Results 31 to 40 of about 32,745 (240)
Cells, 2023 Bone Morphogenetic Protein 4 (BMP4) is a secreted growth factor of the Transforming Growth Factor beta (TGFβ) superfamily. The goal of this study was to test whether BMP4 contributes to the pathogenesis of diabetic retinopathy (DR). Immunofluorescence of
Noureldien H. E. Darwish +7 more
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Functional Concentrations of BMP4 on Differentiation of Mouse Embryonic Stem Cells to Primordial Germ Cells [PDF]
International Journal of Fertility and Sterility, 2011 Background Bone morphogenetic protein 4 (BMP4) has a significant role in primordial germ cells (PGCs) differentiation from mouse embryonic stem cell (mESC).
Hatef Ghasemi Hamidabadi +5 more
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Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation
eLife, 2020 During endoplasmic reticulum-associated degradation (ERAD), the cytoplasmic enzyme N -glycanase 1 (NGLY1) is proposed to remove N -glycans from misfolded N -glycoproteins after their retrotranslocation from the ER
Antonio Galeone +13 more
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BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer’s disease
Cell Death Discovery, 2021 Alzheimer’s disease (AD) is a chronic progressive degenerative disease of the nervous system. Its pathogenesis is complex and is related to the abnormal expression of the amyloid β (Aβ), APP, and Tau proteins.
Xiaoqing Zhang +8 more
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BMP4 expression in the developing rat retina
Brain Research, 2006 We investigated the expression of bone morphogenetic protein-4 (BMP4) in the developing retina. At E19, we found very intense BMP4 immunoreactivity (IR) in the nerve fiber layer. At P1, the inner plexiform layer exhibited very strong BMP4-IR. Thereafter, abundant BMP4 expression was kept to the adult period.
Yuka, Maruyama +3 more
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BMP4 regulation of human trophoblast development
The International Journal of Developmental Biology, 2014 Since the derivation of human embryonic stem cells, and the subsequent generation of induced pluripotent stem cells, there has been much excitement about the ability to model and evaluate human organ development in vitro. The finding that these cells, when treated with BMP4, are able to generate the extraembryonic cell type, trophoblast, which is the ...
Li, Yingchun, Parast, Mana M
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, 2011 (A) Addition of BMP4 (open symbols) results in an increase in the number of colonies produced at 10·5 dpc compared with serum-free conditions (−BMP4, solid symbols).
Joanna C Sinclair (91388) +3 more
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Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia. [PDF]
PLoS ONE, 2010 Bone marrow erythropoiesis is primarily homeostatic, producing new erythrocytes at a constant rate. However at times of acute anemia, new erythrocytes must be rapidly produced much faster than bone marrow steady state erythropoiesis.
Dai-Chen Wu, Robert F Paulson
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Determining the function of nuclear Bmp4
The FASEB Journal, 2009 Bone morphogenetic protein 4 (Bmp4) is a well known growth factor that regulates gene expression through the SMAD signaling pathway. Bmp4 is involved in many developmental processes and has been identified as an important factor in several cancers, including melanoma, ovarian cancer, and colon cancer ...
Trina J Loos, Laura C Bridgewater
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JBMR Plus, 2020 Multiple myeloma is characterized by accumulation of malignant plasma cells in the bone marrow. Most patients suffer from an osteolytic bone disease, caused by increased bone degradation and reduced bone formation.
Marita Westhrin +15 more
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