Results 61 to 70 of about 26,444 (201)

BMP4 Was Associated with NSCL/P in an Asian Population

PLoS ONE, 2012
The Bone Morphogenetic Protein 4 gene (BMP4) is located in chromosome 14q22-q23 which has shown evidence of linkage for isolated nonsyndromic cleft lip with or without cleft palate (NSCL/P) in a genome wide linkage analysis of human multiplex families. BMP4 has been shown to play crucial roles in lip and palatal development in animal models.
Chen Q., Wang H., Hetmanski J.B., Zhang T., Ruczinski I., Schwender H., Liang K.Y., Fallin M.D., Redett R.J., Raymond G.V., Chou Y.-H., ChenPhilip K.-T., Yeow V., Chong S.S., Cheah F.S.H., Jabs E.W., Scott A.F., Beaty T.H.   +17 more
openaire   +4 more sources

SIX2 and BMP4 Mutations Associate With Anomalous Kidney Development [PDF]

Journal of the American Society of Nephrology, 2008
Renal hypodysplasia (RHD) is characterized by reduced kidney size and/or maldevelopment of the renal tissue following abnormal organogenesis. Mutations in renal developmental genes have been identified in a subset of affected individuals. Here, we report the first mutations in BMP4 and SIX2 identified in patients with RHD.
Weber, Stefanie, Taylor, Jaclyn C., Winyard, Paul, Baker, Kari F., Sullivan-Brown, Jessica, Schild, Raphael, Knueppel, Tanja, Zurowska, Aleksandra M., Caldas-Alfonso, Alberto, Litwin, Mieczyslaw, Emre, Sevinc, Ghiggeri, Gian Marco, Bakkaloglu, Aysin, Mehls, Otto, Antignac, Corinne, Network, Escape, Schaefer, Franz, Burdine, Rebecca D.   +17 more
openaire   +3 more sources

Immunohistochemically Localization of Bone Morphogenetic Proteins 4 in Bone Defect Healing Treated by Local Application of Hydroxyapatite/Beta-Tricalcium Phosphate and Hyaluronic Acid in Rats

Medical Journal of Babylon
Background: Bone naturally has the ability to regenerate as part of the healing process after injury. There are specific signaling molecules that can strictly control and organize these cellular events.
Ibtihal H. Radhi, Nada M. H. Al-Ghaban
doaj   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Early stages of tooth development in the harbor porpoise Phocoena phocoena

The Anatomical Record, EarlyView.
Abstract Here we describe the stages of tooth development in toothed whales on the basis of the harbor porpoise (Phocoena phocoena). The aim of the study was to find out whether these stages are identical to those of other mammals analyzed so far although toothed whales are homodont and monophyodont.
Lasse M. Mathes, Lennart Müller‐Thomsen, Stefan Huggenberger   +2 more
wiley   +1 more source

Sequence variation and molecular evolution of BMP4 genes

Genetics and Molecular Research, 2014
Bone morphogenetic protein 4 (BMP4) regulates skeletogenesis, osteoblastic differentiation, and the induction of hair follicles. Its protein-coding region contains a signal peptide, prodomain (which regulates post-translational synthesis), and a mature domain (which mediates gene function). Previous studies considered this gene to be conserved.
D J, Zhang, J H, Wu, G, Husile, H L, Sun, W G, Zhang   +4 more
openaire   +2 more sources

BMP4 Induces Cardiomyocyte Hypertrophy Through the Activation of ERK 1/2 Signaling Pathway in H9c2 Cells [PDF]

Brazilian Archives of Biology and Technology
Bone morphogenetic protein-4 (BMP4) is a member of the bone morphogenetic protein family which plays an important role in bone formation, inflammation and cardiac hypertrophy.
Yu Yuan, Yezheng Tao, Yongzhi Deng, Qunhui Ye, Bin Lin, Lin Wu   +5 more
doaj   +2 more sources

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Threshold-specific requirements for Bmp4 in mandibular development

Developmental Biology, 2005
Mandibular development is regulated by an interplay between a specified branchial arch ectoderm and a plastic mesenchyme. Moreover, signaling from the pharyngeal endoderm has been shown to be important for mandibular morphogenesis. To gain insight into the mechanisms regulating mandibular pattern, it is important to investigate the function of the ...
Liu, Wei, Selever, Jennifer, Murali, Deepa, Sun, Xiaoxia, Brugger, Sean M., Ma, Lijiang, Schwartz, Robert J., Maxson, Robert, Furuta, Yasuhide, Martin, James F.   +9 more
openaire   +2 more sources

Recurrent BMP4 variants in exon 4 cause non-HFE-associated hemochromatosis via the BMP/SMAD signaling pathway

Orphanet Journal of Rare Diseases
Background Hereditary hemochromatosis (HH) is an iron overload disorder and can be caused by variants in non-HFE genes in Chinese patients. However, there is still a considerable proportion of patients suffering from unexplained iron overload.
Qin Ouyang, Yanmeng Li, Anjian Xu, Ning Zhang, Sisi Chen, Donghu Zhou, Bei Zhang, Xiaojuan Ou, Jidong Jia, Jian Huang, Wei Zhang   +10 more
doaj   +1 more source