Results 11 to 20 of about 32,745 (240)

BMP4 Activation and Secretion Are Negatively Regulated by an Intracellular Gremlin-BMP4 Interaction [PDF]

Journal of Biological Chemistry, 2006
Bone morphogenetic protein 4 (BMP4) is a potent growth factor that is involved in many important biological processes. Regulation of the level of secreted mature BMP4 determines the biological effects of BMP4 on cells in the local microenvironment. Previous studies suggested that Gremlin, a member of DAN family proteins, antagonizes BMP4 activity by ...
Sun, Jianping, Zhuang, Feng Feng, Mullersman, Jerald E., Chen, Hui, Robertson, Elizabeth J., Warburton, David, Liu, Yi Hsin, Shi, Wei   +7 more
openaire   +5 more sources

BMP4 aggravates mitochondrial dysfunction of HRMECs

Heliyon, 2023
Mitochondria are important places for the oxidative phosphorylation of glucose and the maintenance of cell oxidation and antioxidant stability. However, mitochondrial dysfunction causes cell dysfunction. Meanwhile, retinal vascular endothelial cell dysfunction may cause vascular inflammation, hemorrhage, angiogenesis, and other manifestations.
Yong Wang, Hui Li, Jingjing Cao, Aihua Liu, Zhenyu Kou, Weiting An, Jingli Liang, Xiaomin Zhang, Xiaorong Li, Lijie Dong   +9 more
openaire   +4 more sources

BMP4 promotes hepatocellular carcinoma proliferation by autophagy activation through JNK1-mediated Bcl-2 phosphorylation

Journal of Experimental & Clinical Cancer Research, 2018
Background Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, plays a crucial role in human ...
Ganlu Deng, Shan Zeng, Yanling Qu, Qingqing Luo, Cao Guo, Ling Yin, Ying Han, Yiyi Li, Changjing Cai, Yaojie Fu, Hong Shen   +10 more
doaj   +2 more sources

Characteristics of quiescent adult neural stem cells induced by the bFGF/BMP4 combination or BMP4 alone in vitro

Frontiers in Cellular Neuroscience
Bone morphogenetic protein-4 (BMP4) is involved in regulation of neural stem cells (NSCs) proliferation, differentiation, migration and survival. It was previously thought that the treatment of NSCs with BMP4 alone induces astrocytes, whereas the ...
Sutong Xu, Xi Zhang, Zhuoqun Li, Chenming Liu, Qiulu Liu, Huazhen Chai, Hongkai Yao, Yuping Luo, Yuping Luo, Siguang Li, Siguang Li, Chun Li, Chun Li   +12 more
doaj   +3 more sources

BMP4 (bone morphogenetic protein 4) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013
Review on BMP4 (bone morphogenetic protein 4), with data on DNA, on the protein encoded, and where the gene is implicated.
Thériault, BL, Nachtigal, MW
openaire   +4 more sources

Loss of tumor-derived SMAD4 enhances primary tumor growth but not metastasis following BMP4 signalling

Cell Communication and Signaling
Background Bone morphogenetic protein 4 (BMP4) is a potent inhibitor of breast cancer metastasis. However, a tumor-promoting effect of BMP4 is reported in other tumor types, especially when SMAD4 is inactive.
Lap Hing Chi, Andrew D. Redfern, Suraya Roslan, Ian P. Street, Allan D. Burrows, Robin L. Anderson   +5 more
doaj   +2 more sources

SIX2 and BMP4 Mutations Associate With Anomalous Kidney Development [PDF]

Journal of the American Society of Nephrology, 2008
Renal hypodysplasia (RHD) is characterized by reduced kidney size and/or maldevelopment of the renal tissue following abnormal organogenesis. Mutations in renal developmental genes have been identified in a subset of affected individuals. Here, we report the first mutations in BMP4 and SIX2 identified in patients with RHD.
BAKKALOĞLU, AYŞİN, Burdine, Rebecca D., Schaefer, Franz, Network, Escape, Antignac, Corinne, Mehls, Otto, Ghiggeri, Gian Marco, Emre, Sevinc, Litwin, Mieczyslaw, Caldas-Alfonso, Alberto, Zurowska, Aleksandra M., Knueppel, Tanja, Schild, Raphael, Sullivan-Brown, Jessica, Baker, Kari F., Winyard, Paul, Taylor, Jaclyn C., Weber, Stefanie   +17 more
openaire   +4 more sources

One‐Step Induction of Oogonia‐Like and Pro‐Spermatogonia‐Like Cells From Porcine Pluripotent Stem Cells [PDF]

Advanced science
This study established a one‐step method inducing pro‐spermatogonia‐like (activating SOX17) and oogonia‐like (activating SOX17/TFAP2C) cells from porcine pgEpiSCs with a NANOS3‐tdTomato reporter. EGF activates the core PGC program and supports survival; BMP4 further induces NANOS3 and DDX4 expression; IWR1 enhances PGCLC efficiency by suppressing ...
He P, Zhong L, Chen T, Yan Y, Chen X, Li R, Wang Y, Teng Y, Zhi M, Wang M, Zhang J, Zhao F, Gao D, Cao S, Han J.   +14 more
europepmc   +2 more sources

Bone morphogenetic protein 4 alleviates nonalcoholic steatohepatitis by inhibiting hepatic ferroptosis

Cell Death Discovery, 2022
Nonalcoholic steatohepatitis (NASH) is a state of simple steatosis that progresses to inflammation and liver injury accompanied by ferroptosis. Bone morphogenetic protein 4 (BMP4) plays an important role in adipogenesis and differentiation, as well as in
Xingchun Wang, Bingwei Ma, Xin Wen, Hui You, Chunjun Sheng, Le Bu, Shen Qu   +6 more
doaj   +1 more source

A Wnt-BMP4 Signaling Axis Induces MSX and NOTCH Proteins and Promotes Growth Suppression and Differentiation in Neuroblastoma

Cells, 2020
The Wnt and bone morphogenetic protein (BMP) signaling pathways are known to be crucial in the development of neural crest lineages, including the sympathetic nervous system.
Marianna Szemes, Zsombor Melegh, Jacob Bellamy, Alexander Greenhough, Madhu Kollareddy, Daniel Catchpoole, Karim Malik   +6 more
doaj   +1 more source