Results 21 to 30 of about 88,042,096 (284)

Limitations of bone formation in oral implantology: inhibition of osteoblast functions by gingival tissues [PDF]

, 2010
PhDClinical observation suggest that bone formation is influenced by the environmental niche where it takes place and specifically that soft connective tissues may inhibit the bone healing process.
Al-Masri, Maher
core   +4 more sources

Interaction between Soluble Type I Receptor for Bone Morphogenetic Protein and Bone Morphogenetic Protein-4 [PDF]

Journal of Biological Chemistry, 1997
Bone morphogenetic proteins (BMPs) are multifunctional proteins that comprise the largest subfamily of the transforming growth factor-beta. These proteins bind to types I and II serine/threonine kinase receptors. Ligand-induced heteromeric dimerization of these receptors is the key event in initiation of biological responses. We report here large-scale
T, Natsume, S, Tomita, S, Iemura, N, Kinto, A, Yamaguchi, N, Ueno   +5 more
openaire   +2 more sources

Bone Morphogenetic Protein-4, a Novel Modulator of Melanogenesis [PDF]

Journal of Biological Chemistry, 2006
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta family, signal in many cells including neural precursors. Two receptors, types 1 and 2, coordinately mediate BMP signaling, and type 1 receptor has two forms: A and B. Using RT-PCR we found that neural crest-derived human melanocytes express BMP receptor-1A, -1B, and -2.
Mina, Yaar, Christina, Wu, Hee-Young, Park, Izabela, Panova, Gunther, Schutz, Barbara A, Gilchrest   +5 more
openaire   +2 more sources

Ectopic transient overexpression of facilitates BMP4-induced osteogenic transdifferentiation of human umbilical vein endothelial cells

Journal of Tissue Engineering, 2020
Limitation in cell sources for autologous cell therapy has been a recent focus in stem cell therapy and tissue engineering. Among various research advances, direct conversion, or transdifferentiation, is a notable and feasible strategy for the generation
Seung Hyun L Kim, Seunghun S Lee, Inseon Kim, Janet Kwon, Song Kwon, Taegeun Bae, Junho Hur, Hwajin Lee, Nathaniel S Hwang   +8 more
doaj   +1 more source

A Role for Bone Morphogenetic Protein-4 in Adipocyte Development [PDF]

Cell Cycle, 2007
Obesity is characterized by increases in the number of mature adipocytes. Nascent adipocytes arise from mesenchymal stem cells (MSCs) by a multi-step process--MSCs are recruited to the adipocyte lineage forming determined preadipocytes, these committed progenitors proliferate, undergo growth arrest, and finally differentiate into mature adipocytes ...
Robert R, Bowers, M Daniel, Lane
openaire   +2 more sources

Bone Morphogenetic Protein 1 Prodomain Specifically Binds and Regulates Signaling by Bone Morphogenetic Proteins 2 and 4 [PDF]

Journal of Biological Chemistry, 2007
Highly purified fractions of bone extracts capable of inducing ectopic bone formation have been reported to contain peptides corresponding to the mature active regions of the TGF-beta-like bone morphogenetic proteins (BMPs) 2-7, and to the prodomain region of the metalloproteinase BMP1.
Reema, Jasuja, Gaoxiang, Ge, Nikolas G, Voss, Jamie, Lyman-Gingerich, Amanda M, Branam, Francisco J, Pelegri, Daniel S, Greenspan   +6 more
openaire   +2 more sources

USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling [PDF]

, 2014
Protein kinase ALK3/BMPR1A mediates bone morphogenetic protein (BMP) signalling through phosphorylation and activation of SMADs 1/5/8. SMAD6, a transcriptional target of BMP, negatively regulates the BMP pathway by recruiting E3 ubiquitin ligases and ...
Bruce, David, Smith, James C., Dingwell, Kevin S., Cummins, Timothy D., Ewan, Richard, Macartney, Thomas, Al-Salihi, Mazin A., Weidlich, Simone, Vogt, Janis, Herhaus, Lina, Sapkota, Gopal P., Wasmus, Lise   +11 more
core   +1 more source

Addition of bone morphogenetic protein type 2 to ascorbate and β-glycerophosphate supplementation did not enhance osteogenic differentiation of human adipose-derived stem cells

Journal of Applied Oral Science, 2012
Bone morphogenetic protein type 2 (BMP-2) is a potent local factor, which promotes bone formation and has been used as an osteogenic supplement for mesenchymal stem cells.
Ariadne Cristiane Cabral Cruz, Mariana Lúcia Silva, Thiago Caon, Cláudia Maria Oliveira Simões   +3 more
doaj   +1 more source

Regulation of Phosphatase Homologue of Tensin Protein Expression by Bone Morphogenetic Proteins in Prostate Epithelial Cells [PDF]

, 2010
Phosphatase homologue of tensin (PTEN) is the key endogenous inhibitor of phosphoinositide signaling and is the most commonly mutated gene in human prostate cancer.
Travis Jerde, Wade Bushman, Travis J. Jerde, Zhong Wu, Dan Theodorescu   +4 more
core   +1 more source

Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling [PDF]

, 2014
Bone morphogenetic proteins (BMPs) control multiple cellular processes in embryos and adult tissues. BMPs signal through the activation of type I BMP receptor kinases, which then phosphorylate SMADs 1/5/8.
Smith, James C., Lina Herhaus, Janis Vogt, Gopal P. Sapkota, Gourlay, Robert, Macartney, Thomas, Campbell, David, Vogt, Janis, Herhaus, Lina, Sapkota, Gopal P., David Campbell, James C. Smith, Dingwell, Kevin S., Thomas Macartney, Kevin S. Dingwell, Robert Gourlay   +15 more
core   +1 more source