Results 21 to 30 of about 32,745 (240)
BMP4, a new prognostic factor for glioma [PDF]
World Journal of Surgical Oncology, 2013 The expression status of bone morphogenetic protein 4 (BMP4) in gliomas is still unclear by now. We try to investigate the relationship between BMP4 expression and the biological behavior of gliomas in order to lay a foundation for the management of these tumors.A total of 630 patients with glioma were enrolled in the study from January 2002 to January
Wu, Qiang, Yao, Jiarui
openaire +2 more sources
Verification of bmp4;wnt5 knockdown.
, 2023 Left: qPCR to detect expression of bmp4 transcript (normalized to ubiquilin control) to detect knockdown of bmp4 in bmp4 RNAi and bmp4;wnt5 RNAi. Animals were treated with dsRNA for 20 days (9 dsRNA feedings), followed by isolation of RNA, followed by RT-
Eleanor G. Clark (17015069) +1 more
core +1 more source
The prodomain of BMP4 is necessary and sufficient to generate stable BMP4/7 heterodimers with enhanced bioactivity in vivo [PDF]
Proceedings of the National Academy of Sciences, 2015 Significance Bone morphogenetic proteins (BMPs) are made as inactive precursor proteins that dimerize and are cleaved to generate a bioactive ligand along with prodomain fragments that lack signaling activity. BMP ligands signal as either homodimers, or as heterodimers that display significantly higher activity in vivo.
Judith M, Neugebauer +6 more
openaire +2 more sources
BMC Cancer, 2023 Background The detailed molecular mechanism between type 2 diabetes mellitus (T2DM) and colorectal cancer (CRC) is still uncertain. Bone morphogenetic protein 4 (BMP4) dysregulation is implicated in T2DM and CRC, respectively.
Bingwei Ma +6 more
doaj +1 more source
Ciliary margin-derived BMP4 does not have a major role in ocular development. [PDF]
PLoS ONE, 2018 Heterozygous Bmp4 mutations in humans and mice cause severe ocular anterior segment dysgenesis (ASD). Abnormalities include pupil displacement, corneal opacity, iridocorneal adhesions, and variable intraocular pressure, as well as some retinal and ...
Rebecca L Rausch +2 more
doaj +1 more source
Agrin Binds BMP2, BMP4 and TGFβ1
PLoS ONE, 2010 The C-terminal 95 kDa fragment of some isoforms of vertebrate agrins is sufficient to induce clustering of acetylcholine receptors but despite two decades of intense agrin research very little is known about the function of the other isoforms and the function of the larger, N-terminal part of agrins that is common to all isoforms.
Bányai László +2 more
openaire +6 more sources
BMP4 is essential for lens induction in the mouse embryo [PDF]
Genes & Development, 1998 Vertebrate lens development is a classical model system for studying embryonic tissue interactions. Little is known, however, about the molecules mediating such inductive events. Here, we show thatBmp4, which is expressed strongly in the optic vesicle and weakly in the surrounding mesenchyme and surface ectoderm, has crucial roles during lens induction.
Y, Furuta, B L, Hogan
openaire +2 more sources
Nephronectin regulates atrioventricular canal differentiation via Bmp4-Has2 signaling in zebrafish [PDF]
, 2011 The extracellular matrix is crucial for organogenesis. It is a complex and dynamic component that regulates cell behavior by modulating the activity, bioavailability and presentation of growth factors to cell surface receptors.
Novoyatleva, Tatyana +17 more
core +1 more source
BMP4 increases the expression of TRPC and basal [Ca2+]i via the p38MAPK and ERK1/2 pathways independent of BMPRII in PASMCs. [PDF]
PLoS ONE, 2014 Multiple abnormalities of bone morphogenetic protein (BMPs) signaling are implicated in the process of pulmonary arterial hypertension (PAH). BMP4 plays an important role during the process of pulmonary arterial remodeling and mutant of the principle ...
Yi Zhang +9 more
doaj +1 more source
Transcriptional regulation of BMP4 synexpression in transgenic Xenopus [PDF]
The EMBO Journal, 2004 Synexpression groups are genetic modules composed of genes that share both a complex expression pattern and the biological process in which they function. Here we investigate the regulation of BMP4 synexpression by studying the enhancers of bambi, smad7 and vent2 in Xenopus.
Emil, Karaulanov +2 more
openaire +2 more sources