Results 31 to 40 of about 26,444 (201)

Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation

eLife, 2020
During endoplasmic reticulum-associated degradation (ERAD), the cytoplasmic enzyme N -glycanase 1 (NGLY1) is proposed to remove N -glycans from misfolded N -glycoproteins after their retrotranslocation from the ER
Antonio Galeone, Joshua M Adams, Shinya Matsuda, Maximiliano F Presa, Ashutosh Pandey, Seung Yeop Han, Yuriko Tachida, Hiroto Hirayama, Thomas Vaccari, Tadashi Suzuki, Cathleen M Lutz, Markus Affolter, Aamir Zuberi, Hamed Jafar-Nejad   +13 more
openaire   +6 more sources

Bone Morphogenetic Protein 4 Gene Therapy in Mice Inhibits Myeloma Tumor Growth, But Has a Negative Impact on Bone

JBMR Plus, 2020
Multiple myeloma is characterized by accumulation of malignant plasma cells in the bone marrow. Most patients suffer from an osteolytic bone disease, caused by increased bone degradation and reduced bone formation.
Marita Westhrin, Toril Holien, Muhammad Zahoor, Siv Helen Moen, Glenn Buene, Berit Størdal, Hanne Hella, Huipin Yuan, Joost D deBruijn, Anton Martens, Richard WJ Groen, Fatima Bosch, Ulf Smith, Anne‐Marit Sponaas, Anders Sundan, Therese Standal   +15 more
doaj   +1 more source

BMP4 regulation of human trophoblast development

The International Journal of Developmental Biology, 2014
Since the derivation of human embryonic stem cells, and the subsequent generation of induced pluripotent stem cells, there has been much excitement about the ability to model and evaluate human organ development in vitro. The finding that these cells, when treated with BMP4, are able to generate the extraembryonic cell type, trophoblast, which is the ...
Li, Yingchun, Parast, Mana M
openaire   +5 more sources

BMP4 promotes hepatocellular carcinoma proliferation by autophagy activation through JNK1-mediated Bcl-2 phosphorylation

Journal of Experimental & Clinical Cancer Research, 2018
Background Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, plays a crucial role in human ...
Ganlu Deng, Shan Zeng, Yanling Qu, Qingqing Luo, Cao Guo, Ling Yin, Ying Han, Yiyi Li, Changjing Cai, Yaojie Fu, Hong Shen   +10 more
doaj   +1 more source

Determining the function of nuclear Bmp4

The FASEB Journal, 2009
Bone morphogenetic protein 4 (Bmp4) is a well known growth factor that regulates gene expression through the SMAD signaling pathway. Bmp4 is involved in many developmental processes and has been identified as an important factor in several cancers, including melanoma, ovarian cancer, and colon cancer ...
Trina J Loos, Laura C Bridgewater
openaire   +1 more source

Bone morphogenetic protein 4 regulates immortalized chicken preadipocyte proliferation by promoting G1/S cell cycle progression

FEBS Open Bio, 2019
Bone morphogenetic protein 4 (BMP4) has been reported to regulate adipose development, but its role in preadipocyte proliferation has not been explored in vitro.
Hongyan Chen, Chang Liu, Chong Chen, Zhiyong Su, Jingting Shu, Ming Zhang, Hui Li, Bohan Cheng   +7 more
doaj   +1 more source

BMP suppresses WNT to integrate patterning of orthogonal body axes in adult planarians.

PLoS Genetics, 2023
Adult regeneration restores patterning of orthogonal body axes after damage in a post-embryonic context. Planarians regenerate using distinct body-wide signals primarily regulating each axis dimension: anteroposterior Wnts, dorsoventral BMP, and ...
Eleanor G Clark, Christian P Petersen
doaj   +1 more source

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

A new function of BMP4: dual role for BMP4 in regulation ofSonic hedgehogexpression in the mouse tooth germ [PDF]

Development, 2000
ABSTRACTThe murine tooth development is governed by sequential and reciprocal epithelial-mesenchymal interactions. Multiple signaling molecules are expressed in the developing tooth germ and interact each other to mediate the inductive tissue interactions.
Y, Zhang, Z, Zhang, X, Zhao, X, Yu, Y, Hu, B, Geronimo, S H, Fromm, Y P, Chen   +7 more
openaire   +2 more sources

BMP4 Signaling Is Able to Induce an Epithelial-Mesenchymal Transition-Like Phenotype in Barrett's Esophagus and Esophageal Adenocarcinoma through Induction of SNAIL2.

PLoS ONE, 2016
BackgroundBone morphogenetic protein 4 (BMP4) signaling is involved in the development of Barrett's esophagus (BE), a precursor of esophageal adenocarcinoma (EAC).
Christine Kestens, Peter D Siersema, G Johan A Offerhaus, Jantine W P M van Baal   +3 more
doaj   +1 more source