Results 91 to 100 of about 32,745 (240)

Thioredoxin‐2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation

Advanced Science, EarlyView.
Endothelial TRX2 preserves bone homeostasis by retaining FOXO3a at mitochondria and limiting TRAIL production. Loss of TRX2 or oxidative stress releases FOXO3a for nuclear translocation, increasing endothelial TRAIL secretion and driving osteoclast formation and bone loss.
Chi Zhan, Zhaocai Zhou, Yue Ding, Rong Lian, Xinyu Li, Xintong Zhang, Jie Cao, Zhonghui Tang, Zhengmei Lin, Zhi Song, Feng He   +10 more
wiley   +1 more source

BMP4 regulates the hematopoietic stem cell niche

Blood, 2009
Abstract Bone morphogenetic protein 4 (BMP4) is required for mesoderm commitment to the hematopoietic lineage during early embryogenesis. However, deletion of BMP4 is early embryonically lethal and its functional role in definitive hematopoiesis is unknown.
Devorah C, Goldman, Alexis S, Bailey, Dana L, Pfaffle, Azzah, Al Masri, Jan L, Christian, William H, Fleming   +5 more
openaire   +3 more sources

Bmp4 and luciferase proteins in pancreatic islets.

, 2013
Immunohistochemical analysis of pancreas (A–D) and liver (E–H) of wild-type (A, C, E, G) and transgenic mice (B, D, F, H) was performed using antibodies to Bmp4 (A, B, E, F) and luciferase (C, D, G, H).
Mitsuhiko Osaki (202660), Tomoko Nakanishi (344291), Nao Oumi (344289), Mayu Yasunaga (344288), Yasuhiro Kazuki (202667), Kenzo Sato (344293), Mitsuo Oshimura (8238)   +6 more
core   +1 more source

Sacral Neural Crest‐Derived Extracellular Vesicles Promote Pelvic Ganglion Repair Through Anti‐Pyroptotic Effects Involving ANXA1–FPR2 Signaling

Advanced Science, EarlyView.
Extracellular vesicles derived from human pluripotent stem cell‐derived sacral neural crest cells promote repair of injured major pelvic ganglia and improve colorectal function. These vesicles reduce oxidative stress and pyroptosis, with ANXA1–FPR2 signaling contributing to their protective effects, and show a favorable therapeutic profile compared ...
Ting Yang, Wenwei Liu, Hufei Wang, Yuxin Wu, Yuanchen Ma, Xiaofeng Wang, Tianxiang Lei, Qiao Tang, Yebohao Zhou, Weiqiang Li, Andy Peng Xiang, Wu Song   +11 more
wiley   +1 more source

Threshold-specific requirements for Bmp4 in mandibular development

Developmental Biology, 2005
Mandibular development is regulated by an interplay between a specified branchial arch ectoderm and a plastic mesenchyme. Moreover, signaling from the pharyngeal endoderm has been shown to be important for mandibular morphogenesis. To gain insight into the mechanisms regulating mandibular pattern, it is important to investigate the function of the ...
Liu, Wei, Selever, Jennifer, Murali, Deepa, Sun, Xiaoxia, Brugger, Sean M., Ma, Lijiang, Schwartz, Robert J., Maxson, Robert, Furuta, Yasuhide, Martin, James F.   +9 more
openaire   +2 more sources

BMP4 and BMP antagonists regulate human white and beige adipogenesis

, 2015
The limited expandability of subcutaneous adipose tissue, due to reduced ability to recruit and differentiate new adipocytes, prevents its buffering effect in obesity and is characterized by expanded adipocytes (hypertrophic obesity).
Svensson, Per-Arne,, Rondinone, Cristina, Hammarstedt, Ann,, Gustafson, Birgit,, Smith, Ulf,, Grimsby, Joseph, Hedjazifar, Shahram,, Hoffmann, Jenny M,   +7 more
core   +1 more source

ViTAMIn‐O: Democratizing Computer Vision‐Based Machine Learning for Stem Cell Research

Advanced Intelligent Systems, EarlyView.
This study introduces a fully open generalist computer vision model for predicting the differentiation outcomes of stem cell‐based model systems, together with its code‐free deployment platform, ColabViTAMIn‐O. It is benchmarked against various architectures, datasets, and training protocols.
Ferhat Hamurcu, Markus Breunig, Arpad Varga, Bianka Bosch, Jessica Lindenmayer, Anjan T. Kanakappady, Kevin Achberger, Natalia Pashkovskaia, Alexander Kleger, Stefan Liebau, Stefanie Klingenstein, Moritz Klingenstein   +11 more
wiley   +1 more source

Divergent and Compensatory Effects of BMP2 and BMP4 on the VSMC Phenotype and BMP4’s Role in Thoracic Aortic Aneurysm Development

Cells
Vascular smooth muscle cells (VSMCs) play a key role in aortic aneurysm formation. Bone morphogenetic proteins (BMPs) have been implicated as important regulators of VSMC phenotype, and dysregulation of the BMP pathway has been shown to be associated with vascular diseases.
Daniel Klessinger, Argen Mamazhakypov, Sophie Glaeser, Ramona Emig, Remi Peyronnet, Lena Meier, Kora Proelss, Katia Marenne, Christian Smolka, Sebastian Grundmann, Franziska Pankratz, Philipp R. Esser, Martin Moser, Qian Zhou, Jennifer S. Esser   +14 more
openaire   +4 more sources

Bone morphogenetic protein 4 meets artificial intelligence: a comprehensive review of AI-driven advances in drug discovery, structural modeling, and clinical translation

Frontiers in Molecular Biosciences
BackgroundBone Morphogenetic Protein 4 (BMP4), a member of the transforming growth factor-beta (TGF-β) superfamily, plays pivotal roles in embryonic development, tissue homeostasis, and disease pathogenesis—including cancer, fibrosis, and fibrodysplasia ...
Wanli Sun, Wanli Sun, Tongtong Huo, Tongtong Huo, Zhewei Ye, Wu Wei, Yanqing Sun, Yanqing Sun, Hui Cai, Hui Cai, Hui Cai, Hui Cai   +11 more
doaj   +1 more source

Early stages of tooth development in the harbor porpoise Phocoena phocoena

The Anatomical Record, EarlyView.
Abstract Here we describe the stages of tooth development in toothed whales on the basis of the harbor porpoise (Phocoena phocoena). The aim of the study was to find out whether these stages are identical to those of other mammals analyzed so far although toothed whales are homodont and monophyodont.
Lasse M. Mathes, Lennart Müller‐Thomsen, Stefan Huggenberger   +2 more
wiley   +1 more source