Results 41 to 50 of about 26,444 (201)

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

Mutations in BMP4 Cause Eye, Brain, and Digit Developmental Anomalies: Overlap between the BMP4 and Hedgehog Signaling Pathways [PDF]

The American Journal of Human Genetics, 2008
Developmental ocular malformations, including anophthalmia-microphthalmia (AM), are heterogeneous disorders with frequent sporadic or non-Mendelian inheritance. Recurrent interstitial deletions of 14q22-q23 have been associated with AM, sometimes with poly/syndactyly and hypopituitarism.
Bakrania, P., Efthymiou, M., Klein, J.C., Salt, A., Bunyan, D.J., Wyatt, A., Ponting, C.P., Martin, A., Williams, S., Lindley, V., Gilmore, J., Restori, M., Robson, A.G., Neveu, M.M., Holder, G.E., Collin, J.R., Robinson, D.O., Farndon, P., Johansen-Berg, H., Gerrelli, D., Ragge, N.K.   +20 more
openaire   +3 more sources

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

Developmental expression of BMP4/ALK3/SMAD5 signaling pathway in the mouse testis: a potential role of BMP4 in spermatogonia differentiation [PDF]

Journal of Cell Science, 2003
It is well established that the c-kit gene plays an essential role in the proliferation of differentiating spermatogonia in prepuberal mice. However, the mechanisms that regulate the onset of spermatogenesis, i.e. differentiation of spermatogonial stem cells and c-kit expression,are poorly understood. Here we identify a novel signal transduction system
Pellegrini, M, GRIMALDI, PAOLA, ROSSI, PELLEGRINO, GEREMIA, RAFFAELE, DOLCI IANNINI, SUSANNA   +4 more
openaire   +5 more sources

Bone morphogenetic protein 4 rescues the bone regenerative potential of old muscle-derived stem cells via regulation of cell cycle inhibitors

Stem Cell Research & Therapy, 2022
Background Bone morphogenetic protein 4 (BMP4) promotes the osteogenic differentiation and the bone regenerative potential of muscle-derived stem cells (MDSCs).
Haizi Cheng, Xueqin Gao, Matthieu Huard, Aiping Lu, Joseph J. Ruzbarsky, Sara Amra, Bing Wang, Johnny Huard   +7 more
doaj   +1 more source

Notch signaling-mediated osteocytic overexpression of BMP4 promotes osteogenic differentiation of bone marrow stromal cells

Di-san junyi daxue xuebao, 2021
Objective To investigate the effect of bone morphogenetic protein 4 (BMP4) overexpression in MLO-Y4 osteocytes on osteogenic differentiation of bone marrow stromal ST2 cells through Notch signaling. Methods Ad-GFP or Ad-BMP4 infected MLO-Y4 cells were co-
XIE Zhengsong, ZHAO Yixin, LYU Ziling, LIU Hong, TU Xiaolin   +4 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

BMP4 (bone morphogenetic protein 4) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013
Review on BMP4 (bone morphogenetic protein 4), with data on DNA, on the protein encoded, and where the gene is implicated.
Thériault, BL, Nachtigal, MW
openaire   +2 more sources

Differential expression of a BMP4 reporter allele in anterior fungiform versus posterior circumvallate taste buds of mice

BMC Neuroscience, 2010
Background Bone Morphogenetic Protein 4 (BMP4) is a diffusible factor which regulates embryonic taste organ development. However, the role of BMP4 in taste buds of adult mice is unknown. We utilized transgenic mice with LacZ under the control of the BMP4
Barlow Linda A, Nguyen Ha M
doaj   +1 more source

Cyclic Mechanical Loading of Cardiomyocytes via Pressure‐Driven Non‐Planar Membrane Deformation in a Bioreactor System

Advanced Science, EarlyView.
In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor, Gabrielle Juul, Jil Patel, Heran Pradhan, Gram Hepner, Jackson Jewell, Mark Bardin, Ryan Slusser, Abigail Glezer, Leda Klouda, Melikhan Tanyeri, Anita Saraf   +11 more
wiley   +1 more source