Results 11 to 20 of about 26,444 (201)

BMP-treated human embryonic stem cells transcriptionally resemble amnion cells in the monkey embryo

Biology Open, 2021
Human embryonic stem cells (hESCs) possess an immense potential to generate clinically relevant cell types and unveil mechanisms underlying early human development.
Sapna Chhabra, Aryeh Warmflash
doaj   +1 more source

BMP4 Activation and Secretion Are Negatively Regulated by an Intracellular Gremlin-BMP4 Interaction [PDF]

Journal of Biological Chemistry, 2006
Bone morphogenetic protein 4 (BMP4) is a potent growth factor that is involved in many important biological processes. Regulation of the level of secreted mature BMP4 determines the biological effects of BMP4 on cells in the local microenvironment. Previous studies suggested that Gremlin, a member of DAN family proteins, antagonizes BMP4 activity by ...
Sun, Jianping, Zhuang, Feng Feng, Mullersman, Jerald E., Chen, Hui, Robertson, Elizabeth J., Warburton, David, Liu, Yi Hsin, Shi, Wei   +7 more
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BMP4 aggravates mitochondrial dysfunction of HRMECs

Heliyon, 2023
Mitochondria are important places for the oxidative phosphorylation of glucose and the maintenance of cell oxidation and antioxidant stability. However, mitochondrial dysfunction causes cell dysfunction. Meanwhile, retinal vascular endothelial cell dysfunction may cause vascular inflammation, hemorrhage, angiogenesis, and other manifestations.
Yong Wang, Hui Li, Jingjing Cao, Aihua Liu, Zhenyu Kou, Weiting An, Jingli Liang, Xiaomin Zhang, Xiaorong Li, Lijie Dong   +9 more
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Cardiac Differentiation of Adipose Tissue-Derived Stem Cells Is Driven by BMP4 and bFGF but Counteracted by 5-Azacytidine and Valproic Acid

Cell Journal, 2020
Objective: Bone morphogenetic protein 4 (BMP4) and basic fibroblast growth factor (bFGF) play important roles in embryonic heart development.
Sanaz Hasani, Arash Javeri, Asadollah Asadi, Masoumeh Fakhr Taha   +3 more
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Bone morphogenetic protein 4 alleviates nonalcoholic steatohepatitis by inhibiting hepatic ferroptosis

Cell Death Discovery, 2022
Nonalcoholic steatohepatitis (NASH) is a state of simple steatosis that progresses to inflammation and liver injury accompanied by ferroptosis. Bone morphogenetic protein 4 (BMP4) plays an important role in adipogenesis and differentiation, as well as in
Xingchun Wang, Bingwei Ma, Xin Wen, Hui You, Chunjun Sheng, Le Bu, Shen Qu   +6 more
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A Wnt-BMP4 Signaling Axis Induces MSX and NOTCH Proteins and Promotes Growth Suppression and Differentiation in Neuroblastoma

Cells, 2020
The Wnt and bone morphogenetic protein (BMP) signaling pathways are known to be crucial in the development of neural crest lineages, including the sympathetic nervous system.
Marianna Szemes, Zsombor Melegh, Jacob Bellamy, Alexander Greenhough, Madhu Kollareddy, Daniel Catchpoole, Karim Malik   +6 more
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The role of BMP4 in adipose-derived stem cell differentiation: A minireview

Frontiers in Cell and Developmental Biology, 2022
Bone morphogenetic protein 4 (BMP4) is a member of the transforming growth factor beta (TGF-β) superfamily of cytokines responsible for stem cells’ commitment to differentiation, proliferation, and maturation.
Abdul Malik Setiawan, Abdul Malik Setiawan, Taty Anna Kamarudin, Norzana Abd Ghafar   +3 more
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The dual role of BMP4 in adipogenesis and metabolism [PDF]

Adipocyte, 2017
BMP4 has a well-established role in triggering commitment of mesenchymal stem cells into the osteogenic and adipogenic linage. We recently described an additional dual function in adipogenesis: after promoting the formation of both white and brown pre-adipocytes, Bmp4 drives terminal differentiation into mature white rather than brown fat cells ...
Salvatore, Modica, Christian, Wolfrum
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BMP4, a new prognostic factor for glioma [PDF]

World Journal of Surgical Oncology, 2013
The expression status of bone morphogenetic protein 4 (BMP4) in gliomas is still unclear by now. We try to investigate the relationship between BMP4 expression and the biological behavior of gliomas in order to lay a foundation for the management of these tumors.A total of 630 patients with glioma were enrolled in the study from January 2002 to January
Wu, Qiang, Yao, Jiarui
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High glucose promotes the progression of colorectal cancer by activating the BMP4 signaling and inhibited by glucagon-like peptide-1 receptor agonist

BMC Cancer, 2023
Background The detailed molecular mechanism between type 2 diabetes mellitus (T2DM) and colorectal cancer (CRC) is still uncertain. Bone morphogenetic protein 4 (BMP4) dysregulation is implicated in T2DM and CRC, respectively.
Bingwei Ma, Xingchun Wang, Hui Ren, Yingying Li, Haijiao Zhang, Muqing Yang, Jiyu Li   +6 more
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