Results 51 to 60 of about 32,745 (240)

Simulate BMP4 Dynamics

, 2019
C code for simulating BMP4 dynamics in early mouse embryo, and studying the effect of embryo geometry and receptor localization on BMP4 ...
Zhechun Zhang (7276958)
core   +1 more source

Guanosine‐Quadruplex Hydrogels as Dynamic, Mechanically Tunable and Ion Conductive 3D Scaffolds for Cell Culture Applications

Advanced Functional Materials, EarlyView.
Versatile guanosine‐quadruplex (GQ) hydrogels are developed as dynamic biomatrices for cell culture. These scaffolds are fabricated under mild aqueous conditions, present improved stability, tunable mechanical properties within physiological ranges; fibrillar, porous microstructure, ion conductivity, and cytocompatibility.
Neha Thakur, Minye Jin, Pavel Milkin, Deepa Negi, Carla Cofiño Fabres, Hubert Gojzewski, Leonid Ionov, Alla Synytska, Andries van der Meer, Robert Passier, Julieta I. Paez   +10 more
wiley   +1 more source

Developmental expression of BMP4/ALK3/SMAD5 signaling pathway in the mouse testis: a potential role of BMP4 in spermatogonia differentiation [PDF]

Journal of Cell Science, 2003
It is well established that the c-kit gene plays an essential role in the proliferation of differentiating spermatogonia in prepuberal mice. However, the mechanisms that regulate the onset of spermatogenesis, i.e. differentiation of spermatogonial stem cells and c-kit expression,are poorly understood. Here we identify a novel signal transduction system
Pellegrini, M, GRIMALDI, PAOLA, ROSSI, PELLEGRINO, GEREMIA, RAFFAELE, DOLCI IANNINI, SUSANNA   +4 more
openaire   +5 more sources

wnt5 co-inhibition does not rescue the bmp4(RNAi) phenotype of reduced slit expression.

, 2023
FISH staining for slit following 20 days of control, bmp4, wnt5, and bmp4;wnt5 RNAi. Loss of bmp4 reduces slit expression (arrows). Loss of wnt5 did not appear to alter slit expression.
Eleanor G. Clark (17015069), Christian P. Petersen (7517978)   +1 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Functional analysis of BMP4 mutations identified in pediatric CAKUT patients

, 2009
Human congenital anomalies of the kidney and urinary tract (CAKUT) represent the major causes of chronic renal failure (CRF) in children. This set of disorders comprises renal agenesis, hypoplasia, dysplastic or double kidneys, and/or malformations of ...
Karl-Peter Schlingmann, Aysin Bakkaloglu, Weber, S, Schaefer, Franz, Sevinc Emre, Emre, S, Mieczyslaw Litwin, Weber, Stefanie, Emre, Sevinc, Stefanie Weber, Mehls, Otto, Schlingmann, Karl-Peter, Otto Mehls, Tabatabaeifar, Mansoureh, Corinne Antignac, Franz Schaefer, Schlingmann, K-P, Tabatabaeifar, M, ESCAPE, Trial Group, Schaefer, F, Bakkaloglu, Aysin, Bakkaloglu, A, Litwin, Mieczyslaw, Mehls, O, Mansoureh Tabatabaeifar, Antignac, Corinne, Antignac, C, Litwin, M   +27 more
core   +1 more source

BMP4 Signaling Is Able to Induce an Epithelial-Mesenchymal Transition-Like Phenotype in Barrett's Esophagus and Esophageal Adenocarcinoma through Induction of SNAIL2.

PLoS ONE, 2016
BackgroundBone morphogenetic protein 4 (BMP4) signaling is involved in the development of Barrett's esophagus (BE), a precursor of esophageal adenocarcinoma (EAC).
Christine Kestens, Peter D Siersema, G Johan A Offerhaus, Jantine W P M van Baal   +3 more
doaj   +1 more source

BMP suppresses WNT to integrate patterning of orthogonal body axes in adult planarians.

PLoS Genetics, 2023
Adult regeneration restores patterning of orthogonal body axes after damage in a post-embryonic context. Planarians regenerate using distinct body-wide signals primarily regulating each axis dimension: anteroposterior Wnts, dorsoventral BMP, and ...
Eleanor G Clark, Christian P Petersen
doaj   +1 more source

Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction

Advanced Science, EarlyView.
In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng, Qian Zhu, Yusong Wang, Hao Rong, Xu Zhang, Fuchun Wang, Tianqi Yu, Wenxuan Wang, Jing Li, Lei Tian, Menghui Liao, Renjie Chai, Yangnan Hu   +12 more
wiley   +1 more source

BMP4 is a novel paracrine inhibitor of liver regeneration

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2012
Transforming growth factor (TGF)-β family members exert strong effects on restoration of liver mass after injury. Bone morphogenetic proteins (BMPs) are members of the TGF-β family and are found in the liver, suggesting that these proteins may play a role in liver regeneration. We examined BMP signaling in the liver during hepatectomy.
Nhue, Do, Rong, Zhao, Kevin, Ray, Karen, Ho, Martin, Dib, Xianghui, Ren, Paula, Kuzontkoski, Ernest, Terwilliger, Seth J, Karp   +8 more
openaire   +3 more sources