Results 61 to 70 of about 32,745 (240)

Bmp4 Promotes a Brown to White-like Adipocyte Shift [PDF]

Cell Reports, 2016
ISSN:2211 ...
Modica, Salvatore, Straub, Leon G., Balaz, Miroslav, Sun, Wenfei, Varga, Lukas, Stefanicka, Patrik, Profant, Milan, Simon, Eric, Neubauer, Heike, Ukropcova, Barbara, Ukropec, Jozef, Wolfrum, Christian   +11 more
openaire   +5 more sources

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Bone morphogenetic protein 4 rescues the bone regenerative potential of old muscle-derived stem cells via regulation of cell cycle inhibitors

Stem Cell Research & Therapy, 2022
Background Bone morphogenetic protein 4 (BMP4) promotes the osteogenic differentiation and the bone regenerative potential of muscle-derived stem cells (MDSCs).
Haizi Cheng, Xueqin Gao, Matthieu Huard, Aiping Lu, Joseph J. Ruzbarsky, Sara Amra, Bing Wang, Johnny Huard   +7 more
doaj   +1 more source

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

BMP4 Was Associated with NSCL/P in an Asian Population

PLoS ONE, 2012
The Bone Morphogenetic Protein 4 gene (BMP4) is located in chromosome 14q22-q23 which has shown evidence of linkage for isolated nonsyndromic cleft lip with or without cleft palate (NSCL/P) in a genome wide linkage analysis of human multiplex families. BMP4 has been shown to play crucial roles in lip and palatal development in animal models.
Chen Q., Wang H., Hetmanski J.B., Zhang T., Ruczinski I., Schwender H., Liang K.Y., Fallin M.D., Redett R.J., Raymond G.V., Chou Y.-H., ChenPhilip K.-T., Yeow V., Chong S.S., Cheah F.S.H., Jabs E.W., Scott A.F., Beaty T.H.   +17 more
openaire   +4 more sources

Evaluation of germline BMP4 mutation as a cause of colorectal cancer [PDF]

Human Mutation, 2010
Transforming growth factor-β (TGF-β) signalling plays a key role in colorectal cancer (CRC). Bone morphogenetic protein-4 (BMP4) is a member of the TGF-β family of signal transduction molecules. To examine if germline mutation in BMP4 causes CRC we analysed 504 genetically enriched CRC cases (by virtue of early-onset disease, family history of CRC) for
Lubbe, Steven, Matijssen, Cornelis, Pittman, Alan M, Twiss, Philip, Olver, Bianca, Llyod, Amy, Qureshi, Mobshra, Brown, Nathan, Nye, Emma, Stamp, Gordon, Blagg, Julian, Houlston, Richard S.   +11 more
openaire   +3 more sources

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source

Differential expression of a BMP4 reporter allele in anterior fungiform versus posterior circumvallate taste buds of mice

BMC Neuroscience, 2010
Background Bone Morphogenetic Protein 4 (BMP4) is a diffusible factor which regulates embryonic taste organ development. However, the role of BMP4 in taste buds of adult mice is unknown. We utilized transgenic mice with LacZ under the control of the BMP4
Barlow Linda A, Nguyen Ha M
doaj   +1 more source

CD34/c-Kit aorta-gonad-mesonephros (AGM) cells cultured with bone morphogenetic protein 4 (BMP4) generate adherent colonies resembling CD34/c-Kit colonies

, 2011
(A) CD34/c-Kit cells isolated by FACS from AGM tissue (10·5 dpc) and cultured for 10 d in serum-free medium alone (−BMP4) generate haematopoietic colonies composed of granulocytic/myeloid cells (CFU-GM).
Joanna C Sinclair (91388), Christine Kinnon (91390), Caroline J Marshall (91387), Adrian J Thrasher (91389)   +3 more
core   +1 more source

BMP4 depletion by miR-200 inhibits tumorigenesis and metastasis of lung adenocarcinoma cells

, 2021
Background: MicroRNA-200 (miR-200) suppresses the epithelial-mesenchymal transition of various cancer cells, including lung adenocarcinoma cells.
안영호
core   +1 more source