Results 111 to 120 of about 32,745 (240)

Mutations that prevent phosphorylation of the BMP4 prodomain impair proteolytic maturation of homodimers leading to lethality in mice

eLife
Bone morphogenetic protein4 (BMP4) plays numerous roles during embryogenesis and can signal either alone as a homodimer, or together with BMP7 as a more active heterodimer.
Hyung-Seok Kim, Mary L Sanchez, Joshua Silva, Heidi L Schubert, Rebecca Dennis, Christopher P Hill, Jan L Christian   +6 more
doaj   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source

Bone morphogenetic protein 4 (BMP4) expression.

, 2013
Representative images for BMP4 expression in the thymus are shown for controls (A), 7 d LPS (B), 14 d LPS (C) and 14 d LPS+7 d Beta group (D). E: BMP4 protein expression decreased in the 7 d and 14 d LPS and the 14 d LPS+7 d Beta groups.
Jennifer J. P. Collins (127090), Reint K. Jellema (127097), Wilfred T. V. Germeraad (320775), Tim G. A. M. Wolfs (320769), Graeme R. Polglase (318443), John P. Newnham (140913), Elke Kuypers (127094), Ilias Nitsos (320773), Boris W. Kramer (110855), Matthew W. Kemp (320771), Alan H. Jobe (320777), J. Jane Pillow (320774), Suhas G. Kallapur (320776)   +12 more
core   +1 more source

Multi‐Target Pharmacological Mechanisms of Salvia miltiorrhiza Bunge in Metabolic Syndrome and Cardiovascular Diseases: A Comprehensive Review Based on the Theory of “Same Treatment for Different Diseases”

Phytotherapy Research, EarlyView.
Salvia miltiorrhiza Bunge in metabolic syndrome and cardiovascular diseases: multi‐target actions on shared signaling pathways. ABSTRACT Metabolic syndrome (MetS) represents a clinical disorder characterized by the clustering of conditions including obesity, elevated blood sugar levels, and high lipid levels, which are intricately linked to the onset ...
Zhiyi Jia, Kaiyi Wu, Jiaying Qi, Nana Huang, Yusheng Liu, Xiumei Gao, Rong Sun   +6 more
wiley   +1 more source

Mogroside V Promotes Brown Adipose Thermogenesis via FTO‐m6A‐LETMD1‐UCP1 Pathway to Combat Obesity

Phytotherapy Research, EarlyView.
Mogroside V (MV) alleviates high‐fat diet‐induced obesity and metabolic dysfunction. Mechanistically, MV suppresses FTO expression, thereby increasing m6A modification of Letmd1 mRNA and enhancing its YTHDC2‐dependent stabilization. Theincreased LETMD1 expression is associated with elevated PGC1α and UCP1 levels, contributing to brown adipocyte ...
Yuan‐hai Sun, Ling‐huan Li, Ya‐qian Feng, Teng‐jiao Zhao, Min‐you Qi, Han‐bing Li   +5 more
wiley   +1 more source

Biomaterial Platforms for Spatiotemporal Control of mRNA Delivery in Tissue Engineering and Regenerative Medicine: Design Rules, Therapeutic Applications, and Translational Roadmap

Small, EarlyView.
Biomaterial platforms can control where and when mRNA‐encoded proteins are expressed to support tissue repair. This Review proposes a cargo–target–timing framework linking therapeutic function, target tissues and cells, and expression profiles with carrier and scaffold design.
Huachun Pan, Shumin Yang, Katarina Holubova, Huifang Yin, Hongbo Chen, Xintian Zheng, Xiangan Han, Jinqiu Zhang, Xueping Li, Hui Zhang, Xiaojun Cai, Václav Slovák, Lihong Zhang, Quan Mo, Quazi T. H. Shubhra   +14 more
wiley   +1 more source

Evaluating Thiram‐Induced Embryotoxicity Using Integrated In Silico, In Vitro, and Transcriptomic Approaches

Environmental Toxicology, EarlyView.
ABSTRACT Long‐term exposure to low‐dose food contact materials (FCMs) has raised concerns regarding developmental toxicity. In the present study, we prioritized FCMs with potential developmental toxicity using a weight‐of‐evidence computational model, which predicted 127 chemicals to be of high concern.
Chia‐Chi Ho, Chun‐Wei Tung, B. Linju Yen, Chen‐Yi Weng, Ju‐Hsin Hsu, Ming‐Hsien Tsai, Salim Arrokhman, Pinpin Lin   +7 more
wiley   +1 more source

Human iPSC‐Derived Vascularised Lung Organoids for Modelling COPD and Pulmonary Hypertension

Cell Proliferation, EarlyView.
Vascularised lung organoids (vLOs) that faithfully mimic human lung tissue architecture and disease pathology are critical for advancing pulmonary research but remain challenging to generate. Here, we developed a robust self‐organisation protocol to produce vLOs with cellular heterogeneity and functional vasculature. The engineered blood vessels within
Simin Jiang, Liangliang Tian, Jingge Qu, Yi Hong, Dian Chen, Zihang Pan, Huanyu Long, Lanhe Chu, Weijing Kong, Qiyang Yao, Xiaojing Ma, Yun Zhao, Baihui Ma, Kai Wang, Yahong Chen   +14 more
wiley   +1 more source

Bone morphogenetic protein 4 promotes the survival and preserves the structure of flow-sorted Bhlhb5+ cochlear spiral ganglion neurons in vitro

Scientific Reports, 2017
SGNs are the primary auditory neurons, and damage or loss of SGNs leads to sensorineural hearing loss. BMP4 is a growth factor that belongs to the TGF-β superfamily and has been shown to play a key role during development, but little is known about its ...
Muhammad Waqas, Shan Sun, Chuanyin Xuan, Qiaojun Fang, Xiaoli Zhang, Irum-us Islam, Jieyu Qi, Shasha Zhang, Xia Gao, Mingliang Tang, Haibo Shi, Huawei Li, Renjie Chai   +12 more
doaj   +1 more source

An evolutionarily conserved enhancer regulates Bmp4 expression in developing incisor and limb bud.

PLoS ONE, 2012
To elucidate the transcriptional regulation of Bmp4 expression during organogenesis, we used phylogenetic footprinting and transgenic reporter analyses to identify Bmp4 cis-regulatory modules (CRMs). These analyses identified a regulatory region located ∼
Dolrudee Jumlongras, Salil A Lachke, Daniel J O'Connell, Anton Aboukhalil, Xiao Li, Sung E Choe, Joshua W K Ho, Annick Turbe-Doan, Erin A Robertson, Bjorn R Olsen, Martha L Bulyk, Brad A Amendt, Richard L Maas   +12 more
doaj   +1 more source