Results 81 to 90 of about 32,745 (240)

BMP4 upregulates glycogen synthesis through the SMAD/SLC2A1 (GLUT1) signaling axis in hepatocellular carcinoma (HCC) cells

Cancer & Metabolism, 2023
Background Excessive hepatic glycogen accumulation benefits tumorigenesis and cancer cell survival. We previously reported that BMP4 has the strongest ability to promote glycogenesis among the 14 BMPs in hepatocytes and augmented hepatocellular carcinoma
Jiamin Zhong, Luyao Tian, Yannian Gou, Piao Zhao, Xiangyu Dong, Meichun Guo, Guozhi Zhao, Aohua Li, Ailing Hao, Tong-Chuan He, Jiaming Fan   +10 more
doaj   +1 more source

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source

An adjustment in BMP4 function represents a treatment for diabetic nephropathy and podocyte injury [PDF]

, 2018
Podocyte injury has been proposed to play an important role in diabetic nephropathy; however, its pathological mechanism remains unclear. We have shown that bone morphogenetic protein 4 (BMP4) signaling leads to the glomerular changes characteristic of ...
ナガイ, コウジロウ, Saga, Yumiko, Abe, Hideharu, ウエダ, オトヤ, フジタ, ユイ, Jishage, Kou-ichi, 394, 495, 40542048, 1535, 398, 354, 333, サガ, ユミコ, 土井, 俊夫, 60183498, 80425446, 安部, 秀斉, 村上, 太一, Kanwar, Yashpal S., 60399342, カンガワ, ユミ, 10519507, ドイ, トシオ, Tominaga, Tatsuya, 30403736, Fujita, Yui, Kishi, Seiji, Ueda, Otoya, 長井, 幸二郎, 60048/profile-ja.html, Doi, Toshio, トミナガ, タツヤ, ジシャゲ, コウイチ, Fukushima, Naoshi, Murakami, Taichi, 冨永, 辰也, アベ, ヒデハル, フクシマ, ナオシ, 藤田, 結衣, Kangawa, Yumi, Nagai, Kojiro, ムラカミ, タイチ, 193358/profile-ja.html, 岸, 誠司, キシ, セイジ   +45 more
core  

Immunohistochemical mapping of BMP4 in developing chick heart.

, 2009
BMP4 plays an important role in cardiogenesis. BMP4 was immunohistochemically mapped in the myocardium of the outflow tract, the walls of the atria and the ventricular myocardium of 5-6 day old chick heart.
Asokan, Sureetha
core   +1 more source

Single-Molecule Imaging of Bmp4 Dimerization on Human Periodontal Ligament Cells

, 2012
We expressed bone morphogenetic protein 4 (BMP4) fused with enhanced green fluorescent protein (BMP4-EGFP) in the secretory pathways of producer cells. Fluorescent EGFP was acquired only after we interrupted the transport of BMP4- EGFP by culturing cells
秘心吾;姜昱至;周綠蘋;林俊彬, MI, HSIN-WU;CHIANG, YU-CHIH;CHOW, LU-PING;LIN, CHUN-PIN   +1 more
core   +2 more sources

Comprehensive analyses of single-cell and bulk RNA-seq reveal the biological and prognostic roles of BMP4 in pancreatic adenocarcinoma

Frontiers in Molecular Biosciences
Bone Morphogenetic Protein 4 (BMP4) plays a critical role in development, but its function in pancreatic adenocarcinoma (PAAD) is not well understood.
Ao Wang, Xinglong Shen, Shan Lu, Chao Bi, Yang Cao, Yunfeng Liu, Meng Li, Yun Zhao, Huaizhang Jin, Xiaopeng Shen, Wei Dai, Yang Lei   +11 more
doaj   +1 more source

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source

Hypoxia induces the transcription of BMP4.

, 2013
(A) RT-PCR analysis of BMP4, Hif1α, Hif1β, Hif2α or β-actin (control) expression in the MSS31 spleen stromal cell line (top); BMP4 and 28S rRNA (control) in the W2017 osteoblast cell line (middle) and BMP4 and 28S rRNA (control) in the AFT024 fetal liver
Dai-Chen Wu (363709), Robert F. Paulson (363711)   +1 more
core   +1 more source

Recurrent BMP4 variants in exon 4 cause non-HFE-associated hemochromatosis via the BMP/SMAD signaling pathway

Orphanet Journal of Rare Diseases
Background Hereditary hemochromatosis (HH) is an iron overload disorder and can be caused by variants in non-HFE genes in Chinese patients. However, there is still a considerable proportion of patients suffering from unexplained iron overload.
Qin Ouyang, Yanmeng Li, Anjian Xu, Ning Zhang, Sisi Chen, Donghu Zhou, Bei Zhang, Xiaojuan Ou, Jidong Jia, Jian Huang, Wei Zhang   +10 more
doaj   +1 more source

BMP4 Induces Cardiomyocyte Hypertrophy Through the Activation of ERK 1/2 Signaling Pathway in H9c2 Cells [PDF]

Brazilian Archives of Biology and Technology
Bone morphogenetic protein-4 (BMP4) is a member of the bone morphogenetic protein family which plays an important role in bone formation, inflammation and cardiac hypertrophy.
Yu Yuan, Yezheng Tao, Yongzhi Deng, Qunhui Ye, Bin Lin, Lin Wu   +5 more
doaj   +2 more sources