Results 111 to 120 of about 26,444 (201)

Pathophysiological and Molecular Features of DXd ADC‐Related Interstitial Pneumonitis in Cynomolgus Monkeys

Cancer Science, Volume 117, Issue 8, Page 2305-2316, August 2026.
An interstitial lung disease model for DXd antibody‐drug conjugates was established in cynomolgus monkeys by weekly dosing of a non‐targeting DXd ADC. Integrated analysis of bronchoalveolar lavage fluid–derived extracellular vesicle proteomics and lung single‐cell RNA sequencing reveals cell‐type‐resolved molecular features of DXd ADC‐related lung ...
Kazuyoshi Kumagai, Takuma Iguchi, Kentaro Kubota, Ken Sakurai, Yoshimi Tsuchiya, Katsuyoshi Chiba   +5 more
wiley   +1 more source

Establishment of Human Formative Pluripotent Stem Cell‐Like Cells Exhibiting Amniotic Differentiation Potentials

Cell Proliferation, Volume 59, Issue 8, August 2026.
The hfPSC‐LCs could be established from naïve hESCs, conventional hESCs, hiPSCs, and human blastocysts. The hfPSC‐LCs hold robust capacity for three germ layers, hPGCLCs, and hALPCs. ABSTRACT Human embryos undergo pivotal morphogenetic remodelling shortly after implantation. The understanding of this crucial stage is severely impeded by the scarcity of
Xiaoxiao Wang, Qizhi Wang, Yu Wu, Chen Gu, Mingfei Li, Yong Fan, Xiangjin Kang, Lei Li, Zheng Gao, Mingyan Hei, Jianqiao Liu, Lei Li   +11 more
wiley   +1 more source

Overexpression of Bmp4 induces microphthalmia by disrupting embryonic neural retina

Neurobiology of Disease
Microphthalmia, mostly an autosomal dominant disorder, is a worldwide severe congenital ocular malformation that causes visual impairment. Our investigation unveiled a total of 30 genes associated with microphthalmia.
Baige Li, Zeyuan Pu, Keren Liao, Yuxin Du, Gao Tan, Scott Nawy, Shiqiang Gao, Yin Shen   +7 more
doaj   +1 more source

Unexpected Promotion of Bone Regeneration by Inhibition of BMPR1A‐Mediated BMP Signalling

Cell Proliferation, Volume 59, Issue 8, August 2026.
BMPR1A downregulation reduces ID1, releases TCF3 to activate GNG4‐PI3K‐AKT signalling, thereby promoting OPC proliferation and bone regeneration. ABSTRACT Bone morphogenetic protein (BMP) signalling plays a pivotal role in bone regeneration by regulating osteoprogenitor cell (OPC) function, and BMPs have been widely used in clinical treatment. However,
Zihao Zhou, Yun Zhai, Xiaochen Liu, Jiaojiao Shao, Jiani Zhou, Zhaoyang Li, Jiale He, Shuxian Lin, Qi Zhang   +8 more
wiley   +1 more source

BMP4 Gene [PDF]

, 2020
openaire   +1 more source

Bone morphogenetic protein 4-associated mitochondrial dysfunction in diabetic nephropathy involves Parkin downregulation

Frontiers in Clinical Diabetes and Healthcare
BackgroundDiabetic nephropathy (DN) is characterized by mesangial expansion and mitochondrial dysfunction. Although bone morphogenetic protein 4 (BMP4) is a pro-fibrotic factor in DN, its role in mesangial mitochondrial homeostasis remains unclear.
Masanori Tamaki, Tatsuya Tominaga, Kazuhiro Hasegawa, Takahiro Kida, Shinji Miyakami, Ikuko Shimizu, Sumiyo Yamaguchi, Masanori Minato, Kojiro Nagai, Kojiro Nagai, Shu Wakino   +10 more
doaj   +1 more source

BMP4 wt Allele [PDF]

, 2020
openaire   +1 more source

Human BMP4 mRNA Encapsulated in Lipid Nanoparticle for Bone and Articular Cartilage Repair in Aged Mice. [PDF]

J Funct Biomater
Gao X, Xiao Z, Huard M, Nakayama K, Cummings A, Force BS, Li H, Mancino C, Cooke JP, Taraballi F, Philippon MJ, Huard J.   +11 more
europepmc   +1 more source

Hyperoxia promotes bronchopulmonary dysplasia via Noggin-mediated BMP4 antagonism and cellular senescence. [PDF]

Front Physiol
Zhang J, Quan J, Luo Y, Zhang Z, Li T, Xi S.   +5 more
europepmc   +1 more source

Telomerase reverse transcriptase mediates bone formation for osteoporosis via activating BMP4/Smad1 pathway. [PDF]

J Orthop Translat
Ma J, Yuan X, Xiao Y, Wang H, Hong Y, Zhang Y, Chen Y, Zheng H, Li J, Li B.   +9 more
europepmc   +1 more source