells [PDF]
Frontiers in Bioengineering and BiotechnologyIntroductionPeriodontal ligament stem cells (PDLSCs) represent a promising therapeutic cell source for regenerating periodontal tissues impaired by disease.
Yihong Li +9 more
doaj +2 more sources
Comprehensive analyses of single-cell and bulk RNA-seq reveal the biological and prognostic roles of BMP4 in pancreatic adenocarcinoma [PDF]
Frontiers in Molecular BiosciencesBone Morphogenetic Protein 4 (BMP4) plays a critical role in development, but its function in pancreatic adenocarcinoma (PAAD) is not well understood.
Ao Wang +11 more
doaj +2 more sources
Synapse Elimination Triggered by BMP4 Exocytosis and Presynaptic BMP Receptor Activation
Cell Reports, 2018 In vitro screening of signaling molecules involved in neural circuit formation has identified a large number of synaptogenic proteins. However, factors that drive synapse elimination remain elusive. Here, we report that bone morphogenetic protein 4 (BMP4)
Shigeo Okabe
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Differentiation of human endometrial stem cells encapsulated in alginate hydrogel into oocyte-like cells [PDF]
BioImpacts, 2023 Introduction: Human endometrial mesenchymal stem cells (hEnMSCs) are a rich source of mesenchymal stem cells (MSCs) with multi-lineage differentiation potential, making them an intriguing tool in regenerative medicine, particularly for the treatment of ...
Diba Ghasemi +10 more
doaj +1 more source
Small molecule-induced destabilization of β-catenin and RAS is the ideal strategies for suppressing colorectal cancer [PDF]
Organoid, 2023 Background Mutations of adenomatous polyposis coli (APC) and KRAS play essential roles in the development of colorectal cancer (CRC) by forming an abnormal colon morphology.
Yonghyo Kim +3 more
doaj +1 more source
Expression of BMP-4 in dentigerous cyst and ameloblastoma: Is it a differentiation measure?
European Oral Research, 2022 Purpose: This study aimed to determine the expression of Bone Morphogenic Protein-4 (BMP 4) in dentigerous cyst (DC), unicystic-ameloblastoma (UA), and Multicystic-ameloblastoma (MA), and assess whether this marker can be a differentiation measure ...
Soudabeh Sargolzaei +2 more
doaj +1 more source
Effects of Treatment with Bone Morphogenetic Protein 4 and Co-culture on Expression of Piwil2 Gene in Mouse Differentiated Embryonic Stem Cells [PDF]
International Journal of Fertility and Sterility, 2009 Background Specific growth factors and feeder layers seem to have important roles in in vitro embryonic stem cells (ESCs) differentiation. In this study,the effects of bone morphogenetic protein 4 (BMP4) and mouse embryonic fibroblasts (MEFs) co-culture ...
Zohreh Makoolati +2 more
doaj +1 more source