Results 71 to 80 of about 32,745 (240)

Bone morphogenetic protein 4 inhibits rat stem/progenitor Leydig cell development and regeneration via SMAD-dependent and SMAD-independent signaling

Cell Death and Disease, 2022
Bone morphogenetic protein 4 (BMP4) is an important member of the transforming growth factor-β superfamily. BMP4 is expressed in the Leydig cell lineage. We hypothesized that BMP4 might regulate the development of stem/progenitor Leydig cells.
Xiaoheng Li, Yinghui Fang, Lanlan Chen, Hehua Quan, Yiyan Wang, Ren-Shan Ge   +5 more
doaj   +1 more source

Notch signaling-mediated osteocytic overexpression of BMP4 promotes osteogenic differentiation of bone marrow stromal cells

Di-san junyi daxue xuebao, 2021
Objective To investigate the effect of bone morphogenetic protein 4 (BMP4) overexpression in MLO-Y4 osteocytes on osteogenic differentiation of bone marrow stromal ST2 cells through Notch signaling. Methods Ad-GFP or Ad-BMP4 infected MLO-Y4 cells were co-
XIE Zhengsong, ZHAO Yixin, LYU Ziling, LIU Hong, TU Xiaolin   +4 more
doaj   +1 more source

Mapping Embryonic Mouse Lung Development Using Enhanced Spatial Transcriptomics

Advanced Science, EarlyView.
The mammalian lung contains ∼50 cell types arranged along the airway epithelium. Here, deterministic barcoding sequencing (DBiT‐seq) is optimized to nearly double transcript recovery, enabling highly sensitive spatial mapping of the embryonic mouse lung.
Pengfei Zhang, Benjamin K. Law, Niles Huang, Katharine Goodwin, Celeste M. Nelson, Michelle M. Chan   +5 more
wiley   +1 more source

NOX4 knockdown decreased TRPC1 and TRPC6 expression under both control and BMP4 treatment circumstances.

, 2014
A: Western blot analysis of TRPC1 protein after knockout of NOX4 in rat distal PASMCs, of which the upper band is TRPC1, the following band is α-actin; NC and NOX4 siRNA group indicate negative control group and NOX4 knockout group respectively.
Wenju Lu (430078), Kai Yang (73590), Lichun Tian (320047), Jie Zhang (64655), Yuqin Chen (627602), Xiuqing Chen (627603), Jian Wang (5901), Xin Fu (448766), Qian Jiang (216582)   +8 more
core   +1 more source

Study of the association between the BMP4 gene and congenital anomalies of the kidney and urinary tract

Jornal de Pediatria, 2014
OBJECTIVE: To determine the frequency of different phenotypes for congenital anomalies of the kidney and urinary tract (CAKUT) in a Brazilian sample, and to evaluate the association between the CAKUT phenotypes and the BMP4 gene.
Geisilaine Soares dos Reis, Ana Cristina Simoes e Silva, Izabella Silva Freitas, Thiago Ramos Heilbuth, Luiz Armando de Marco, Eduardo Araujo Oliveira, Debora Marques Miranda   +6 more
doaj   +3 more sources

A General High‐Throughput Mucus Microrheology Platform for Quantitative and Scalable Mucus Phenotyping

Advanced Science, EarlyView.
High‐throughput Differential Dynamic Microscopy measures frequency‐resolved mechanical fingerprints from 3 to 10 μL$\umu{\rm L}$ mucus samples using only a few minutes of operator attention per sample. This automated analysis enables scalable mucus phenotyping for translational research by distinguishing mechanical heterogeneity among donors, disease ...
Feng Ling, Ayşe Tuğçe Şahin, Bernardo Miller Naranjo, Stefano Aime, Doris Roth, Anna Pukaluk, Niels Tepho, Romina Augustin, Benedetta Zampa, Andrea S. Vendrame, Mark‐Christian Klassen, Ellen Emken, Marion Kiechle, Mircea Gabriel Stoleriu, Pontus Mertsch, Ruth Olmer, Yohannes Tesfaigzi, Oliver Lieleg, Janna C. Nawroth   +18 more
wiley   +1 more source

Sequence variation and molecular evolution of BMP4 genes

Genetics and Molecular Research, 2014
Bone morphogenetic protein 4 (BMP4) regulates skeletogenesis, osteoblastic differentiation, and the induction of hair follicles. Its protein-coding region contains a signal peptide, prodomain (which regulates post-translational synthesis), and a mature domain (which mediates gene function). Previous studies considered this gene to be conserved.
D J, Zhang, J H, Wu, G, Husile, H L, Sun, W G, Zhang   +4 more
openaire   +2 more sources

NOX4 knockdown inhibits proliferation of PASMCs under both control and BMP4 treatment circumstances A: control group was the control group absorbance at 490 nm, BMP4 group was absorbance of recombinant BMP4 protein intervention for 24 h group at 490 nm, #indicates P<0.01 vs. control group, the results are statistically significant.

, 2014
B: absorbance of rat distal PASMCS at 490 nm after transfection with NOX4 siRNA and knockout of NOX4, NC indicates negative control group; NOX4 siRNA indicates NOX4 gene silencing group; #indicates ...
Wenju Lu (430078), Kai Yang (73590), Lichun Tian (320047), Jie Zhang (64655), Yuqin Chen (627602), Xiuqing Chen (627603), Jian Wang (5901), Xin Fu (448766), Qian Jiang (216582)   +8 more
core   +1 more source

Immunohistochemically Localization of Bone Morphogenetic Proteins 4 in Bone Defect Healing Treated by Local Application of Hydroxyapatite/Beta-Tricalcium Phosphate and Hyaluronic Acid in Rats

Medical Journal of Babylon
Background: Bone naturally has the ability to regenerate as part of the healing process after injury. There are specific signaling molecules that can strictly control and organize these cellular events.
Ibtihal H. Radhi, Nada M. H. Al-Ghaban
doaj   +1 more source

BMP4 Gene Therapy in Mature Mice Reduces BAT Activation but Protects from Obesity by Browning Subcutaneous Adipose Tissue

Cell Reports, 2017
Summary: We examined the effect of Bone Morphogenetic Protein 4 (BMP4) on energy expenditure in adult mature mice by targeting the liver with adeno-associated viral (AAV) BMP4 vectors to increase circulating levels.
Jenny M. Hoffmann, John R. Grünberg, Christopher Church, Ivet Elias, Vilborg Palsdottir, John-Olov Jansson, Fatima Bosch, Ann Hammarstedt, Shahram Hedjazifar, Ulf Smith   +9 more
doaj   +1 more source