Results 21 to 30 of about 26,444 (201)
Ciliary margin-derived BMP4 does not have a major role in ocular development. [PDF]
PLoS ONE, 2018 Heterozygous Bmp4 mutations in humans and mice cause severe ocular anterior segment dysgenesis (ASD). Abnormalities include pupil displacement, corneal opacity, iridocorneal adhesions, and variable intraocular pressure, as well as some retinal and ...
Rebecca L Rausch +2 more
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BMP4 increases the expression of TRPC and basal [Ca2+]i via the p38MAPK and ERK1/2 pathways independent of BMPRII in PASMCs. [PDF]
PLoS ONE, 2014 Multiple abnormalities of bone morphogenetic protein (BMPs) signaling are implicated in the process of pulmonary arterial hypertension (PAH). BMP4 plays an important role during the process of pulmonary arterial remodeling and mutant of the principle ...
Yi Zhang +9 more
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Agrin Binds BMP2, BMP4 and TGFβ1
PLoS ONE, 2010 The C-terminal 95 kDa fragment of some isoforms of vertebrate agrins is sufficient to induce clustering of acetylcholine receptors but despite two decades of intense agrin research very little is known about the function of the other isoforms and the function of the larger, N-terminal part of agrins that is common to all isoforms.
Bányai László +2 more
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BMP4 is essential for lens induction in the mouse embryo [PDF]
Genes & Development, 1998 Vertebrate lens development is a classical model system for studying embryonic tissue interactions. Little is known, however, about the molecules mediating such inductive events. Here, we show thatBmp4, which is expressed strongly in the optic vesicle and weakly in the surrounding mesenchyme and surface ectoderm, has crucial roles during lens induction.
Y, Furuta, B L, Hogan
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Cells, 2023 Bone Morphogenetic Protein 4 (BMP4) is a secreted growth factor of the Transforming Growth Factor beta (TGFβ) superfamily. The goal of this study was to test whether BMP4 contributes to the pathogenesis of diabetic retinopathy (DR). Immunofluorescence of
Noureldien H. E. Darwish +7 more
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Transcriptional regulation of BMP4 synexpression in transgenic Xenopus [PDF]
The EMBO Journal, 2004 Synexpression groups are genetic modules composed of genes that share both a complex expression pattern and the biological process in which they function. Here we investigate the regulation of BMP4 synexpression by studying the enhancers of bambi, smad7 and vent2 in Xenopus.
Emil, Karaulanov +2 more
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BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer’s disease
Cell Death Discovery, 2021 Alzheimer’s disease (AD) is a chronic progressive degenerative disease of the nervous system. Its pathogenesis is complex and is related to the abnormal expression of the amyloid β (Aβ), APP, and Tau proteins.
Xiaoqing Zhang +8 more
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Functional Concentrations of BMP4 on Differentiation of Mouse Embryonic Stem Cells to Primordial Germ Cells [PDF]
International Journal of Fertility and Sterility, 2011 Background Bone morphogenetic protein 4 (BMP4) has a significant role in primordial germ cells (PGCs) differentiation from mouse embryonic stem cell (mESC).
Hatef Ghasemi Hamidabadi +5 more
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Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia. [PDF]
PLoS ONE, 2010 Bone marrow erythropoiesis is primarily homeostatic, producing new erythrocytes at a constant rate. However at times of acute anemia, new erythrocytes must be rapidly produced much faster than bone marrow steady state erythropoiesis.
Dai-Chen Wu, Robert F Paulson
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BMP4 expression in the developing rat retina
Brain Research, 2006 We investigated the expression of bone morphogenetic protein-4 (BMP4) in the developing retina. At E19, we found very intense BMP4 immunoreactivity (IR) in the nerve fiber layer. At P1, the inner plexiform layer exhibited very strong BMP4-IR. Thereafter, abundant BMP4 expression was kept to the adult period.
Yuka, Maruyama +3 more
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